CAS: 2319-29-1; Decanamide

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2016-57-1 629-54-9 638-58-4

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CAS号112-31-2 癸醛 | CAS号73488-76-3 B°C-Ala-OSU | CAS号2016-57-1 正癸胺 | CAS号334-48-5 正癸酸 | CAS号143-10-2 1-硫代癸烷 | CAS号16530-70-4 azanium,decanoate | CAS号4282-40-0 1-碘庚烷 | CAS号79-06-1 丙烯酰胺 | CAS号110-42-9 癸酸甲酯 | CAS号80251-02-1 N-chlorodecanamide | CAS号2243-27-8 壬基腈 | CAS号112-30-1 正癸醇 | CAS号1975-78-6 癸腈 | CAS号1120-49-6 二癸胺 | CAS号2016-57-1 正癸胺 | CAS号112-20-9 正壬胺 | CAS号31078-36-1 癸酸香草酰胺

📜癸腈置于硫酸体系中,化学反应 12.0H,反应生成癸醯胺
参考文献:作为 Cb2 受体反向激动剂和破骨细胞抑制剂的新型双酰胺衍生物的主要发现,化学优化和生物学评价研究
标题:作为 Cb2 受体反向激动剂和破骨细胞抑制剂的新型双酰胺衍生物的主要发现,化学优化和生物学评价研究
摘要:N,N '-((4-(二甲氨基)苯基)亚甲基)双(2-苯基乙酰胺)是通过使用3D药效团数据库搜索发现的,并被生物学证实为一类新的cb 2反向激动剂.随后,在进一步的 Sar 研究中,通过修饰环 A-C 和核心结构,通过先导化学优化设计和合成了 52 种衍生物.开发了五种化合物并证实它们是 Cb 2反向激动剂,具有最高的 Cb 2结合亲和力(cb 2 K I为 22-85 Nm,Ec 50为 4-28 Nm)和最佳选择性(cb 1 /cb 2235 到 909 倍).此外,破骨细胞生成生物测定表明 Pam 化合物对破骨细胞形成有很大的抑制作用.特别是,化合物26即使在0.1 μm的低浓度下也表现出72%的抑制活性.细胞毒性试验表明,Pam 化合物对破骨细胞生成的抑制作用不是由其细胞毒性引起的.因此,这些 Pam 衍生物可作为开发新型抗骨质疏松药物的潜在先导物.
Doi:10.1021/jm301212U

专利信息

专利号:WO-9507882-A1
优先权日:1993-09-14
标 题:Synthesis of amido acids from carboxylic acid esters and amino acid salts
发明人：HEINZMAN STEPHEN WAYNE; DUPONT JEFFREY SCOTT
权利人:PROCTER & GAMBLE
摘要:Chemical synthesis of amido acids, and their conversion to amido acid phenyl ester sulfonates for use as bleach activators, starting from carboxylic acid esters and amino acid salts.

专利号:US-2012277444-A1
优先权日:2011-04-27
标 题:Synthesis of hydroxyalkyl amides from esters
发明人：MAHADEVAN SHIVKUMAR; VENKATASUBBAN KUNISI
权利人:MAHADEVAN SHIVKUMAR; VENKATASUBBAN KUNISI
摘要:Hydroxyamides are synthesized from esters. A process of making hydroxyalkyl amides comprises: reacting an ester with a hydroxyalkyl amine having the formula H 2 N—R 3 —OH wherein R 3 is a substituted or unsubstituted C2 to C5 alkyl, in the presence of a catalyst in an anhydrous solution to form the hydroxyalkyl amides. Monomers suitable for formation of polymeric articles can utilize these hydroxyamides.

专利号:US-5188769-A
优先权日:1992-03-26
标 题:Process for reducing the levels of fatty acid contaminants in polyhydroxy fatty acid amide surfactants
发明人：CONNOR DANIEL S; SCHEIBEL JEFFREY J; MURCH BRUCE P; MAO MARK H; GOSSELINK EUGENE P; SEVERSON JR ROLAND G
权利人:PROCTER & GAMBLE
摘要:The synthesis of polyhydroxy fatty acid amide surfactants exemplified by the compound C11H23C(O)N(CH3)CH2[CHOH]4CH2OH by reacting a fatty acid ester with an N-alkyl sugar amine can result in contamination of the product surfactant by residual sources of fatty acids. These residual fatty acids may be unacceptable in high sudsing detergent compositions, such as dishwashing liquids, especially with Ca or Mg cations. The process of this invention reacts such contaminants with alkyl amines or, especially, ethanolamine, to convert them into fatty alkyl- or alkanolamides, which are quite acceptable in fully-formulated detergent compositions for home or industrial use.

专利号:WO-9522519-A1
优先权日:1994-02-17
标题 :Synthesis of polyhydroxy fatty acid amides from triglycerides
发明人：SCHEIBEL JEFFREY JOHN; REILMAN RANDALL THOMAS; SHERMAN JOE FREDERICK
权利人:PROCTER & GAMBLE
摘要:Fats and oils such as hardened palm kernel oil are reacted directly with N-substituted polyhydroxy amines to provide high yields of N-substituted polyhydroxy fatty acid amide surfactants having improved odors and low fatty acid content. Hardened palm kernel oil is reacted with N-methylglucamine in the presence of an ethoxylated alcohol, but in the absence of methanol solvent, using sodium propylene glycolate catalyst to provide the mixed corresponding fatty acid amide of N-methylglucamine.

专利号:US-4780542-A
优先权日:1983-09-26
标 题:Process for the synthesis of esters and amides of carboxylic acids
发明人：LALEZARI IRAJ
权利人:MONTEFIORE MED CENTER
摘要:The invention relates to the preparation of an ester or an amide from an anhydride with an alcohol or an amine, wherein the anhydride is first prepared by reacting an acid and an alkyl chloroformate in a 100% aqueous medium, that is, 100% water.

专利号:US-5656634-A
优先权日:1991-03-21
标题 :N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT)
发明人：CHANG GEORGE; HAMANAKA ERNEST S; MCCARTHY PETER A; TRUONG THIEN V; WALKER FREDERICK J
权利人:PFIZER
摘要:Compounds of the formula ##STR1## the pharmaceutically acceptable salts thereof, wherein Q and R 1 are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.