CAS: 77421-13-7; (2-Chlorophenyl)Methanesulfonyl Chloride

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CAS号3778-85-6 {氨基[(2-氯苄基)硫代]亚... | CAS号41345-36-2 Sodium 2-chloro... | CAS号611-19-8 邻氯氯苄 | CAS号24827-66-5 1-methyl-1,3-di... | CAS号5162-03-8 2-氯二苯甲酮 | CAS号2136-89-2 2-氯苯并三氯 | CAS号111248-89-6 1,3-二氢-2,1-苯并异噻... | CAS号89665-79-2 (2-氯苯基)甲磺酰胺

📜2-氯苄溴置于sodium Sulfite,三氯氧磷体系中,用 水,丙酮,乙腈 作为反应溶剂,化学反应 4.0H,反应生成 (2-氯苯基)甲基磺酰氯
参考文献:O-(芳磺酰基)羟胺的氨基重排:轻松获得邻磺酰基苯胺
标题:O-(芳磺酰基)羟胺的氨基重排:轻松获得邻磺酰基苯胺
摘要:据报道,羟胺衍生物的芳族重排可从简单的起始原料直接反应生成邻磺酰基苯胺.这是通过形成新的 Cn 键来实现的,该键对邻位异构体具有出色的区域控制水平,这被认为是在 Cn 键形成步骤中发生有吸引力的非共价相互作用的结果.
DOI:10.1002/anie.202204025

专利信息

专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.