CAS: 113-73-5; Gramicidin S

上下游产品

[orn(Boc)2,2']Gramicidin 41839-95-6
D-Phe-Pro-Val-Orn-Leu-D-Phe-Pro-Val-Orn-Leu 83830-88-0
H-D-Phe-Pro-Val-Orn(Boc)(Boc)-Leu-D-Phe-Pro-Val-Orn(Boc)(Boc)-Leu-Oh 1054661-52-7
D-Phe-L-Pro 51926-52-4

📜H-D-Phe-Pro-Val-Orn(Boc)(Boc)-Leu-D-Phe-Pro-Val-Orn(Boc)(Boc)-Leu-Oh置于benzotriazol-1-Yloxyl-Tris-(Pyrrolidino)-Phosphonium Hexafluorophosphate,1-羟基苯并三唑,N,N-二异丙基乙胺,三氟乙酸体系中,用 二氯甲烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 18.5H,反应生成短杆菌肽 S
参考文献:实用的土霉素s和含糖氨基酸类似物的合成
标题:实用的土霉素s和含糖氨基酸类似物的合成
摘要:提出了一种实用的克级和高收率的抗菌肽短杆菌肽s的合成方法.使用基于fmoc的固相肽合成方案来生成线性十肽前体,将其在溶液中环化以提供目标化合物.我们的方法的通用性是由八个短杆菌肽小号类似物(施工证明15A-ħ具有nonproteinogenic糖的氨基酸残基()4-7)在返回区域并入.
Doi:10.1021/jo0487449

专利信息

专利号:US-11186835-B2
优先权日:2018-01-11
标题 :Artificial ribosomes for fully programmable synthesis of nonribosomal peptides
发明人：GREEN ALEXANDER A
权利人:UNIV ARIZONA STATE
摘要:Provided herein, in some embodiments, are artificial ribosomes that synthesize nonribosomal peptides, polyketides, and fatty acids with full control over peptide sequence. Also provided herein are methods for programmed synthesis of nonribosomal peptides, polyketides, and fatty acids. In particular, provided herein are methods for scalable synthesis of a wide range of antibacterial, antifungal, antiviral, and anticancer compounds.

专利号:EP-2021360-B1
优先权日:2006-04-26
标 题:CYCLODIPEPTIDE SYNTHETASE AND ITS USE FOR SYNTHESIS OF CYCLO(TYR-Xaa) CYCLODIPEPTIDES
发明人：BELIN PASCAL; GONDRY MURIEL; THAI ROBERT; PERNODET JEAN-LUC; GENET ROGER
权利人:COMMISSARIAT ENERGIE ATOMIQUE; KYOWA HAKKO BIO CO LTD; UNIV PARIS SUD 11; CENTRE NAT RECH SCIENT
摘要:Isolated, natural or synthetic polynucleotide and polypeptide encoded by said polynucleotide, that is involved in the synthesis of cyclodipeptides, recombinant vector comprising said polynucleotide or any substantially homologous polynucleotide, host cell modified with said polynucleotide or said recombinant vector and also methods for in vitro and in vivo synthesizing cyclodipeptides, in particular cyclo(Tyr-Xaa) cyclodipeptides, wherein Xaa is any amino acid and their derivatives and applications thereof.

专利号:EP-2021357-B1
优先权日:2006-04-26
标 题:Cyclodipeptide synthetases and their use for synthesis of cyclo(leu-leu) cyclodipeptide
发明人：GONDRY MURIEL; THAI ROBERT; BELIN PASCAL; GENET ROGER; PERNODET JEAN-LUC
权利人:COMMISSARIAT ENERGIE ATOMIQUE; KYOWA HAKKO BIO CO LTD; UNIV PARIS SUD; CENTRE NAT RECH SCIENT
摘要:Isolated, natural or synthetic polynucleotides and the polypeptides encoded by said polynucleotides, that are involved in the synthesis of cyclodipeptides, the recombinant vectors comprising said polynucleotides or any substantially homologous polynucleotides, the host cell modified with said polynucleotides or said recombinant vectors and also methods for in vitro and in vivo synthesizing cyclo(Leu-Leu) cyclodipeptide and its derivatives and applications thereof.

专利号:WO-2024199465-A1
优先权日:2023-03-30
标 题:Unnatural amino acid in cellulo synthesis for site-specific protein modification
发明人：CHAN MICHAEL KENNETH; LEE MARIANNE; CHENG JIAHUI
权利人:UNIV HONG KONG CHINESE
摘要:Provided are genetically modified host cells containing engineered enzymes that support the synthesis of unnatural amino acids, such as D-Cys-ε-Lys, and the incorporation of such unnatural amino acids into a newly synthesized protein. These cells are therefore capable of in vivo or in cellulo synthesis of a protein containing one or more unnatural amino acids strategically placed at pre-determined locations for site-specific modification of the protein. Also provided are the corresponding methods for in vivo synthesis of modified proteins as well as the modified proteins produced by the method.

专利号:US-9453044-B2
优先权日:2012-02-07
标题 :Method of synthesizing peptides, proteins and bioconjugates
发明人：LIU CHUAN FA; ZHAO JUNFENG
权利人:UNIV NANYANG TECH
摘要:The invention relates to the synthesis of peptides, proteins and related bioconjugates, and in particular, to such synthesis using a peptide ligation method whereby a C-terminal salicylaldehyde ester peptide is reacted with an aminoacyl-N-hydroxl peptide. The invention also relates to the synthesis of cyclic peptides, including serinyl- or threonyl-containing cyclic peptides. The invention further relates to a solid phase synthesis of C-terminal salicylaldehyde ester peptides.

专利号:US-7951905-B2
优先权日:2006-09-18
标 题 :Synthesis of carbohydrate-templated amino acids and methods of using same
发明人：SCHWEIZER FRANK; ZHANG KAIDONG; OWENS NEIL; ZHANEL GEORGE
权利人:UNIV MANITOBA
摘要:The present invention generally relates to tetrahydropyranyl-derivatized amino acids, their syntheses and their incorporation into peptides and peptidomimetics. The tetrahydropyran moiety constrains the side chain of an amino acid, thereby providing a molecule that may act as a sugar- or amino acid-mimetic as well as a scaffold for combinatorial synthesis.