CAS: 89943-82-8; 3-(4-Chlorophenyl)-6-Methyl-1,3-Dihydrofuro[3,4-C]Pyridin-7-Ol

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(+/-)-4-氯苯基-5-[(3,4-异丙基亚基)-2-甲基吡啶]甲醇 (+)-2,2,8-Trimethyl-5-(4-Chloro-α-Hydroxybenzyl)-Pyrido-[4,3-E]-1,3-Dioxane 133545-64-9

📜Methyl (2S,3R,4S,5R,6R)-3,4,5-Triacetyloxy-6-[[3-(4-Chlorophenyl)-6-Methyl-1,3-Dihydrofuro[3,4-C]Pyridin-7-Yl]Oxy]Oxane-2-Carboxylate 反应生成 西氯他宁
参考文献:Esanu,Andre;Eck,Charles
标题:Esanu,Andre;Eck,Charles

专利信息

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:US-5043448-A
优先权日:1989-07-27
标 题:Asymmetric synthesis of furo(3,4-c) pyridine derivatives
发明人：ECK CHARLES
权利人:SCRAS
摘要:The invention relates to a method for the preparation of a non-racemic furo [3,4-c] pyridine derivatives of the formula I ##STR1## wherein R 1 , R 2 and R 3 stand for various substitutents, comprising adding a concentrated strong acid to a solution of a non-racemic compound of the formula II ##STR2## in an amount sufficient to catalyze a deprotection/cyclodehydration. These compounds are known antihypertensives.

专利号:AT-399151-B
优先权日:1989-07-27
标题:ASYMMETRICAL SYNTHESIS OF FURO (3,4-C) PYRIDINE DERIVATIVES

专利号:CN-101678118-A
优先权日:2006-10-05
标 题:Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:NL-9001612-A
优先权日:1989-07-27
标 题:ASYMMETRICAL SYNTHESIS OF FURO3,4-C PYRIDINE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THE NON-RACEMIC, PHARMACEUTICALLY ACTIVE DERIVATIVES.

专利号:SE-509680-C2
优先权日:1989-07-27
标 题:Asymmetric synthesis of furo (3,4-c) pyridine derivatives