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CAS号712-97-0 6-硝基胡椒醛 | CAS号495-76-1 胡椒醇 | CAS号712-97-0 6-硝基胡椒醛 | CAS号15862-98-3 5-(chloromethyl... | CAS号5462-93-1 (6-nitrobenzo[1...

📜胡椒醇置于硝酸,溶剂黄146体系中,用63.3 %的收率获得6-硝基-3,4-亚甲基二氧苄乙醇
参考文献:反式玉米素的光响应和四嗪响应调制
标题:反式玉米素的光响应和四嗪响应调制
摘要:适当设计的笼养激素的光辐射和小有机分子触发能够以高空间和时间分辨率控制和操纵相应的生物过程.已经合成了被硝基苯碳酸酯取代作为光可去除保护基团的笼状反式玉米素和作为四嗪响应基序的反式环辛烯.已实现捕获的反式玉米素分子的平稳释放,允许有针对性地干扰生物过程,包括降解,糖基化和适当酶的识别.
Doi:10.1021/acs.Joc.2C02601

专利信息

专利号:US-10378051-B2
优先权日:2011-09-29
标题:Continuous extension and deblocking in reactions for nucleic acids synthesis and sequencing
发明人：MEULEMAN WOUTER; CRESSINA ELENA; SMITH GEOFFREY PAUL; JACKSON ROSAMOND; LIU XIAOHAI
权利人:ILLUMINA CAMBRIDGE LTD
摘要:A reaction mixture including (a) a nucleic acid having a primer hybridized to a template, (b) nucleotide analogs, wherein the nucleotide analogs have a blocking moiety; (c) a polymerase that is capable of forming an extended primer by adding the nucleotide analogs to the primer, and (d) a deblocking agent that is capable of removing the blocking moiety from the extended primer. Also provided is a method of synthesizing a polynucleotide including sequentially adding a plurality of the different nucleotides analogs to the nucleic acid via several reaction cycles in the reaction mixture, wherein each reaction cycle includes (i) the polymerase adding a nucleotide analog to the nucleic acid to form a transient nucleic acid species comprising a blocking moiety, and (ii) the deblocking agent modifying the transient nucleic acid species to remove the blocking moiety.