CAS: 13698-49-2; [(8R,9S,10R,13S,14S,17R)-17-Acetyl-6-Chloro-10,13-Dimethyl-3-Oxo-9,11,12,14,15,16-Hexahydro-8H-Cyclopenta[a]Phenanthren-17-Yl] Acetate

上下游产品

醋酸氯地孕酮 Chlormadinone Acetate 302-22-7
地马孕酮 Delmadinone 15262-77-8
1,6-Didehydro-17α-Hydroxyprogesterone 66212-25-7
17Alpha-羟基黄体酮 17-Hydroxyprogesterone 68-96-2
雄甾-1,4,6-三烯-3,17-二酮 1,4,6-Androstatriene-3,17-Dione 633-35-2

醋酸氯地孕酮置于2,3-二氯-5,6-二氰基-1,4-苯醌体系中,用 1,4-二氧六环 用作溶剂,化学反应 3.0H,以87.6%的收率获得醋酸地马孕酮
参考文献:Antiandrogen. I. 2-Azapregnane And 2-Oxapregnane Steroids.
标题:Antiandrogen. I. 2-Azapregnane And 2-Oxapregnane Steroids.
摘要:2-氮氯马地酮乙酸酯(5A,17-乙酰氧基-6-氯-2-氮孕-4,6-二烯-3,20-二酮),2-氧氯马地酮乙酸酯(6,17-乙酰氧基-6-氯-2-氧孕-4,6-二烯-3,20-二酮)及其衍生物被制备为潜在的抗雄激素剂.生物评估显示,在去势雄性大鼠中,5A和6表现出强大的抗雄激素活性.
Doi:10.1248/cpb.40.935

专利信息

专利号:US-2025289827-A1
优先权日:2022-12-02
标 题:Morphic forms of a mutant braf degrader and methods of manufacture thereof
发明人：YU ROBERT T; HE MINSHENG; SCHNADERBECK MATTHEW J; KREGER BRIDGET; POLLOCK ROY MACFARLANE; JIANG SIYI; LI MEIQI; CHEN BOLU; LU JIANNAN
权利人:C4 THERAPEUTICS INC
摘要:Advantageous isolated morphic forms of (3R)-3-[6-[2-cyano-3-[[ethyl(methyl)sulfamoyl]amino]-6-fluorophenoxy]-4-oxoquinazolin-3-yl]-8-[2-[1-[3-(2,4-dioxo-1,3-diazinan-1-yl)-5-fluoro-1-methylindazol-6-yl]-4-hydroxypiperidin-4-yl]acetyl]-1-oxa-8-azaspiro[4.5]decane (Compound 1), which is a mutant BRAF degrader, and methods to prepare Compound 1 morphic forms for therapeutic applications are provided in the invention. The invention also provides improved methods for the synthesis of Compound 1, new pharmaceutical compositions comprising Compound 1, and new uses of Compound 1.

专利号:US-2004024230-A1
优先权日:2002-04-29
标 题:Synthesis of cyproterone acetate

专利号:US-2006211873-A1
优先权日:2002-04-29
标 题 :Synthesis of cyproterone acetate
发明人：MANOSROI ARANYA; MANOSROI JIRADEJ; BUDDHASUKH DUANG; SRIPALAKIT PATTANA; MAIER ROLAND; WERNER ROLF G
权利人:BOEHRINGER INGELHEIM INT
摘要:The present invention relates to improved methods for synthesising cyproterone acetate (17α-Acetoxy-6-chloro-1α, 2(α-methylene-4,6-pregnadiene-3,20-dione) from solasodine.

专利号:NZ-536590-A
优先权日:2002-04-29
标 题:Improved synthesis of cyproterone acetate

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.