专利号:US-6217901-B1 优先权日:1999-05-25 标题:Liposome-assisted synthesis of polymeric nanoparticles 发明人:PERROTT MICHAEL G; BARRY STEPHEN E 权利人:ALNIS LLC 摘要:Synthetic polymer complements (SPCs) are provided, as well as methods for their synthesis and use. The SPCs range in size from about 20 to about 1000 nm. The SPCs have surfaces that are complementary to surface sites of target molecules, resulting in the ability of the SPCs to selectively bind to molecular targets. The molecular recognition capability of these particles enables their use in diagnostic, therapeutic, and separation applications. The SPC is formed by contacting a target template molecule with a set of building blocks solubilized in the interior of a liposome, which building blocks are then polymerized into a network to form the synthetic polymer complement in the interior of the liposome. The target templates are removed to produce complementary sites in a SPC that map the surface of the target, resulting in a water-soluble SPC nanoparticle of similar dimensions as the interior of the liposome that originally supported it and capable of molecular recognition.
专利号:US-2010055187-A1 优先权日:2008-08-28 标题:Nanovitamin synthesis 发明人:AHN DONG JUNE 权利人:AHN DONG JUNE 摘要:Stable nanoparticulate vitamin compositions are prepared from agglomerated or larger sized vitamin particles of at least one vitamin compound by breaking down and/or solubilizing the agglomerated or larger sized vitamin particles and associating the particles with a surface modifying agent.
专利号:US-2004058006-A1 优先权日:1997-10-14 标 题 :High affinity nanoparticles 发明人:BARRY STEPHEN E; SOANE DAVID S 权利人:ALNIS BIOSCIENCES INC 摘要:High affinity nanoparticles are provided, as well as methods for their synthesis and use. The nanoparticles of the invention comprise high affinity molecules incorporated in a polymeric nanoparticle. The high affinity nanoparticles range in size from about 1 to about 1000 nm. The high affinity molecules of the nanoparticle have moieties that have high affinity for target molecules, resulting in the ability of the high affinity nanoparticle to selectively non-covalently bind to molecular targets. The molecular recognition capability of these particles enables their use in research, diagnostic, therapeutic, and separation applications. The nanoparticles of the invention may be formed by contacting target template molecules with a set of building blocks (which includes the high affinity molecule as one subset of the building block set), which are then polymerized into a network. Removal of the templates yields a polymeric nanoparticle with three-dimensional binding sites that are complementary in shape to at least a portion of the target and including high affinity molecules chemically anchored on the surfaces of the binding sites. The high affinity nanoparticle is then capable of molecular recognition and selective binding to target molecules when presented with the target molecule in a mixture of molecules.
参考标题:Highly Efficient Synthesis Of Monodisperse Poly(Ethylene Glycols) And Derivatives Through Macrocyclization Of Oligo(Ethylene Glycols) 作者:Hua Zhang,Xuefei Li,Qiuyan Shi,Yu Li,Guiquan Xia,Long Chen,Zhigang Yang,Zhong-Xing Jiang |发布日期:2015.3.16 摘要:A Macrocyclic Sulfate (Mcs)‐based Approach To Monodisperse Poly(Ethylene Glycols) (M‐pegs) And Their Monofunctionalized Derivatives Has Been Developed. Macrocyclization Of Oligo(Ethylene Glycols) (Oegs) Provides Mcs (Up To A 62‐membered Macrocycle) As Versatile Precursors For A Range Of Monofunctionalized M‐pegs. Through Iterative Nucleophilic Ring‐opening Reactions Of Mcs Without Performing Group
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参考文献:10.1073/pnas.1104984108 摘要:Whitney JC, Hay ID, Li C, Eckford PDW, Robinson H, Amaya MF, Wood LF, Ohman DE, Bear CE, Rehm BH, Lynne Howell P. Structural basis for alginate secretion across the bacterial outer membrane. Proc. Natl. Acad. Sci. U.S.A. 2011 Jul 21;108(32):13083–8. doi: 10.1073/pnas.1104984108.