(二甲氨基)乙腈置于乙醇,Sodium,甲苯体系中,化学反应生成N,N-二甲基乙二胺 参考文献:Welvart,Bulletin De La Societe Chimique De France,1955,P. 218 标题:Welvart,Bulletin De La Societe Chimique De France,1955,P. 218
专利信息
专利号:WO-9837078-A1 优先权日:1997-02-20 标题 :Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes 发明人:DOERWALD FLORENCIO ZARAGOZA 权利人:NOVO NORDISK AS 摘要:A solid phase method for the synthesis of a plurality of differently substituted thiophenes with a wide variety of side-chain substituents as compounds of potential therapeutic interest. The thiophenes are prepared by reaction of a substrate-bound primary or secondary amine with a thiophosgene equivalent and reaction of the resulting intermediate with an acceptor-substituted acetonitrile in the presence of a base. Alkylation with an appropriate alkyl halide, followed by Thorpe-Ziegler-cyclization yields differently substituted, support-bound 3-aminothiophenes. These may be screened on the substrate or cleaved from the substrate and then screened in solution. Alternatively, the resin-bound 3-amino thiophenes or the synthetic intermediates can be subjected to further synthetic transformations (N-acylation, reduction) on the support, which permits the preparation of further therapeutically interesting compounds. The efficient synthesis of a wide variety of thiophenes using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse thiophene-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.
专利号:US-7901664-B2 优先权日:2008-03-31 标题 :Synthesis of aluminophosphate and metalloaluminophosphate molecular sieves 发明人:CAO GUANG; AFEWORKI MOBAE; SHAH MATU J; MERTENS MACHTELD MARIA 权利人:EXXONMOBIL CHEM PATENTS INC 摘要:In a method of synthesizing an aluminophosphate or metalloaluminophosphate molecular sieve, a synthesis mixture is provided comprising water, a source of aluminum, a source of phosphorus, optionally a source of a metal other than aluminum, a tertiary amine, and an alkylating agent capable of reacting with said tertiary amine to form a quaternary ammonium compound capable of directing the synthesis of said molecular sieve. The synthesis mixture is maintained under conditions sufficient to cause the alkylating agent to react with the tertiary amine to produce the quaternary ammonium compound and to induce crystallization of the molecular sieve.
专利号:US-6620983-B1 优先权日:2002-06-12 标 题 :Synthesis of aluminophosphates and silicoaluminophosphates 发明人:CAO GUANG; SHAH MATU J; STROHMAIER KARL G; HALL RICHARD B 权利人:EXXONMOBIL CHEM PATENTS INC 摘要:The invention is directed to a method of synthesizing aluminophosphate or silicoaluminophosphate molecular sieves and in particular to the synthesis of silicoaluminophosphate molecular sieves using synthesis templates in combination with a source of fluoride comprising at least two fluoride substituents. The use of such fluorine containing compounds results in good quality low silica SAPO molecular sieves of CHA framework type.
专利号:WO-2015193910-A1 优先权日:2014-06-20 标题:Asymmetric synthesis of 2-substituted indolines and 3-substituted cinnolines 发明人:KUMAR BOOPATHY SENTHIL; SUDALAI ARUMUGAM 权利人:COUNCIL SCIENT IND RES 摘要:The present invention relates to a novel one step proline catalyzed process for synthesis of chiral hydrazine and its derivatives from o-bromo hydro cinamaldehyde. Further, it relates to a novel one step process for the synthesis of substitued indolines and cinnolines from chiral hydrazines and its derivatives.
专利号:US-8735586-B2 优先权日:2007-06-26 标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles 发明人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR 权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA 摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.
专利号:US-8048402-B2 优先权日:2005-08-18 标题:Synthesis of molecular sieves having the chabazite framework type and their use in the conversion of oxygenates to olefins 发明人:CAO GUANG; SHAH MATU J 权利人:EXXONMOBIL CHEM PATENTS INC 摘要:The synthesis of a crystalline aluminophosphate or silicoaluminophosphate molecular sieve having a chabazite-type framework type is conducted in the presence of an organic directing agent having the formula (I)n n[R 1 R 2 R 3 N—R 4 ] + X −   (I)n nwherein R 1 , R 2 and R 3 are independently selected from the group consisting of alkyl groups having from 1 to 3 carbon atoms and hydroxyalkyl groups having from 1 to 3 carbon atoms; R 4 is selected from the group consisting of 4- to 8-membered cycloalkyl groups, optionally substituted by 1 to 3 alkyl groups having from 1 to 3 carbon atoms; 4- to 8-membered heterocyclic groups having from 1 to 3 heteroatoms, said heterocyclic groups being optionally substituted by 1 to 3 alkyl groups having from 1 to 3 carbon atoms and the heteroatoms in said heterocyclic groups being selected from the group consisting of O, N, and S; and aromatic groups optionally substituted by 1 to 3 alkyl groups, said alkyl groups having from 1 to 3 carbon atoms; and X − is an anion.
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 246. 摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 112. 摘要:Silva, V. L. M.; Pinto, D. C. G. A.; Santos, C. M. M.; Rocha, D. H. A., Science of Synthesis Knowledge Updates, (2022) 3, 252. 摘要:Krishnamoorthy, R., Science of Synthesis Knowledge Updates, (2013) 1, 461. 摘要:Osuna Gálvez, A.; Bode, J. W., Science of Synthesis Knowledge Updates, (2020) 1, 386.