CAS: 98-60-2; 4-Chlorobenzenesulfonyl Chloride

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对氯苯胺置于盐酸,Sodium Nitrite,氯化亚砜,水,Copper(L) Chloride体系中,用 水 作为反应溶剂,化学反应 4.75H,以67.2%的收率获得产物4-氯苯磺酰氯
参考文献:水工艺化学:芳基磺酰氯的制备
标题:水工艺化学:芳基磺酰氯的制备
摘要:与推荐的文献方法相比,使用酸性水溶液在铜盐,优选cucl和亚硫酰氯作为二氧化硫源的情况下,从重氮盐制备芳基磺酰氯具有显着的优势,优于推荐的文献方法,在乙酸中进行反应酸,使溶剂中的水含量降至最低.已经证明该方法对于多种电子不足和电子中性的芳基底物是成功的.磺酰氯在水中的低溶解度可保护其免受水解,从而使其以非常好的收率(> 70%)和高强度(> 98%w / W)从反应混合物中直接沉淀出来.水性工艺更安全,更耐用,可以轻松扩大规模,并具有明显的环境效益.
DOI:10.1021/op9000862

专利信息

专利号:US-5276196-A
优先权日:1992-03-09
标题:Synthesis of bis(haloarylsulfonyl) aromatics
发明人：HOLBA ALBERT G; STRAW JIM J; HERD MEL D
权利人:PHILLIPS PETROLEUM CO
摘要:This invention relates to the synthesis of bis(haloarylsulfonyl) aromatic compounds and more specifically, bis(chlorophenylsulfonyl) aromatic compounds. Bis(chlorophenylsulfonyl) aromatic compounds and particularly 4,4'-bis(4-chlorophenylsulfonyl)biphenyl are frequently used as monomers and comonomers in making high temperature polymers which possess glass transition temperatures greater than 260 degrees C. A process has been developed wherein product of high purity and minimal iron contamination is produced by reacting haloarylsulfonyl halide with an aromatic compound in the presence of an appropriate catalyst with and without solvent.

专利号:US-4594426-A
优先权日:1980-01-17
标题 :Benzoxazole derivative intermediates for synthesis of dye releasing redox compounds
发明人：FUJITA SHINSAKU; KOYAMA KOICHI; INAGAKI YOSHIO
权利人:FUJI PHOTO FILM CO LTD
摘要:Benzoxazole derivatives represented by general formula (I) which are intermediates for synthesis of o-sulfonamidophenol derivatives useful as dye releasing redox compounds in a color diffusion transfer color image forming process: ##STR1## wherein R 1 and R 2 , which may be the same as or different from each other, each represents an alkyl group or an aryl group or they may combine and form a ring; R 3 represents a hydrogen atom, an alkyl group or an aryl group; R 4 represents an alkyl group or an aryl group; R 5 represents an alkyl group, an alkoxy group, an alkylthio group, an arylthio group, a halogen atom or an acylamino group, or --CR 1 R 2 R 3 and R 5 may combine and form the nucleus ##STR2## which is condensed at the 6- and the 7-positions of the benzoxazole nucleus; and n is 0, 1 or 2.

专利号:WO-9849181-A1
优先权日:1997-04-30
标题:Novel sulfur transfer reagents for oligonucleotide synthesis
发明人：TANG JIN YAN; ZHANG ZHAODA; NICHOLS ALEXANDRA
权利人:HYBRIDON INC
摘要:The invention relates to the chemical synthesis of oligonucleotides and to chemical entities useful in such synthesis. More particularly, the invention relates to sulfurization of the internucleoside linkages of oligonucleotides. The invention provides new sulfur transfer reagents of formula (1) and processes for their use in sulfurizing oligonucleotides. The sulfur transfer reagents according to the invention are inexpensive to make, stable in storage, and highly efficient in sulfurization. In Formula (1) n = 1 to 4, and wherein R can be the same as or different from R1, and wherein R and R1 are selected from the group consisting of CH¿3?, CH2CH3, tert-butyl, Formula (2), (3), (4), wherein R?2, R3 and R4¿, are selected from the group consisting of Cl, Br, I, CN, NO¿2?, CH3, and CH2CH3, and wherein R?1, R2, R3 and R4¿, taken separately are hydrogen, lower alkyl, electron-withdrawing substituted lower alkyl, lower alkyl- or halo-substituted aryl, or a heterocycle containing nitrogen, oxygen, or sulfur and from 5-8 carbon atoms.

专利号:US-2011124867-A1
优先权日:2007-12-18
标题 :Process and intermediates for the Synthesis of heterocyclic Substituted Piperazines with CXCR3 Antagonist Activity
发明人：CHEN FRANK XING; CUTARELLI TIMOTHY D; FU XIAYONG; LIANG XIAN; MCALLISTER TIMOTHY L; ORR ROBERT K; YIN JIANGUO; YONG KELVIN H; ZHU MAN
权利人:SCHERING CORP
摘要:The present invention relates to novel processes for the preparation of the compound of the Formula A45: n n n n n n n n n n or a physiologically acceptable salt, solvate or prodrug thereof, which has utility, for example, as a pharmaceutically active compound with CXCR3 antagonist activity, and to novel intermediates useful in the synthesis thereof.

专利号:US-8178672-B2
优先权日:2004-10-19
标 题:Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 MAP kinase
发明人：ASHWELL MARK A; TANDON MANISH; LAPIERRE JEAN-MARC
权利人:ASHWELL MARK A; TANDON MANISH; LAPIERRE JEAN-MARC; ARQULE INC
摘要:An efficient route for the synthesis is of formula (I) of imidazooxazole and imidazothiazole inhibitors of the p38 MAP kinase pathway, useful as therapeutics for disease conditions including inflammation and auto-immune responses is described.

专利号:US-3839325-A
优先权日:1973-03-23
标题:Synthesis of 4-sulfonamidophenyl hydrazines
发明人：HOFFSTADT W
权利人:GAF CORP
摘要:A synthesis is disclosed utilizing p-chlorobenzene-sulfonamide compounds of the following formula: IN WHICH R and R1 independently represent hydrogen, alkyl, hydroxyalkyl, cycloalkyl, alkaryl, aralkyl or aryl, which may or may not be further substituted, or together with the nitrogen atom form a heterocyclic ring. These compounds are dissolved in dimethyl sulfoxide (DMSO), mixed with aqueous hydrazine hydrate and heated until completely reacted to form 4 - sulfonamidophenyl hydrazines that can be readily separated from the reaction media by precipitation with water. The precipitate can be readily washed and dried to provide a pure, substituted sulfonamido hydrazine. The product is obtained in high yields frequently of about 80 - 90 percent and is sufficiently pure for subsequent use in the preparation of substituted phenyl pyrazolones which in turn are useful as magenta color formers in color photography. For example, p-chloro-benzene-sulfonyl morpholine is dissolved in DMSO and reacted under reflux conditions with aqueous hydrazine hydrate to form 4 - morpholino - sulfonamido-phenyl hydrazine having a melting point of 162*- 164*C after purification.