CAS: 327031-55-0; 6-Methyl-3-(2-(1-(Pyridin-2-yl)Ethylidene)Hydrazinyl)-5H-[1,2,4]Triazino[5,6-B]Indole

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    主要参考文献


    1: Li H, Gao Y, Ni X, Xiong Y, Zhang P, Liu H, Wu X, Tong D, Wang C, Ma J. Design, synthesis and biological evaluation of 5H-[1,2,4]triazino[5,6-b]indole derivatives bearing a pyridinocycloalkyl moiety as iron chelators. Mol Divers. 2024 May 11. doi: 10.1007/s11030-024-10840-w. Epub ahead of print. 63(5):2401-2417. doi: 10.1021/acs.inorgchem.3c03259. Epub 2024 Jan 24.
    3: Reisbeck L, Linder B, Tascher G, Bozkurt S, Weber KJ, Herold-Mende C, van Wijk SJL, Marschalek R, Schaefer L, Münch C, Kögel D. The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells. Am J Physiol Cell Physiol. 2023 Dec 1;325(6):C1451-C1469. doi: 10.1152/ajpcell.00293.2023. Epub 2023 Oct 30. 11(7):2097-2121. doi: 10.21037/tcr-22-253.
    5: Jakobsson AW, Kundu S, Guo J, Chowdhury A, Zhao M, Lindell E, Bergsten P, Swartling FJ, Sjöblom T, Zhang X. Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition- Restricted Conditions. Cancers (Basel). 2022 Jun 30;14(13):3225. doi: 10.3390/cancers14133225.

    合成参考文献


    参考文献:10.1021/acs.jmedchem.0c01013
    摘要:Xu Y, Xue D, Bankhead A, Neamati N. Why All the Fuss about Oxidative Phosphorylation (OXPHOS) J. Med. Chem. 2020 Oct 26;63(23):14276–307. doi: 10.1021/acs.jmedchem.0c01013.
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