CAS: 23576-42-3; (S)-2-(2-(2-Amino-3-Phenylpropanamido)Acetamido)Acetic Acid

相似化合物

219677-70-0 103340-16-5 37700-64-4

上下游产品

CAS号37700-64-4 Z-PHE-GLY-GLY-OH | CAS号75720-06-8 (2S,3R,4S,5S,6R... | CAS号63-91-2 L-苯丙氨酸 | CAS号56-40-6 甘氨酸

📜N-Benzyloxycarbonyl-L-Phenylalanylglycylglycine置于palladium On Activated Charcoal 氢气体系中,用 甲醇 用作溶剂,化学反应 5.0H,反应生成L-苯丙氨酰甘氨酰甘氨酸
参考文献:Ovchinnikov,Mikhail V.; Bespalova,Zhanna D.; Molokoedov,Aleksandr S.,Collection Of Czechoslovak Chemical Communications,1989,Vol. 54,# 3,P. 784-795
标题:Ovchinnikov,Mikhail V.; Bespalova,Zhanna D.; Molokoedov,Aleksandr S.,Collection Of Czechoslovak Chemical Communications,1989,Vol. 54,# 3,P. 784-795

专利信息

专利号:US-12024731-B2
优先权日:2017-05-03
标 题 :Methods and enzyme catalysts for the synthesis of non-canonical amino acids
发明人：BOVILLE CHRISTINA E; BRINKMANN-CHEN SABINE; BULLER ANDREW R; ROMNEY DAVID K; PRIER CHRISTOPHER K; KOCH PHILIPP; SCHEELE REMKES A
权利人:CALIFORNIA INST OF TECHN
摘要:The present disclosure provides methods for preparing β-substituted tryptophan compounds. The methods include: combining i) an unsubstituted indole or a substituted indole, ii) a β-substituted serine, and iii) a tryptophan synthase β-subunit (i.e., a TrpB); and maintaining the resulting mixture under conditions sufficient to form the β-substituted tryptophan. The TrpB contains at least one amino acid mutation which promotes formation of an amino-acrylate intermediate. New TrpB variants and new β-substituted tryptophan analogs are also described.

专利号:US-6391614-B1
优先权日:1995-07-10
标题:Auxiliary gene and protein of methicillin resistant bacteria and antagonists thereof
发明人：TOMASZ ALEXANDER; DE LENCASTRE HERMINIA
权利人:UNIV ROCKEFELLER
摘要:The present invention is directed to the identification of mutant strains of methicillin resistant bacteria, in particular methicillin resistant Staphylococcus aureus , to identify the characteristics of such bacteria and develop drugs that can reverse, inhibit, or reduce bacterial resistance to beta lactam antibiotics, e.g., methicillin. The invention particularly relates to identification of a novel mutant strain of methicillin resistant S. aureus that manifests a unique phenotype, having a block in cell wall synthesis at or close to the branch point in hexose metabolism involved in the synthesis of cell wall components. Accordingly, the invention provides for methods of treatment and corresponding pharmaceutical compositions for treating bacterial, particularly staphylococcal, infections.

专利号:US-2004097717-A1
优先权日:2000-03-24
标 题:Control of aerial branching
发明人：LEYSER OTTOLINE; BOOKER JONATHAN; SOREFAN KARIM
摘要:A plant nucleic acid sequence is provided which encodes a protein involved in the synthesis of abscisic acid. The plant nucleic acid sequence, and proteins encoded thereby, are useful in the regulation of aerial branching in plants.

专利号:US-6600029-B1
优先权日:1995-12-19
标题:Metabolic engineering of polyhydroxyalkanoate monomer synthases
发明人：SHERMAN DAVID H; WILLIAMS MARK D; XUE YONGQUAN
权利人:UNIV MINNESOTA
摘要:A novel pathway for the synthesis of polyhydroxyalkanoate is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalknoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalknoate synthase.

专利号:US-2002064816-A1
优先权日:1999-12-16
标 题 :Moss genes from physcomitrella patens encoding proteins involved in the synthesis of carbohydrates
发明人：LERCHL JENS; RENZ ANDREAS; EHRHARDT THOMAS; REINDL ANDREAS; CIRPUS PETRA; BISCHOFF FRIEDRICH; FRANK MARKUS; FREUND ANNETTE; DUWENIG ELKE; SCHMIDT RALF-MICHAEL; RESKI RALF
摘要:Isolated nucleic acid molecules, designated CMRP nucleic acid molecules, which encode novel CMRPs from Physcomitrella patens are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing CMRP nucleic acid molecules, and host cells and organisms into which the expression vectors have been introduced. The invention still further provides isolated CMRPs, mutated CMRPs, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from transformed cells based on genetic engineering of CMRP genes in this organism.

专利号:US-2002049303-A1
优先权日:1999-06-28
标 题 :Catalytically active recombinant memapsin and methods of use thereof
发明人：TANG JORDAN J N; LIN XINLI; KOELSCH GERALD; HONG LIN
摘要:Methods for the production of purified, catalytically active, recombinant memapsin 2 have been developed. The substrate and subsite specificity of the catalytically active enzyme have been determined. The substrate and subsite specificity information was used to design substrate analogs of the natural memapsin 2 substrate that can inhibit the function of memapsin 2. The substrate analogs are based on peptide sequences, shown to be related to the natural peptide substrates for memapsin 2. The substrate analogs contain at least one analog of an amide bond which is not capable of being cleaved by memapsin 2. Processes for the synthesis of two substrate analogs including isosteres at the sites of the critical amino acid residues were developed and the substrate analogs, OMR99-1 and OM99-2, were synthesized. OM99-2 is based on an octapeptide Glu-Val-Asn-Leu-Ala-Ala-Glu-Phe (SEQ ID NO:28) with the Leu-Ala peptide bond substituted by a transition-state isostere hydroxyethylene group (FIG. 1 ). The inhibition constant of OM99-2 is 1.6×10 −9 M against recombinant pro-memapsin 2. Crystallography of memapsin 2 bound to this inhibitor was used to determine the three dimensional structure of the protein, as well as the importance of the various residues in binding. This information can be used by those skilled in the art to design new inhibitors, using commercially available software programs and techniques familiar to those in organic chemistry and enzymology, to design new inhibitors to memapsin 2, useful in diagnostics and for the treatment and/or prevention of Alzheimer's disease.