📜P-Aminophenylguanidine置于aurf-R96E/t100A/l202F体系中,化学反应生成 N-4-硝基苯基胍 参考文献:Structural And Biochemical Basis For The Firm Chemo-And Regioselectivity Of The Nitro-Forming N-Oxygenase Aurf 标题:Structural And Biochemical Basis For The Firm Chemo-And Regioselectivity Of The Nitro-Forming N-Oxygenase Aurf 摘要:基于硫链丝菌素黄素(streptomyces Thioluteus)中硝基形成单加氧酶aurf的晶体结构进行的定点诱变研究表明,Aurf变体能够选择性地将胍基和脒基取代的苯胺转化为相应的硝基化合物.我们的结果为位选择性n-氧化提供了新的生化依据. DOI:10.1039/c0Cc02811H
专利信息
专利号:US-2005032187-A1 优先权日:2003-08-01 标题:Novel peptide-forming enzyme, microbe producing the enzyme and method for producing peptide using them 发明人:YOKOZEKI KENZO; SUZUKI SONOKO; HARA SEIICHI; KATAYAMA SATOSHI 权利人:AJINOMOTO KK 摘要:The present invention relates to a novel enzyme that allows peptide to be produced easily, inexpensively and at high yield without going through a complex synthesis method. More particularly, the present invention provides a novel enzyme that catalyzes a peptide-producing reaction from a carboxy component and an amine component, a microbe that produces the enzyme, and a method for inexpensive production of peptides using this enzyme or microbe. The novel enzyme that efficiently produces peptide was discovered from a newly discovered microbe belonging to the genus Empedobacter , and a method was found that allows peptides to be produced inexpensively and easily.
专利号:US-2005032154-A1 优先权日:2002-07-26 标题 :Method for producing tripeptides and/or peptides longer than tripeptides 发明人:YOKOZEKI KENZO; SUZUKI SONOKO; HARA SEIICHI; ABE ISAO 权利人:AJINOMOTO KK 摘要:It is an object of the present invention to provide a method that allows the production of peptides that are equal to or longer than tripeptides easily, inexpensively and at high yield without going through a complex synthesis method. The inventors of the present invention have found a novel enzyme that efficiently produces a peptide from bacteria belonging to the genus Empedobacter or the genus Sphingobacterium . In the present invention, this enzyme is allowed to act on a carboxy component and an amine component to produce peptides that are equal to or longer than tripeptides.
专利号:US-7749742-B2 优先权日:2002-07-26 标 题:Method for producing tripeptides and/or peptides longer than tripeptides 发明人:YOKOZEKI KENZO; SUZUKI SONOKO; HARA SEIICHI; ABE ISAO 权利人:AJINOMOTO KK 摘要:A method is disclosed that allows the production of peptides having three or more amino acid residues easily, inexpensively and at high yield without going through a complex synthesis method. A novel enzyme that efficiently produces a peptide from bacteria belonging to the genus Empedobacter or the genus Sphingobacterium is provided. The enzyme acts on a carboxy component and an amine component to form peptides having three or more amino acid residues by acting on a carboxy component and an amine component.
摘要:Dornan, P. K.; Dong, V. M., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 1, 161. 摘要:H. Koike. Nippon Kagaku Zasshi 83, 917 (1962); CA 58, 13301e.