CAS: 15231-91-1; 6-Bromo-2-Naphthol

相似化合物

91270-68-7 7385-87-7 91270-69-8

上下游产品

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2-萘酚置于tin,溴,溶剂黄146体系中,化学反应 3.0H,以92.9%的收率获得6-溴-2-萘酚
参考文献:合成的和新颖的苄基萘基砜的辐射防护作用(砜)衍生物从防爆-Rad转化†
标题:合成的和新颖的苄基萘基砜的辐射防护作用(砜)衍生物从防爆-Rad转化†
摘要:在这项工作中,设计并合成了一系列来自ex-Rad的新型苄基萘基亚砜(砜),作为潜在的辐射防护剂.其中一些化合物可有效保护huvec免受60 Coγ射线的照射,并伴有细胞毒性.与ex-Rad相比,化合物8N不仅对细胞存活和辐射诱导的dna损伤表现出显着的保护作用,而且在暴露于辐射后30天内显着提高了小鼠的存活率(100%).结果表明,某些目标化合物作为有前途的辐射防护剂,对于进一步的研究是有价值的.
Doi:10.1039/c7Md00573C

专利信息

专利号:US-4628123-A
优先权日:1984-10-23
标题:Process for the synthesis of 2-methoxy-6-bromo-naphthalene
发明人：BORSOTTI GIAMPIERO
权利人:MONTEDISON SPA
摘要:A process for the synthesis of 2-methoxy-6-bromo-naphthalene, wherein the 2-methoxy-naphthalene is brominated by means of Br 2 to 1,6-dibromo-2-methoxy-naphthalene and the latter is then dehalogenated, without any separation from the liquid medium of reaction, by addition of iron.

专利号:US-2025188022-A1
优先权日:2022-02-07
标 题 :Process for the preparation of nafamostat, camostat and their derivatives
发明人：AHMED RIYAZ; KUMAR GULSHAN; MAHAJAN SHEENA; Verma Praveen Kumar; CHAM PANKAJ SINGH; KUMAR AMIT; AHMED QAZI NAVEED; REDDY DUMBALA SRINIVASA; SHANKAR RAVI; SINGH PARVINDER PAL
权利人:COUNCIL SCIENT IND RES
摘要:The invention provides a novel, economical and practical route for the synthesis of an ester from acid and alcoholic functionalities using Trihalotriazine as coupling agent. Specifically, the invention provides a novel, economical and practical route for the preparation of Nafamostat and Camostat. Synthesis of p-guanidinobenzoic acid (Al) was also achieved from thiourea and p-aminobenzoic acid by using trihalotriazine as coupling reagent.

专利号:WO-2017083719-A1
优先权日:2015-11-13
标 题:Transition metal free methods of synthesis of biaryl compounds
发明人：GAO HONGYIN; KURTI LASZLO
权利人:UNIV RICE WILLIAM M
摘要:The present disclosure provides methods of preparing biaryl compounds which do not require transition metal catalysts. In yet another aspect, the present disclosure provides pharmaceutical compositions comprising compounds as described herein and pharmaceutically acceptable carriers.

专利号:US-7056348-B2
优先权日:2001-04-19
标题:5-aryl-1,3,3-trimethyl-2-methylene-indoline derivatives and salts thereof, methods for the production and use of said compounds for the temporary coloration of fibers
发明人：SAUTER GUIDO; BRAUN HANS-JUERGEN; REICHLIN NADIA
权利人:WELLA AG
摘要:A method for the synthesis of 5-aryl-1,3,3,-trimethyl-2-methylene-indoline derivatives of Formula (I) or its salts of Formula (Ia) wherein 1 mole of a 5-aryl-2,3,3-trimethyl-3H-indole derivative of Formula (VII) is reacted for 1 to 44 hours at a temperature of 20° to 180° C. in an apolar, aprotic or polar, protic or polar aprotic solvent with 1 to 50 moles of a compound of Formula R1-A; new compounds of Formulas (I)/(Ia) and (V), obtainable by this method as well as an agent containing at least one compound of Formula (I)/(Ia) and a carbonyl/imine compound for dyeing keratinic fibers and a method for temporarily dyeing keratin fibers, for which the keratin fiber is dyed with the aforementioned agent and the dyeing, so obtained, is removed again at any later time by a sulfite preparation.

专利号:US-4137272-A
优先权日:1976-05-04
标 题:Process for the manufacture of 2-alkoxy-6-bromo-naphthalenes
发明人：PAPENFUHS THEODOR; GENGNAGEL KURT
权利人:HOECHST AG
摘要:A new process, which can be carried out on the technical scale, had been found for the preparation of 2-alkoxy-6-bromo-naphthalenes, especially suitable as starting compounds for the synthesis of estrogens, which comprises brominating 2-hydroxy-naphthalene-1-carboxylic acid with bromine, decarboxylating the 6-bromo-2-hydroxynaphthalene-1-carboxylic acid by heating the reaction mixture at 100 - 125° C, and alkylating the 6-bromo-2-hydroxy-naphthalene formed. The process can be conducted easily and with high yields.

专利号:US-11718596-B2
优先权日:2014-03-19
标题 :Amyloid targeting agents and methods of using the same
发明人：YANG JERRY; THEODORAKIS EMMANUEL A; SARRAF STELLA
权利人:UNIV CALIFORNIA; AMYDIS INC
摘要:Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.