CAS: 50270-27-4; 2,4,6-Trichloropyrimidine-5-Carbaldehyde

相似化合物

3029-64-9 93416-51-4 87846-94-4

上下游产品

CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号67-52-7 巴比妥酸 | CAS号28509-24-2 tert.-butyl-met... | CAS号42754-96-1 4,6-二氯-1H-吡唑啉[3... | CAS号21254-22-8 4,6-二氯-1-异丙基-1H... | CAS号98141-42-5 4,6-二氯-1-甲基-1H-... | CAS号1184920-55-5 4,6-二氯-1-(四氢-吡喃... | CAS号77456-66-7 2,4,6-三氯嘧啶-5-羰酰氯 | CAS号864292-48-8 4,6-二氯-1-乙基-1H-... | CAS号93416-51-4 2,4,6-三氯嘧啶-5-甲酸

巴比妥酸置于三氯氧磷体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 4.25H,以60%的收率获得产物2,4,6-三氯-5-嘧啶甲醛
参考文献:在存在碱金属离子的情况下,带有氧乙烯型间隔基的胆固醇基嘧啶系统对凝胶化和液晶元形成的差异响应†
标题:在存在碱金属离子的情况下,带有氧乙烯型间隔基的胆固醇基嘧啶系统对凝胶化和液晶元形成的差异响应†
摘要:合成了一系列新的2,4,6-三氯-嘧啶-5-甲醛的亲脂性胆固醇基衍生物.为了了解它们对这些化合物自组装的影响,在氢键促进嘧啶核心和胆固醇尾基之间插入了可变长度的氧乙烯间隔基.只有具有最短间隔基的化合物1A在有机溶剂(例如正丁醇和正十二烷)中形成凝胶.而其他具有较长间隔基的成员(1B和c)则导致正丁醇和n中的溶胶形成和沉淀-十二烷.使用依赖于温度的uv-Vis和cd光谱研究了与胶凝过程相关的自组装现象.通过扫描电子显微镜(sem)和原子力显微镜(afm)检查了从不同有机溶剂获得的冻干凝胶的形态特征.使用偏振光学显微镜(pom)和差示扫描量热法(dsc)探索了这些分子及其相关的碱金属离子配合物的固相行为.使用广角x射线衍射(waxd)技术进一步探查了干凝胶和固态分子的排列方式.对广角x射线衍射数据的分析表明,这类分子在凝胶和固态时采用六边形柱状组织.这些六边形柱状结构的每个切片均由二聚体分子组
DOI:10.1039/c4Sm02792B

专利信息

专利号:US-4567260-A
优先权日:1982-07-01
标题:Synthesis of 5-deazariboflavine
发明人：YONEDA FUMIO
权利人:TOYO JOZO KK
摘要:A new synthesis of 5-deazariboflavine is afforded by condensing N-D-ribityl-3,4-xylidine with a novel chemical intermediate, 6-chloro-5-formyluracil.

专利号:US-2025304580-A1
优先权日:2021-11-09
标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK; KAPLAN ALAN P; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?).This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:WO-2025128873-A1
优先权日:2023-12-12
标题:Heterocyclic pyridinone compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula (I), useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

专利号:US-2023010886-A1
优先权日:2019-09-23
标 题 :Shp2 inhibitors and uses thereof
发明人：XIE YINONG; BABISS LEE E
权利人:SUZHOU PUHE BIOPHARMA CO LTD
摘要:Compounds of Formula 1 as inhibitors of protein tyrosine phosphatase SHP2 are disclosed. The pharmaceutical compositions comprising compounds of Formula 1, methods of synthesis of these compounds, methods of treatment for diseases associated with the aberrant activity of SHP2 such as cancer using these compounds or compositions containing these compounds are also disclosed.

专利号:US-10561655-B2
优先权日:2018-03-21
标 题 :SHP2 inhibitors and uses thereof
发明人：XIE YINONG; BABISS LEE E
权利人:SYNBLIA THERAPEUTICS INC
摘要:Compounds of Formula 1 as inhibitors of protein tyrosine phosphatase SHP2 are disclosed. The pharmaceutical compositions comprising compounds of Formula 1, methods of synthesis of these compounds, methods of treatment for diseases associated with the aberrant activity of SHP2 such as cancer using these compounds or compositions containing these compounds are also disclosed.