CAS: 708-74-7; 6-Methylpteridine-2,4-Diamine

上下游产品

2,4,5,6-tetraaminopyrimidine N-acetyl-α-aminopropionaldehyde 1-(benzenesulfonyl)-4-methylimidazolin-2-one 1-(4-Fluoro-benzenesulfonyl)-4-methyl-1,3-dihydro-imidazol-2-one 2-amino-6-methylpteridin-4(1H)-one methotrexate di-t-butyl ester 2,4-diamino-6-dibromomethylpteridine 6-bromomethyl-pteridine-2,4-diamine

📜6-Methyl-2-Pivaloylamino-4-<1'-(1,2,4-Triazolyl)>Pteridine置于ammonium Hydroxide体系中,用 1,4-二氧六环 作为反应溶剂,化学反应 96.5H,反应生成 6-甲基-2,4-蝶啶二胺
参考文献:Taylor,Edward C.; Otiv,S. R.; Durucasu,Inci,Heterocycles,1993,Vol. 36,# 8,P. 1883-1895
标题:Taylor,Edward C.; Otiv,S. R.; Durucasu,Inci,Heterocycles,1993,Vol. 36,# 8,P. 1883-1895

专利信息

专利号:US-4306064-A
优先权日:1980-03-25
标 题:Synthesis of 2,4-diamino-6-hydroxymethylpteridine
发明人：ELLARD JAMES A; SATANEK JR JOSEPH
权利人:ELLARD JAMES A; SATANEK JR JOSEPH
摘要:In a method of preparing methotrexate from a coupling of 2,4-bis(triphenylphosphazino)-6-bromomethylpteridine hydrobromide with ethyl N-(p-methylamino)-benzoyl-L-glutamate to produce the phosphazino derivative of methotrexate ester and subsequently hydrolyzing the phosphazino and ester groups to produce the free methotrexate, the pteridine synthesis step wherein molecular oxygen is substituted for reaction air and the pH throughout the pteridine synthesis is regulated to between 2.5 and 5.4, the preferred pH being about 3.0 and producing from tetraaminopyrimidine and dihydroxyacetone the isomer 2,4-diamino-6-hydroxymethylpteridine over 2,4-diamino-7-hydroxymethylpteridine in a ratio of about 20:1. Exemplary of other situations involving pteridine where the molecular oxygen may be substituted for reaction air are: in the production of folic acid, tetrahydrofolic acid, etc.