专利号:US-7527712-B2 优先权日:2002-07-23 标 题 :Method for the continuous purification by distillation of the solvent methanol, used in the synthesis of propylene oxide 发明人:BASSLER PETER; GOEBBEL HANS-GEORG; TELES JOAQUIM HENRIQUE; RUDOLF PETER 权利人:BASF AG 摘要:Process for the continuously operated purification by distillation of the methanol used as solvent in the synthesis of propylene oxide by reaction of a hydroperoxide with propylene, with the methoxypropanols being separated off simultaneously, wherein the solvent mixture obtained in the synthesis is separated in a dividing wall column into a low-boiling fraction including methanol, an intermediate-boiling fraction containing the methoxypropanols as azeotrope with water and a high-boiling fraction including water and propylene glycol.
专利号:US-2005252762-A1 优先权日:2002-07-23 标 题:Method for the continuous purification by distillation of methanol, used as a solvent in the synthesis of propylene oxide without coupling products, with the simultaneous isolation of the methoxy propanols 发明人:BASSLER PETER; GOBBEL HANS-GEORG; TELES JOAQUIM H; RUDOLF PETER 权利人:BASF AG 摘要:Continuously operated process for the purification by distillation of the methanol used as solvent in the synthesis of propylene oxide by reaction of a hydroperoxide with propylene, with the methoxypropanols, as azcotrope with water, and the low boilers and high boilers simultaneously being separated off, wherein the solvent mixture obtained in the synthesis is fractionated in a dividing wall column.
专利号:US-7332634-B2 优先权日:2002-07-23 标题:Method for the continuous purification by distillation of 1,2-propylene glycol that accumulates during the synthesis of propylene oxide without coupling products 发明人:BASSLER PETER; GOEBBEL HANS-GEORG; TELES JOAQUIM HENRIQUE; RUDOLF PETER 权利人:BASF AG 摘要:The invention relates to a continuously operated process for the purification by distillation of the 1,2-propylene glycol formed as by-product in the synthesis of propylene oxide, wherein the mixture formed in the synthesis which contains the 1,2-propylene glycol is separated in a dividing wall column into low-, intermediate- and high-boiling fractions and the 1,2-propylene glycol is taken off as intermediate boiler at the side offtake of the column.
专利号:US-8748660-B2 优先权日:2012-07-09 标题:Process for the synthesis of antiepileptic drug lacosamide 发明人:MURUGAN MUTHUKRISHNAN; MUJAHID MOHAMMAD; MAJUMDAR PRASHANT PRAMOD 权利人:MURUGAN MUTHUKRISHNAN; MUJAHID MOHAMMAD; MAJUMDAR PRASHANT PRAMOD; COUNCIL SCIENT IND RES 摘要:The present invention relates to the improved and efficient process for the synthesis of antiepileptic drug Lacosamide in high enantiopurity (>98% ee) and better yield. More particularly, the present invention relates to improved and efficient, cost effective process for synthesis of desired (R) isomer of Lacosamide starting from commercially available (S)-benzyl glycidyl ether.
专利号:US-7825244-B2 优先权日:2005-06-10 标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis 发明人:BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG 权利人:JANSSEN PHARMACEUTICA NV 摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.
专利号:US-9475780-B2 优先权日:2011-07-20 标 题 :Process for the synthesis of cyclic alkylene ureas 发明人:GUPTA RAM; KOBYLANSKA IRINA; TREASURER URVEE; FLOOD LAWRENCE 权利人:GUPTA RAM; KOBYLANSKA IRINA; TREASURER URVEE; FLOOD LAWRENCE; ALLNEX IP S AR L 摘要:The invention relates to a process for the synthesis of cyclic alkylene ureas comprising reacting in the presence of a basic catalyst, a difunctional amine A having two primary amino groups, and an aliphatic organic carbonate component C selected from the group consisting of dialkyl carbonates CD and of alkylene carbonates CA, wherein the ratio of the amount of substance Ji(—NH2) of primary amino groups —NH2 in the difunctional amine A to the sum M(C) of the amount of substance n(CD) of carbonate groups of a dialkyl carbonate CD and the amount of substance n(CA) of carbonate groups in an alkylene carbonate CA, is at least more than 2, and to the product obtained by this process.
摘要:de Haro, T.; Garayalde, D.; Nevado, C., Science of Synthesis Knowledge Updates, (2012) 2, 176. 摘要:Kayaki, Y.; Ikariya, T., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 88. 摘要:Journal of Industrial Hygiene and Toxicology., 23(259), 1941 参考文献:10.1016/j.ijpharm.2009.12.001 摘要:Escudero JJ, Ferrero C, Jiménez-Castellanos MR. Compaction properties, drug release kinetics and fronts movement studies from matrices combining mixtures of swellable and inert polymers. II. Effect of HPMC with different degrees of methoxy/hydroxypropyl substitution. International Journal of Pharmaceutics. 2010 Mar;387(1-2):56–64. doi: 10.1016/j.ijpharm.2009.12.001.