CAS: 813-77-4; Dimethyl Chlorophosphate

该化合物是有机磷化合物,其化学结构包括两个甲基组和一个氯磷酸盐功能组,其颜色无色可粉黄,有刺眼的气味,以高反应性闻名,特别是由于存在氯磷酸盐,该化合物主要用作各种化学品合成的中间体,包括农药和药品,还因其作为化学战剂的潜力而得到承认,这引起了人们对其毒性和环境影响的关切.二甲基氯磷酸盐在有机溶剂中可溶解,但在水中溶解性有限.在处理该物质时,必须采取安全防范措施,因为吸入,摄取或通过皮肤吸收该物质会有害.适当的储存和处置方法对于减轻其使用的风险至关重要.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号96-36-6 Methyl phosphit... | CAS号868-85-9 亚磷酸二甲酯 | CAS号67-56-1 甲醇 | CAS号121-45-9 亚磷酸三甲酯 | CAS号3743-07-5 DIMETHYLCHLOROP... | CAS号71954-24-0 N-chloro-N-meth... | CAS号75-07-0 乙醛 | CAS号545-06-2 三氯乙腈 | CAS号56-23-5 四氯化碳 | CAS号124-41-4 甲醇钠 | CAS号1474-74-4 Diphosphoric ac... | CAS号950-35-6 甲基对氧磷 | CAS号18264-30-7 (4-chlorophenyl... | CAS号20465-00-3 N-dimethoxyphos... | CAS号20465-01-4 N-dimethoxyphos... | CAS号779-02-2 9-甲基蒽 | CAS号512-56-1 磷酸三甲酯 | CAS号813-78-5 磷酸二甲酯 | CAS号10463-05-5 DIMETHYLETHYLPH... | CAS号27122-74-3 (2-methoxypheny...

合成工艺路线路线简述

  • 合成目标产物 Dimethyl Phosphorochloridate 主要起始原料 Methanol
  • (文献来源)合成步骤主要原料 Methanol
亚磷酸二甲酯置于四氯化碳,苄基三乙基氯化铵,Potassium Carbonate体系中,用 甲苯 作为反应溶剂,化学反应生成 氯磷酸二甲酯
参考文献:磷酸,磺酸和羧酸的氯化物在 Ptc 条件下在固体碳酸钾表面上的反应
标题:磷酸,磺酸和羧酸的氯化物在 Ptc 条件下在固体碳酸钾表面上的反应
摘要:磷酸 (4) 和羧酸 (6) 酸酐的简单合成已经通过相转移催化酰化中的固体碳酸钾进行了阐述.在亲脂性季铵盐存在下,还研究了各种酰氯,磷酸 (1),磺酸 (2) 和羧酸 (8) 对碳酸钾的行为.© 2004 Wiley Periodicals,Inc. 杂原子化学 15:447-450,2004; 在线发表于 Wiley Interscience (Www.Interscience.Wiley.Com).doi 10.1002/hc.20039
DOI:10.1002/hc.20039

海关参考信息

专利信息


专利号:US-8420848-B2
优先权日:2009-01-09
标题:Process for the synthesis of beta glycerol phosphate
发明人:KULKARNI YASHWANT
权利人:KULKARNI YASHWANT; SIGMA ALDRICH CO LLC
摘要:The present invention provides methods for the preparation of beta glycerol phosphate and its salts. In particular, the invention provides efficient methods for the synthesis of beta glycerol phosphate of high purity.

专利号:US-6610802-B2
优先权日:2001-05-29
标题 :Process for synthesis of polymer compositions, polymer compositionS obtainable by the process, and use of the same
发明人:ROOS SEBASTIAN; EISENBERG BORIS; HARPE CAROLIN
权利人:ROHMAX ADDITIVES GMBH
摘要:The present invention relates to a process for synthesis of polymer compositions with reduced catalyst content, wherein ethylenically unsaturated monomers containing less than 0.5 wt % of ethylenically unsaturated monomers with at least one carboxylic group, sulfonic acid group and/or at least one phosphonic acid group relative to the total weight of the ethylenically unsaturated monomers are polymerized by means of initiators containing a transferable group of atoms and of one or more catalysts comprising at least one transition metal in the presence of ligands which can form a coordination compound with the metal catalyst or catalysts and, after the polymerization, the catalyst contained in the polymer is at least partly separated. For this purpose, the polymer composition is filtered, after the polymerization, in the presence of at least one filter aid which contains at least 0.5 wt %, relative to the total weight of the filter aid, of repeating units that contain at least one carboxylic acid group, sulfonic acid group and/or at least one phosphonic acid group.

专利号:US-6610801-B1
优先权日:2000-11-13
标题:Processes for synthesis of polymer compositions
发明人:SCHERER MARKUS
权利人:ROHMAX ADDITIVES GMBH
摘要:The present invention relates to processes for synthesis of poly(meth)acrylate compositions, wherein ethylenically unsaturated monomers are transformed to polymers by means of initiators containing a transferable group of atoms and of one or more catalysts comprising at least one transition metal in the presence of ligands which can form a coordination compound with the metal catalyst or catalysts, wherein ethylenically unsaturated monomers containing 50 to 100 wt %, relative to the total weight of ethylenically unsaturated monomers, of (meth)acrylates of formula (I) are polymerizedwherein R denotes hydrogen or methyl, R1 denotes a straight-chain or branched alkyl group with 8 to 40, carbon atoms, R2 and R3 independently denote hydrogen or a group of the formula -COOR1, wherein R' denotes hydrogen or a straight-chain or branched alkyl group with 8 to 40, carbon atoms, in the presence of copper, the total concentration of copper of oxidation numbers (I) and (II) in the polymerization composition being <=200 ppm relative to the total weight of the composition.

专利号:US-6639029-B1
优先权日:2000-11-13
标 题 :Process for continuous synthesis of polymer compositions as well as use of same
发明人:SCHERER MARKUS; BOLLINGER JOSEPH MARTIN; COOPER JR DAVID J; TILLERY LARRY STEPHEN; WOODRUFF ROBERT
权利人:ROHMAX ADDITIVES GMBH
摘要:The present invention relates to a process for synthesis of polymer compositions, wherein ethylenically unsaturated monomers are polymerized by means of initiators containing a transferable atom or group of atoms and of one or more catalysts comprising at least one transition metal in the presence of ligands which can form a coordination compound with the metal catalyst or catalysts, the process being characterized in that the polymerization takes place by means of continuous process operation.

专利号:US-11717498-B2
优先权日:2013-12-31
标题 :Methods of treatment using amphetamine controlled release, prodrug, and abuse deterrent dosage forms
发明人:POPP KARL; MECKLER HAROLD
权利人:Chemapotheca LLC; PHARMAPOTHECA A INC
摘要:The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.

专利号:US-6906046-B2
优先权日:2000-12-22
标题 :Pharmaceutical uses and synthesis of benzobicyclooctanes
发明人:JACKSON RANDY W; DARWISH IHAB; BAUGHMAN TED A; HOWBERT J JEFFRY
权利人:CELLTECH R & D INC
摘要:Benzobicyclooctane compounds, their use in inhibiting cellular events involving TNF-α and IL-8, and in the treatment of inflammation events in general; a combinatorial library of diverse bicyclooctanes and process for their synthesis as a library and as individual compounds.
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合成参考文献


摘要:Kashemirov, B. A.; Błażewska, K.; Justyna, K.; Lyu, J.; McKenna, C. E., Science of Synthesis Knowledge Updates, (2021) 1, 400.
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