CAS: 69320-90-7; (2S,3R)-Tert-Butyl 2-Amino-3-Hydroxybutanoate Hydrochloride
该化合物是氨酸L-threonine的一种受保护的衍生物,通常用于peptide合成.Tet-butyl ester组在有机溶剂中增加溶解性,并在混合反应中为碳苯基细胞提供...
- 英文名称(2S,3R)-Tert-Butyl 2-Amino-3-Hydroxybutanoate Hydrochloride
- 中文名称(2S,3R)-2-氨基-3-羟基丁酸叔丁酯盐酸盐
- IUPAC名称tert-butyl L-threoninate hydrochloride
- 其它别名L-苏氨酸叔丁酯盐酸盐; L-Threonine Tert.Butyl Ester Hydrochloride
- CAS编号69320-90-7
- MFCD编号:MFCD00672361
- EINECS号:856-749-6
- 分子式:C8H18ClNO3分子量:211.69
- 产品CID: 1688626
- 产品分类有机原料→分子砌块→手性化合物→手性砌块
相似化合物
24830-94-2 28954-12-3 39994-75-7物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
tert-butyl (2S,3R)-2-(benzyloxycarbonyl)amino-3-hydroxybutanoate合成工艺路线路线简述
📜2-甲基-2-丙基n-[(苄氧基)羰基]-L-苏氨酸酯置于palladium On Activated Charcoal,氢气,盐酸体系中,用 甲醇,乙醚,水 作为反应溶剂,以3.4 G的收率获得产物2,5-呋喃二甲醛
参考文献:城山酰胺b的全合成
标题:城山酰胺b的全合成
摘要:描述了双环二肽天然产物城山酰胺b的第一全合成.一种成功的方法是采用核心七肽的固相肽合成,并结合树脂上的酯化作用,然后进行溶液相大内酰胺化,并进行后期的分子内evans-Chan-Lam偶联,以反应生成异麦芽碱单元的联芳基醚.
DOI:10.1021/acs.Orglett.0C01642
海关参考信息
- 2905122000-异丙醇
2905143000-叔丁醇
2905399001-1,3-丙二醇
2909110000-乙醚 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2010204449-A1
优先权日:2007-09-04
标 题 :Methods and intermediates for chemical synthesis of polypeptides and proteins
发明人：DONG ZHENG XIN; KIM SUN H
权利人:DONG ZHENG XIN; KIM SUN H
摘要:The present invention relates to methods and intermediates for chemical synthesis of polypeptides and proteins, and more particularly to methods and intermediates for chemically ligating a peptide fragment containing N-terminal β-methyl-cysteine (SEQ ID NO: 1) with another peptide fragment having C-terminal thioester to generate a β-amino-thioester intermediate that spontaneously rearranges to form an amide bond. The invention also relates to methods of synthesizing β-methyl-cysteine (SEQ ID NO: 1) and its protected forms. Furthermore, the invention relates to converting a β-methyl-thiazolidine residue to a β-methyl-cysteine (SEQ ID NO: 1) residue of polypeptides and proteins.
专利号:WO-2009032181-A2
优先权日:2007-09-04
标 题:Methods and intermediates for chemical synthesis of polypeptides and proteins
专利号:EP-2197895-A2
优先权日:2007-09-04
标题 :Methods and intermediates for chemical synthesis of polypeptides and proteins
专利号:JP-2010538063-A
优先权日:2007-09-04
标 题:Methods and intermediates for chemical synthesis of polypeptides and proteins
专利号:ES-2408932-T3
优先权日:2008-06-25
标 题:Synthesis and use of heterocyclic antibacterial agents
专利号:CA-2728210-A1
优先权日:2008-06-25
标 题:Synthesis and use of heterocyclic antibacterial agents
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
合成方法参考DOI号:10.1021/acs.orglett.0c01642
📝 需求与反馈
尽可能描述清楚需求与问题信息
