CAS: 1404-55-3; Ristocetin
该化合物是一种甘蓝丙烯酸抗生素,原产于Amycoltopsis 月球,主要用于临床和研究环境,以培养其吸收小板聚集的能力,使其成为诊断Von Willebrand疾病和Bernard-Soulier综合症的宝贵工具.Ristoceptin与von Willebrand因子(vWF)结合,促进其与小板胶蛋白 Ib (GPIb) 受体的相互作用.这一机制对于评估凝固研究中的VWF的功能至关重要.它的特性和可靠性在基因测量分析中强调了其在血压诊断中的重要性.Ristoctin还被用于微生物研究抗生素细菌中的抗生素抗机制.严格的质量控制确保成批到批到批量的一致性,以便产生可复制的结果.
- 英文名称Ristocetin
- 中文名称瑞斯西丁素
- IUPAC名称A name could not be generated for this structure.
- 其它别名RIST°CETIN A; RIST°CETIN SULFATE; RIST°CETIN A SULFATE; RISTON; RISTOMYCIN MONOSULPHATE; RISTOMYCIN MONOSULFATE SULFATE SALT; RISTOMYCIN MONOSULFATE; RISTOMYCIN
- CAS编号1404-55-3
- MFCD编号:MFCD00076121
- EINECS号:215-770-5
- 分子式:C95H112N8O48S分子量:2166.0
- 产品CID: 624828
- 产品分类原料药 → 抗生素类药物
物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2902600000-乙苯
2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Stufano F, Lawrie AS, La Marca S, Berbenni C, Baronciani L, Peyvandi F. A two-centre comparative evaluation of new automated assays for von Willebrand factor ristocetin cofactor activity and antigen. Haemophilia. 2014 Jan;20(1):147-53. doi: 10.1111/hae.12264. Epub 2013 Sep 12. doi: 10.1002/chir.22291. Epub 2014 Jan 22. doi: 10.1111/hae.12203. Epub 2013 Jun 4.
5: Sagheer S, Rodgers S, Yacoub O, Dauer R, Mcrae S, Duncan E. Comparison of von Willebrand factor (VWF) activity levels determined by HemosIL AcuStar assay and HemosIL LIA assay with ristocetin cofactor assay by aggregometry. Haemophilia. 2016 May;22(3):e200-7. doi: 10.1111/hae.12937. Epub 2016 Apr 14. doi: 10.1111/j.1600-0609.2012.01760.x. Epub 2012 Feb 15. doi: 10.1107/S0907444909018344. Epub 2009 Jul 17. Erratum in: Acta Crystallogr D Biol Crystallogr. 2011 Jun;67(Pt 6):592.
10: Hayward CP, Moffat KA, Graf L. Technological advances in diagnostic testing for von Willebrand disease: new approaches and challenges. Int J Lab Hematol. 2014 Jun;36(3):334-40. doi: 10.1111/ijlh.12220. Review. doi: 10.1111/j.1538-7836.2009.03594.x. Epub 2009 Aug 19.
合成参考文献
参考文献:10.1055/s-2005-872896
摘要:Klemm T, Mehnert AK, Siegemund A, Wiesner TD, Gelbrich G, Blüher M, Paschke R. Impact of the Thr789Ala variant of the von Willebrand factor levels, on ristocetin co-factor and collagen binding capacity and its association with coronary heart disease in patients with diabetes mellitus type 2. Exp Clin Endocrinol Diabetes. 2005 Dec;113(10):568–72. doi: 10.1055/s-2005-872896.
参考文献:10.1179/102453311x12953015767617
摘要:Djunic I, Elezovic I, Ilic V, Tomin D, Suvajdzic-Vukovic N, Bila J, Antic D, Vidovic A, Milosevic-Jovcic N. Acquired von Willebrand syndrome in multiple myeloma. Hematology. 2011 Jul;16(4):209–12. doi: 10.1179/102453311x12953015767617.
参考文献:10.1097/mbc.0b013e32834a04d3
摘要:D'Souza PM, Blostein MD. Diagnosis of Heyde's syndrome by abnormal closure times despite normal von Willebrand's activity. Blood Coagul Fibrinolysis. 2011 Oct;22(7):622–3. doi: 10.1097/mbc.0b013e32834a04d3.
📝 需求与反馈
尽可能描述清楚需求与问题信息
