CAS: 13341-72-5; (±)-Mintlactone

该化合物是一种环形氯酮衍生物,其核心结构为苯丙胺,其特点是三氯酮化合物部分氢化呋喃环和三六位置的甲基替代物,影响其反应性和稳定性,主要用作有机合成的中间体,特别是用于发展香气,制药和农用化学品.饱和环环系统提高了其与减少和功能化反应的兼容性,而碳基组则为进一步衍生提供了多功能性.其界定明确的结构和纯度使其适合于需要精确分子框架的研究和工业应用.

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15356-74-8 17092-92-1 81800-41-1

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上下游产品

propionateEthyl 2-1-(ethoxycarbonyl)-4-methyl-2-ox°Cyclohexylpropionate 2-(2-diethoxyphosphoryl)propionyloxy-4-methylcyclohexanone 2-hydroxy-4-methylcyclohexanone 2-acetoxy-4-methylcyclohexanonementhofuran 2-(4-Methyl-1-cyclohexenyl)-1,2-propanediol methyl-4 cyclohexenyl-1 methyle cetone (+/-)-3,6-dimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one

合成工艺路线路线简述

    📜2-Acetoxy-4-Methylcyclohexanone置于吡啶,水,Sodium Hydride,Potassium Carbonate体系中,用 四氢呋喃,甲醇,苯 用作溶剂,化学反应 10.25H,反应生成薄荷内酯
    参考文献:A Facile Synthesis Of (+/-)-Mintlactone
    标题:A Facile Synthesis Of (+/-)-Mintlactone
    摘要:(+/-)-薄荷内酯通过应用一种新的有效的合成序列被成功合成.4-甲基环己酮经由醋酸酐化(使用醋酸铅作为催化剂),随后进行水解处理,并与2-氯丙酰氯反应.接着,通过三氯化磷进行处理,最后经历horner-Emmons型分子内环化反应,最终得到(+/-)-薄荷内酯.
    Doi:10.1080/00397919708005649

    海关参考信息

    专利信息


    专利号:US-11434216-B2
    优先权日:2015-09-11
    标题 :Preparation of 3-hydroxy-3,6-dimethylhexahydrobenzofuran-2-one and derivatives thereof
    发明人：FOLEY PATRICK; YANG YONGHUA; SALAM TANIA
    权利人:P2 SCIENCE INC
    摘要:The present invention relates to the synthesis of intermediate compounds which can be used in the synthesis of mint lactone and related compounds, including 3,6-dimethylhexahydrobenzofuran-2-ones, isomers, and other derivatives.

    专利号:US-10995080-B2
    优先权日:2019-05-31
    标题 :Stereoselective synthesis of perhydro-3,6-dialkyl-2-benzo[b]furanones and analogs
    发明人：BECKER YIGAL; CHESKIS MICHAEL
    权利人:INT FLAVORS & FRAGRANCES INC
    摘要:Synthetic methods of preparing perhydro-3,6-dimethyl-2-benzo[b]furanones, in particular dihydromintlactone, and analogs through reaction of dehydrogenation of menthanediols and analogs with a base in the presence of (carbonylchlorohydrido[bis-(2-diphenylphosphinoethyl)amine]ruthenium(II) as catalyst in good stereoselectivity and yields under stereochemistry controlled conditions are disclosed.

    专利号:US-2020377466-A1
    优先权日:2019-05-31
    标题:Stereoselective synthesis of perhydro-3,6-dialkyl-2-benzo[b]furanones and analogs

    专利号:EP-4340951-A1
    优先权日:2021-05-19
    标题:Skin care compositions comprising nano-elements of collagen-synthesis stimulating compounds and methods of preparing the same

    专利号:CA-3218545-A1
    优先权日:2021-05-19
    标题:Skin care compositions comprising nano-elements of collagen-synthesis stimulating compounds and methods of preparing the same

    专利号:CN-117396184-A
    优先权日:2021-05-19
    标 题:Skin care compositions containing nanoelements of collagen synthesis stimulating compounds and methods of preparing the same

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    合成参考文献


    参考文献:10.1007/s42535-023-00572-x
    摘要:Amalich S, Zerkani H, Tagnaout I, Ali C, Kamal F, Zair T. Chemical composition of the essential oil and isolation of two main constituents of Mentha pulegium L. Vegetos. 2023 Jan 21;37(1):82–93. doi: 10.1007/s42535-023-00572-x.
    参考文献:10.1007/s11694-025-03097-w
    摘要:Seker I, Karlidag S, Akyol A, Yil G, Koseman A, Uyumlu AB, Erdogan S, Yilmaztekin M. Volatile organic compounds of royal jellies obtained from honeybee (Apis mellifera L.) colonies fed with different industrial sugars at different locations. Food Measure. 2025 Jan 20;19(3):2019–34. doi: 10.1007/s11694-025-03097-w.
    参考文献:10.1007/s44371-025-00465-9
    摘要:Wong FJ, Shah MD, Chong WS, Yong YS, Gnanaraj C, Rossita S, Nurzafirah M, Lee W. Metabolites composition and therapeutic potential of rhizophoraceae mangroves in Asia: a review. Discov. Chem. 2026 Jan 08;3(1). doi: 10.1007/s44371-025-00465-9.
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