CAS: 109921-55-3; N-[2-(5-Methoxy-1H-Indol-3-yl)Ethyl]Propan-2-Amine

上下游产品

2-(5-methoxyindol-3-yl)ethylamine acetone 14H18N2°C14H18N2O 5-Methoxy-N,N-diisopropyltryptamine

📜N-[2-(5-Methoxy-1H-Indol-3-yl)Ethyl]Propan-2-Imine置于sodium Tetrahydroborate体系中,用 甲醇 用作溶剂,化学反应生成N-异丙基-5-甲氧基色氨酸
参考文献:Novel Tetrahydro-β-Carboline-1-Carboxylic Acids As Inhibitors Of Mitogen Activated Protein Kinase-Activated Protein Kinase 2 (Mk-2)
标题:Novel Tetrahydro-β-Carboline-1-Carboxylic Acids As Inhibitors Of Mitogen Activated Protein Kinase-Activated Protein Kinase 2 (Mk-2)
摘要:A Structure-Activity Relationship Study Was Conducted On A Series Of Tetrahydro-Beta-Carboline-1-Carboxylic Acid Analogs In Order To Identify The Key Functionality Responsible For Activity Against The Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Enzyme (Mk-2). The Compounds Were Further Evaluated For Their Ability To Inhibit Tnf Alpha Production In U937 Cells And In Vivo. These Compounds Represent A Novel Structural Class Of Compounds Capable Of Inhibiting Mk-2 With Remarkable Selectivity. (C) 2007 Elsevier Ltd. All Rialuts Reserved.
Doi:10.1016/j.Bmcl.2007.05.070

专利信息

专利号:US-7186709-B2
优先权日:2002-08-27
标 题:Dihydropyrancarboxamides and uses thereof
发明人：SCHREIBER STUART L; STAVENGER ROBERT A; MITCHISON TIMOTHY J; MALIGA ZOLTAN
权利人:HARVARD COLLEGE
摘要:The present invention provides novel dihydropyrancarboxamide compounds of formula (I): n nand collections of these compounds, and provides methods for the synthesis of these compounds; wherein R 1 –R 6 are as defined herein. Additionally, the present invention provides pharmaceutical compositions and methods for treating disorders such as proliferative diseases, and cancer, to name a few.