CAS: 147688-58-2; 2,2-Dimethylmorpholine

相似化合物

167946-94-3 19151-69-0 113889-14-8

专利信息

专利号:US-5859233-A
优先权日:1996-02-21
标 题 :Synthons for synthesis of oligonucleotide N3-P5 phosphoramidates
发明人：HIRSCHBEIN BERNARD L; FEARON KAREN L; GRYAZNOV SERGEI M; MCCURDY SARAH N; NELSON JEFFREY S; SCHULTZ RONALD G
权利人:LYNX THERAPEUTICS INC
摘要:The invention provides a method of synthesizing oligonucleotide N3'->P5' phosphoramidates using an amine-exchange reaction of phosphoramidites in which a -deprotected 3'-amino group of a solid phase supported oligonucleotide chain is exhanged for the amino portion of a 5'-phosphoramidite of an incoming monomer which has a protected 3'-amino group. The resulting internucleotide phosphoramidite linkage is then oxidized to form a stable protected phosphoramidate linkage. The method of the invention greatly improves product yields and reduces reagent usage over currently available methods for synthesizing the above class of compound.

专利号:US-5824793-A
优先权日:1996-02-21
标题:Solid phase synthesis of oligonucleotide N3'-P5' phosphoramidates
发明人：HIRSCHBEIN BERNARD L; FEARON KAREN L; GRYAZNOV SERGEI M; MCCURDY SARAH N; NELSON JEFFERY S; SCHULTZ RONALD G
权利人:LYNX THERAPEUTICS INC
摘要:The invention provides a method of synthesizing oligonucleotide N3'->P5' phosphoramidates using an amine-exchange reaction of phosphoramidites in which a deprotected 3'-amino group of a solid phase supported oligonucleotide chain is exhanged for the amino portion of a 5'-phosphoramidite of an incoming monomer which has a protected 3'-amino group. The resulting internucleotide phosphoramidite linkage is then oxidized to form a stable protected phosphoramidate linkage. The method of the invention greatly improves product yields and reduces reagent usage over currently available methods for synthesizing the above class of compound.

专利号:US-9522896-B2
优先权日:2014-12-04
标题 :Organo-1-oxa-4-azonium cyclohexane compounds
发明人：NICHOLAS CHRISTOPHER P; MILLER MARK A; GALEY MELISSA M; YUHAS BENJAMIN D; PRABHAKAR SESH
权利人:UOP LLC
摘要:Novel 1-oxa-4-azonium cyclohexane salts are described. These compounds can be used as structure directing agents, and they overcome many of the typical problems associated with OSDA synthesis and subsequent zeolite synthesis. Methods for synthesis of the 1-oxa-4-azonium cyclohexane salts from a variety of starting materials are also described. A substituted hydrocarbon is added to water to form a mixture, and a 1-oxa-4-azacyclohexane derivative is then added. The reaction mixture stirred until a solution containing the 1-oxa-4-azonium cyclohexane salt is obtained.

专利号:US-10633355-B2
优先权日:2014-12-04
标题:Organo-1-oxa-4-azonium cyclohexane compounds
发明人：NICHOLAS CHRISTOPHER P; MILLER MARK A; GALEY MELISSA M; YUHAS BENJAMIN D; PRABHAKAR SESH
权利人:UOP LLC
摘要:Novel 1-oxa-4-azonium cyclohexane salts are described. These compounds can be used as structure directing agents, and they overcome many of the typical problems associated with OSDA synthesis and subsequent zeolite synthesis. Methods for synthesis of the 1-oxa-4-azonium cyclohexane salts from a variety of starting materials are also described. A substituted hydrocarbon is added to water to form a mixture, and a 1-oxa-4-azacyclohexane derivative is then added. The reaction mixture stirred until a solution containing the 1-oxa-4-azonium cyclohexane salt is obtained.

专利号:US-10597373-B2
优先权日:2014-12-04
标题 :Organo-1-oxa-4-azonium cyclohexane compounds
发明人：NICHOLAS CHRISTOPHER P; MILLER MARK A; GALEY MELISSA M; YUHAS BENJAMIN D; PRABHAKAR SESH
权利人:UOP LLC
摘要:Novel 1-oxa-4-azonium cyclohexane salts are described. These compounds can be used as structure directing agents, and they overcome many of the typical problems associated with OSDA synthesis and subsequent zeolite synthesis. Methods for synthesis of the 1-oxa-4-azonium cyclohexane salts from a variety of starting materials are also described. A substituted hydrocarbon is added to water to form a mixture, and a 1-oxa-4-azacyclohexane derivative is then added. The reaction mixture stirred until a solution containing the 1-oxa-4-azonium cyclohexane salt is obtained.

专利号:US-10654817-B2
优先权日:2014-12-04
标题 :Organo-1-oxa-4-azonium cyclohexane compounds
发明人：NICHOLAS CHRISTOPHER P; MILLER MARK A; GALEY MELISSA M; YUHAS BENJAMIN D; PRABHAKAR SESH
权利人:UOP LLC
摘要:Novel 1-oxa-4-azonium cyclohexane salts are described. These compounds can be used as structure directing agents, and they overcome many of the typical problems associated with OSDA synthesis and subsequent zeolite synthesis. Methods for synthesis of the 1-oxa-4-azonium cyclohexane salts from a variety of starting materials are also described. A substituted hydrocarbon is added to water to form a mixture, and a 1-oxa-4-azacyclohexane derivative is then added. The reaction mixture stirred until a solution containing the 1-oxa-4-azonium cyclohexane salt is obtained.