CAS: 1000339-52-5; 3-Fluoro-2-Nitrobenzonitrile
该化合物是一种有机化合物,其特点是存在氟原子,硝基化合物和附于苯环的硝三联功能组;分子结构的特点是一个苯环,其代成位置为氟(3个位置),而一个位于正方位(2个位置)的硝基化合物,相对于硝基子组而言,该化合物一般是一种固体,在室内温度下可能表现出黄色到浅色.已知该化合物在制药和农用化学中的潜在用途,因为硝基和硝基化合物都具有回活动性,可参与各种化学反应.氟基原子的存在可增强化合物的脂性和生物活动.与许多硝基化合物一样,它可能构成某些危害,包括毒性和环境关切,需要小心处理和处置.
相似化合物
1000339-51-4 115661-37-5 872366-63-7物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS06;
注释: Skull and crossbones - 危险类别急性毒性 类别3(吸入)
急性毒性 类别3(经皮)
急性毒性 类别3(经口)
急性毒性 类别4(吸入)
急性毒性 类别4(经皮)
特定目标器官毒性 - 单次接触 类别3
皮肤腐蚀/刺激 类别2
严重眼刺激 类别2A - 警示词Danger(危险)
- 危险描述H331 |吸入会中毒.
H311 |皮肤接触会中毒.
H301 |吞咽会中毒.
H332 |吸入有害.
H312 |皮肤接触有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激. - 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
- 安全声明H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
欧盟法规
ECHA物质C&L通报上下游产品
2bromo6fluoronitrobenzenemethyl 5-(3-cyano-2-nitrophenylamino)thiophene-2-carboxylate合成工艺路线路线简述
📜Copper(L) Cyanide,2-溴-6-氟硝基苯 以 N,N-二甲基甲酰胺 用作溶剂,化学反应 1.0H,以81%的收率获得3-氟-2-硝基苯腈
参考文献:Optimization Of Potent Inhibitors Of P. Falciparum Dihydroorotate Dehydrogenase For The Treatment Of Malaria
标题:Optimization Of Potent Inhibitors Of P. Falciparum Dihydroorotate Dehydrogenase For The Treatment Of Malaria
摘要:Inhibition Of Dihydroorotate Dehydrogenase (Dhodh) For P. Falciparum Potentially Represents A New Treatment Option For Malaria,Since Dhodh Catalyzes The Rate-Limiting Step In The Pyrimidine Biosynthetic Pathway And P. Falciparum Is Unable To Salvage Pyrimidines And Must Rely On De Novo Biosynthesis For Survival. We Report Herein The Synthesis And Structure-Activity Relationship Of A Series Of 5-(2-Methylbenzimidazol-1-yl)-N-Alkylthiophene-2-Carboxamides That Are Potent Inhibitors Against Pfdhodh But Do Not Inhibit The Human Enzyme. On The Basis Of Efficacy Observed In Three Mouse Models Of Malaria,Acceptable Safety Pharmacology Risk Assessment And Safety Toxicology Profile In Rodents,Lack Of Potential Drug-Drug Interactions,Acceptable Adme/pharmacokinetic Profile,And Projected Human Dose,5-(4-Cyano-2-Methyl-1H-Benzo[d]Imidazol-1-yl)-N-Cyclopropylthiophene-2-Carboxamide 2Q Was Identified As A Potential Drug Development Candidate.
Doi:10.1021/ml200143C
专利信息
专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).
专利号:US-2023128195-A1
优先权日:2017-07-06
标 题:Synthesis of halichondrins
专利号:KR-20220124279-A
优先权日:2017-07-06
标题 :Synthesis of Halicondrin
专利号:CN-118515685-A
优先权日:2017-07-06
标题 :Synthesis of halichondrin
专利号:CA-3069160-C
优先权日:2017-07-06
标题:Synthesis of halichondrins
专利号:CN-111433211-B
优先权日:2017-07-06
标题 :Synthesis of Halichondrin
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
合成方法参考DOI号:10.1021/ml200143c
📝 需求与反馈
尽可能描述清楚需求与问题信息
