CAS: 2140-67-2; 9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)-2-(Dimethylamino)-3,9-Dihydro-6H-Purin-6-One

上下游产品

2,N2-dimethylguanosine2′,3′,5′-tri-O-acetyl-N2,N2-dimethylguanosine dimethyl amine 6-inosine2-fluoro-O6-2-(4-nitrophenyl)ethylinosine 6-inosine2',3',5'-tris-O-acetyl-2-fluoro-O6-2-(4-nitrophenyl)ethylinosine N,N-dimethylguanosine 5'-phosphate

📜鸟苷置于palladium On Activated Charcoal 4-二甲氨基吡啶,Tetrafluoroboric Acid,四乙基氯化铵,氨,氢气,N,N-二甲基苯胺,三乙胺,Sodium Nitrite,三氯氧磷体系中,用 甲醇,水,乙腈,苯甲醇 用作溶剂,化学反应生成N2,N2-二甲基鸟苷
参考文献:Reaction Of Arylnitrenium Ions With Guanine Derivatives: N1-Methylguanosine And N2,N2-Dimethylguanosine
标题:Reaction Of Arylnitrenium Ions With Guanine Derivatives: N1-Methylguanosine And N2,N2-Dimethylguanosine
摘要:一项先前的闪光光解研究表明,芳基亚硝基离子与2'-脱氧鸟苷直接反应时产生了第二个中间体,随着瞬态亚硝基离子与核苷反应,这个中间体逐渐增加.这个中间体被确定为亚硝基离子加成到鸟嘌呤的c-8位置形成的产物,在失去c-8质子之前形成的c-8中间体.C-8中间体的一个特征是它存在酸碱形式.这种行为在光谱分析和速率-Ph曲线中都很明显,速率-Ph曲线显示在ph 4左右出现了从ph无关反应到首级h+反应的转变.本研究旨在确定共轭碱形式的结构.这涉及对由2-芴亚硝基离子与n1-甲基鸟嘌呤和n2,N2-二甲基鸟嘌呤反应产生的c-8中间体衰减的动力学研究.其理论基础是前者无法失去n-1质子,而后者无法在nh2基团上去质子.速率-Ph曲线清楚地显示n-1质子是酸性的.N2,N2-二甲基鸟嘌呤的c-8中间体的速率常数显示与2'-脱氧鸟嘌呤和鸟嘌呤相关的向共轭碱形式转变的下降变化.相比之下,N1-甲基鸟嘌呤中间体的速率常数与ph无关.还报告了形成c-8中间体的反应速率常数.这些结果表明,芳基亚硝基离子与n2,N2-二甲基鸟嘌呤衍生物的反应速度明显更快(除非反应受扩散控制).这与芳基亚硝基离子和鸟嘌呤的反应的初始步骤发生在c-8位置的直接加成一致.在这种反应中产生的正电荷可以共轭到c-2位置,π给体如nh2和nme2可以发挥稳定作用.关键词:亚硝基,芳基亚硝基,鸟苷,Dna加合物.
Doi:10.1139/v01-179

专利信息

专利号:US-2005130201-A1
优先权日:2003-10-14
标 题 :Splint-assisted enzymatic synthesis of polyribounucleotides
发明人：DERAS MICHAEL; PLEISS JEFFREY A; SCARINGE STEPHEN
权利人:DHARMACON INC
摘要:The present invention comprises methods and compositions for splint-assisted enzymatic synthesis of polyribonucleotides using an RNA polymerizing enzyme. The invention provides ligating ribonucleotides comprising ligating a donor RNA molecule to an acceptor RNA molecule in the presence of RNA ligase and a splint, wherein the donor RNA molecule is comprised of at least one nucleotide and a ligation linker moiety, the acceptor RNA molecule is comprised of at least one nucleotide and a ligation linker moiety and the splint is comprised of a polyribonucleotide. The invention also provides splints for use in splint-assisted enzymatic synthesis using an RNA polymerizing enzyme.

专利号:US-2003049619-A1
优先权日:2001-03-21
标题 :Methods for the synthesis of polynucleotides and combinatorial libraries of polynucleotides
发明人：DELAGRAVE SIMON; MARRS BARRY
摘要:Methods for the synthesis of polynucleotides and derivatives thereof are provided. Methods for the preparation of combinatorial libraries of polynucleotides are also provided. In addition, methods for the preparation and identification of polynucleotides having a predetermined property are provided.

专利号:US-7777023-B2
优先权日:1998-10-23
标题 :Method for the chemical synthesis of oligonucleotides
发明人：VARGEESE CHANDRA; SHAFFER CHRISTOPHER; WANG WEIMIN
权利人:SIRNA THERAPEUTICS INC
摘要:The present invention features novel compositions, linkers, derivatized solid supports, and methods for the efficient solid phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA chimeras, and analogs thereof.

专利号:US-2023212204-A1
优先权日:2020-01-16
标题:Reagents and their use for modular enantiodivergent synthesis of c-p bonds
发明人：XU DONGMIN; RIVAS-BASCÓN NAZARET; KNOUSE KYLE W; PADIAL NATALIA; ZHENG BIN; VANTOUROUT JULIEN; SCHMIDT MICHAEL; EASTGATE MARTIN D; BARAN PHI
权利人:BRISTOL MYERS SQUIBB CO; SCRIPPS RESEARCH INST
摘要:The disclosure describes chiral P(V)-based reagents and their uses for the modular, scalable, and stereospecific synthesis of chiral phosphines, phosphine oxides and particular oligonucleotides.

专利号:US-8759508-B2
优先权日:2007-05-18
标 题 :Chromophoric silyl protecting groups and their use in the chemical synthesis of oligonucleotides
发明人：DELANEY MICHAEL OREN
权利人:DELANEY MICHAEL OREN; GE HEALTHCARE DHARMACON INC
摘要:The compounds are of class of chromophoric 1,2,3-triazolyl equipped silyl linking groups that are useful in the chemical synthesis of RNA. An example of a nucleoside comprising this group is

专利号:US-8350022-B2
优先权日:2008-04-04
标题 :Method for the stereoselective synthesis of phosphorus compounds
发明人：MEIER CHRIS; THOMANN JENS O
权利人:UNIV HAMBURG; MEIER CHRIS; THOMANN JENS O
摘要:The present invention relates to a method for stereoselective synthesis of phosphorus compounds, whereby in the first reaction step a chiral auxiliary on the phosphorus atom of phosphoryl chloride, thiophosphoryl chloride or phosphorus trichloride is covalently bonded, the product from the first reaction step is reacted in the following step with an alcohol, thiol, or amine as the nucleophile in the presence of a base, and in the last step the chiral auxiliary is displaced from the product of the following step by a nucleophile.