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📜4-(3-Chloropropoxy)Benzoic Acid Methyl Ester置于甲醇,Potassium Carbonate,Potassium Iodide,Sodium Hydroxide体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 6.5H,反应生成 4-(3-(哌啶-1-基)丙氧基)苯甲酸
参考文献:Novel And Highly Potent Histamine H3 Receptor Ligands. Part 1: Withdrawing Of Herg Activity
标题:Novel And Highly Potent Histamine H3 Receptor Ligands. Part 1: Withdrawing Of Herg Activity
摘要:Pre-Clinical Investigation Of Some Aryl-Piperidinyl Ether Histamine H3 Receptor Antagonists Revealed A Strong Herg Binding. To Overcome This Issue,We Have Developed A Qsar Model Specially Dedicated To H3 Receptor Ligands. This Model Was Designed To Be Directly Applicable In Medicinal Chemistry With No Need Of Molecular Modeling. The Resulting Recursive Partitioning Trees Are Robust (80-85% Accuracy),But Also Simple And Comprehensible. A Novel Promising Lead Emerged From Our Work And The Structure-Activity Relationships Are Presented. (C) 2011 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2011.07.006