CAS: 903522-29-2; 3,5-Difluoroisonicotinic Acid

相似化合物

1214377-09-9 870234-98-3 393-53-3

上下游产品

ethyl acetate 3,5-difluoropyridine N-{1-[(2,4-dichlorophenyl)methyl]-1H-pyrazol-3-yl}-3,5-difluoro-4-pyridinecarboxamide 3-fluoro-5-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid 3-fluoro-5-[(2-fluoro-4-iodophenyl)amino]isonicotinamide 3-[(2-fluoro-4-iodophenyl)amino]-5-[(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)oxy]isonicotinamide

在 三乙基硅烷,三氟乙酸体系中,用 二氯甲烷 作为反应溶剂,以65 %的收率获得产物3,5-二氟吡啶-4-甲酸
参考文献:一种异烟酸衍生物的制备方法
标题:一种异烟酸衍生物的制备方法
摘要:本发明提供了一种异烟酸衍生物的制备方法,所述制备方法包括如下步骤:(1)将式i所示化合物在二异丙基氨基锂的存在下,与二碳酸二叔丁酯在溶剂中反应得到式ii所示化合物;(2)将式ii所示化合物在溶剂中,经过与三氟乙酸,三乙基硅烷的反应后,得到所述式iii所示化合物,即异烟酸衍生物;本发明提供的合成异烟酸衍生物的新思路,相比较于传统的直接通入二氧化碳和直接投入干冰的方式,该方法几乎不会有副产物的产生,且该方法操作处理简单,对实验条件要求较低,试剂原料成本较低,绿色环保,符合现代有机化学发展的理念.

专利信息

专利号:US-11286268-B1
优先权日:2019-07-02
标题:EIF4E-inhibiting compounds and methods
发明人：SPERRY SAMUEL; XIANG ALAN X; ERNST JUSTIN T; REICH SIEGFRIED H; SPRENGELER PAUL A; SHAGHAFI MIKE; MICHELS THEO; NILEWSKI CHRISTIAN; TRAN CHINH VIET; PACKARD Garrick Kenneth; GRUBBS ALAN; URKALAN KAVERI; MUKAIYAMA TAKASUKE
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n n n n n n n n n n For Formula I compounds X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , Q, L 1 , L 2 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and rings A, B and C are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4e and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.