CAS: 705254-34-8; Potassium Trifluoro(4-(Methoxycarbonyl)Phenyl)Borate

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CAS号1126-46-1 甲基-4-氯苯甲酸甲酯 | CAS号1279123-63-5 potassium hydro... | CAS号13675-18-8 四羟基二硼烷 | CAS号619-42-1 对溴苯甲酸甲酯 | CAS号99768-12-4 4-甲酯基苯硼酸 | CAS号93-58-3 苯甲酸甲酯 | CAS号1126-46-1 甲基-4-氯苯甲酸甲酯 | CAS号35112-28-8 2,4-二氯苯甲酸甲酯 | CAS号99768-12-4 4-甲酯基苯硼酸 | CAS号403-33-8 对氟苯甲酸甲酯 | CAS号99-76-3 尼泊金甲酯 | CAS号2967-66-0 4-(三氟甲基)苯甲酸甲酯 | CAS号787-70-2 4,4'-联苯二甲酸 | CAS号619-42-1 对溴苯甲酸甲酯

📜对氯苯甲酸甲酯置于四羟基二硼,1,3-Bis[(Diphenylphosphino)Propane]Dichloronickel(II),N,N-二异丙基乙胺,三苯基膦,Potassium Hydrogen Difluoride体系中,用 乙醇,甲醇,水 作为反应溶剂,化学反应 12.5H,以89%的收率获得产物(4-甲氧羰基苯基)三氟硼酸钾
参考文献:镍催化四羟基二硼 [b2(Oh)4] 卤化物和拟卤化物的硼化反应
标题:镍催化四羟基二硼 [b2(Oh)4] 卤化物和拟卤化物的硼化反应
摘要:芳基硼酸作为试剂和目标结构在各种有用的应用中变得越来越重要.最近,报道了使用原子经济的四羟基二硼(bba)试剂在钯催化下合成芳基硼酸.钯的高成本,加上钯和铜催化工艺的一些限制,促使我们开发一种替代方法.因此,已经制定了使用四羟基二硼(bba)对芳基和杂芳基卤化物和拟卤化物进行镍催化的硼基化反应.该反应被证明具有广泛的官能团耐受性并适用于许多杂环体系.据我们所知,这里提供的例子代表了在室温下进行的唯一有效的镍催化宫浦硼化反应.
DOI:10.1021/jo401104Y

专利信息

专利号:US-8530689-B2
优先权日:2008-05-05
标 题 :Processes for the preparation of biphenyl compounds
发明人：PERCEC VIRGIL; ROSEN BRAD MATTHEW; WILSON DANIELA A; WILSON CHRISTOPHER J
权利人:PERCEC VIRGIL; ROSEN BRAD MATTHEW; WILSON DANIELA A; WILSON CHRISTOPHER J; UNIV PENNSYLVANIA
摘要:The invention concerns processes for the synthesis of a compound of the formula: wherein: R 1 and R 2 are each, independently, C 1 -C 12 alkyl, CO 2 R 3 , OR 4 , R 5 (OR 6 ), or C 6 -C 18 aryl; R 3 -R 6 are each, independently, C 1 -C 12 alkyl or C 6 -C 12 aryl; and n and m are each, independently, O or an integer from 1-5; said process comprising:—contacting a compound of the formula H0-R 7 -0H with BH 3 and a compound of the formula in the presence of a nickel-containing catalyst to produce a first product, where R 7 is a C 2 -C 12 hydrocarbon group and X is a halogen, OMs or OTs;—contacting the first product in situ with a compound of the formula: in the presence of a nickel-containing catalyst to produce a compound of formula I, where Z is a halogen.