CAS: 309-88-6; N,N-Diethyl-1,1,2,3,3,3-Hexafluoropropan-1-Amine

相似化合物

311-89-7 338-84-1 432-08-6

六氟丙烯,二乙胺 以 乙醚 作为反应溶剂,化学反应 2.5H,反应生成 N,N-二乙基-1,1,2,3,3,3-六氟丙胺
参考文献:石川试剂-氟有机亚胺盐的重要来源
标题:石川试剂-氟有机亚胺盐的重要来源
摘要:我们在此报告了源自ishikawa试剂et 2 N-Cf 2-Chf-Cf 3的亚胺盐.与p(c 2 F 5)3 F 2反应,得到[et 2 N = Cf-Chf-Cf 3] [p(c 2 F 5)3 F 3],为离子液体.与sncl 2的反应表明,位于氮原子α位的阳离子中的氟原子对亲核取代反应不稳定.其中氯原子与氟发生了交换.与水接触时,氟原子被羟基取代.石川试剂与p(c 2 F 5)2 F的反应得到两性离子[p(c 2 F 5)2 F 3 {c(net 2)(chf-Cf 3)}.最有可能[et 2 N = Cf-Chf-Cf 3] [p(c 2 F 5)2 F 2]是瞬时形成的.阴离子显然具有足够的亲核性,可以攻击阳离子中易受影响的α-氟原子.在几个月的时间里,石川的试剂损失了氟化氢,它与玻璃反应反应生成sif 4,该sif 4从石川的试剂中提取了氟离子,从而提供了[et 2 N
DOI:10.1002/zaac.202000198

专利信息

专利号:US-2023286918-A1
优先权日:2020-07-02
标 题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat
发明人：JURKAUSKAS VALDAS; JUNG YOUNG CHUN; KWON TAESOO; KANNAN ARUNACHALAM; GONDI VIJAYA BHASKER
权利人:AKEBIA THERAPEUTICS INC
摘要:Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.

专利号:US-8629288-B2
优先权日:2008-02-25
标题:Method for the regioselective synthesis of 1-alky1-3-haloalkyl-pyrazole-4-carboxylic acid derivatives
发明人：PAZENOK SERGII; LUI NORBERT; HEINRICH JENS-DIETMAR; WOLLNER THOMAS
权利人:PAZENOK SERGII; LUI NORBERT; HEINRICH JENS-DIETMAR; WOLLNER THOMAS; BAYER IP GMBH
摘要:The present invention relates to a process for the regioselective synthesis of 1-alkyl-3-halo-alkylpyrazole-4-carboxylic acid derivatives by cyclization of 2,3-disubstituted acrylic acid derivatives, and to the hydrazones formed as intermediates in the process.

专利号:US-9562068-B2
优先权日:2014-10-17
标 题 :Process for the preparation of 7 α-(methoxycarbonyl)-3-OXO-17alpha-pregn-4,9(11)-dien-21,17-carbolactone, a useful intermediate for the synthesis of molecules with pharmacological activity
发明人：LENNA ROBERTO; DI BRISCO RICCARDO; BARBIERI FRANCESCO
权利人:IND CHIMICA SRL; IND CHIMICA SRL
摘要:An improved process for the preparation of intermediate (V) through the elimination of a molecule of water from intermediate (IV) is described. n nIntermediate (V) is a key molecule for the synthesis of eplerenone, a synthetic steroid with pharmacological activity used in the treatment of chronic pathological conditions, including hypertension.

专利号:WO-2025132814-A1
优先权日:2023-12-21
标 题:Novel synthesis of methyl-2-fluoroacrylate
发明人：BRUNKE JESSICA; FISCHER MICHAEL; WÖSSNER JAN STEPHAN
权利人:VIFOR INT AG
摘要:The present invention relates to novel synthesis methods of methyl 2-fluoroacrylate (MFA) which is a key precursor for the production of Veltassa® (Patiromer). The methods according to the invention are conducted by reacting an α-substituted β-hydroxy propionic acid derivative (I) via one or more intermediate steps involving one or more α-, β-substituted propionic acid derivatives (II) to obtain MFA (III).

专利号:US-12077552-B2
优先权日:2021-09-14
标 题:Synthesis of fluoroalkyl tin precursors
发明人：KUIPER DAVID
权利人:ENTEGRIS INC
摘要:The invention provides certain fluorinated alkyl tin compounds which are believed to be useful in the vapor deposition of tin-containing films onto the surface of microelectronic device substrates. Also provided are processes for the preparation of the precursor compounds and processes for the use of such compounds in the deposition of tin-containing films onto microelectronic device substrates.

专利号:US-8093421-B2
优先权日:2006-10-27
标题 :Stereoselective one step fluorination process for the preparation of 2-flouropropionate
发明人：LUI NORBERT; PAZENOK SERGII
权利人:LUI NORBERT; PAZENOK SERGII; BAYER CROPSCIENCE AG
摘要:The current invention describes a one-step process for the synthesis of 2-fluoropropionates from lactic acid ester derivatives using TFEDMA.