专利号:EP-0196224-B1 优先权日:1985-03-29 标题:Synthesis of inotropic imidazo[4,5-c]pyridine 摘要:The present invention provides a process for preparing 2-[2-methoxy-4-(methylthio)phenyl]-1(3)H-imidazo[4,5-c]pyridine comprising reacting 3,4-diaminopyridine with 2-methoxy-4-methylthiobenzoic acid in the presence of phosphorus oxychloride and pyridine.
专利号:WO-9006913-A1 优先权日:1988-12-14 标 题:Explosion-proof 1-dimethylamino-3-dimethylimino-2-arylprop-1-ene salts, process for their preparation, and their use 发明人:MUELLER INGRID; HEMMERLING WOLFGANG; WINGEN RAINER 权利人:HOECHST AG 摘要:The invention concerns the preparation of explosion-proof trimethine salts which are only slightly soluble in water and have the formula (I), in which: R is an aryl or a heteroaryl group, which may contain one or more substituents, and X is an anion-equivalent of a non-oxidizing acid group which is inert with respect to trimethine cation and forms trimethine salts which are only slightly soluble in water, by formylation of compounds of the formula (II): R-CH2?-COOH, in which: R has the same meaning as in formula (I), under the conditions of the Vilsmeier-Haack reaction, followed by aqueous hydrolysis of the formylation products to form water-soluble primary trimethine salts, and reaction of the water-soluble primary trimethine salts in the aqueous reaction mixture with acids of the formula (III): (H)n?X, in which: X has the same meaning as in formula (I) and n is a number from 1 to 3, or with water-soluble salts of such acids, in at least stoichometric proportions, and separation of the resulting trimethine salts of formula (I) which are only slightly soluble in water. Trimethine salts of formula (I) can be used as intermediates in the synthesis of heterocyclic compounds, particularly pyrimidines and pyridines.
专利号:US-4740599-A 优先权日:1986-10-03 标 题 :Synthesis of alkylsulfinyl substituted 2-phenylimidazo(4,5-c)pyridines 发明人:GOEDDE JANE A; GREENE JAMES M 权利人:LILLY CO ELI 摘要:The present invention provides a process for preparing alkylsulfinyl 2-phenylimidazo[4,5-c]pyridines comprising reacting an N-(3-amino-4-pyridinyl)alkylthiobenzamide with an oxidizing agent in a lower alkanoic acid solvent.
专利号:EP-0196224-A1 优先权日:1985-03-29 标 题 :Synthesis of inotropic imidazo[4,5-c]pyridine
专利号:CA-1295330-C 优先权日:1985-03-29 标题:Synthesis of inotropic imidazo(4,5-c) pyridine
专利号:EP-0266897-A1 优先权日:1986-10-03 标题 :Synthesis of alkylsulfinyl substituted 2-phenylimidazo [4,5-c] pyridines
[参考文献]: Bingcai Pan, Et Al. Sorption Enhancement Of Aromatic Sulfonates Onto An Aminated Hyper-Cross-Linked Polymer. Environ Sci Technol. 2005 May 1;39(9):3308-13. [参考文献]: Elodie Alinat, Et Al. Analysis Of Underivatized Cellodextrin Oligosaccharides By Capillary Electrophoresis With Direct Photochemically Induced Uv-Detection. Electrophoresis. 2015 Jul;36(14):1555-63. [参考文献]: Rong Jiang, Et Al. Rich Aggregate Morphologies Induced By Organic Salts In Aqueous Solutions Of A Cationic Gemini Surfactant With A Short Spacer. J Colloid Interface Sci. 2009 Dec 1;340(1):98-103.
合成参考文献
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