CAS: 7588-36-5; Methyl 2-(5-Methoxy-2-Methyl-1H-Indol-3-yl)Acetate
该化合物是属于非甲醚家族的化学化合物,其特点是与甲氧基和甲基组结合的无甲醇结构,该化合物通常具有与非甲醚衍生物相关的特性,例如潜在的生物活动和与各种受体的相互作用;经常研究其在植物生长条例中的作用,因为它可能模仿一种与生长和发育相关的关键植物激素Auxin;甲基酯功能组表示,它可能涉及酯化反应,影响其溶解性和再活性;就物理特性而言,由于存在缺水(聚醚)和水医学(箱状酸)成分,该化合物在室内温度上可能是一种固体或液体,具有中度极性;在处理和储存方面,应参考安全数据,如任何化学物质,以确保遵循适当的实验室做法.
- 英文名称Methyl 2-(5-Methoxy-2-Methyl-1H-Indol-3-yl)Acetate
- 中文名称5-甲氧基-2-甲基-1H-吲哚-3-乙酸甲酯
- IUPAC名称methyl 2-(5-methoxy-2-methyl-1H-indol-3-yl)acetate
- 其它别名5-甲氧基-2-甲基-1H-吲哚-3-乙酸甲酯; 5-甲氧基-2-甲基-3-吲哚乙酸甲酯; Methyl 5-Methoxy-2-Methyl-1H-Indole-3-Acetate
- CAS编号7588-36-5
- MFCD编号:MFCD00218549
- EINECS号:231-497-4
- 分子式:C13H15NO3分子量:233.26
- 产品CID: 1750902
- 产品分类有机原料→分子砌块→芳杂环类化合物→吲哚类化合物
物理性质
MSDS等安全信息
上下游产品
CAS号67-56-1 甲醇 | CAS号2882-15-7 5-甲氧基-2-甲基-3-吲哚乙酸 | CAS号624-45-3 乙酰丙酸甲酯 | CAS号19501-58-7 4-甲氧基苯肼盐酸盐 | CAS号75-36-5 乙酰氯 | CAS号53-86-1 吲哚美辛 | CAS号1076-74-0 5-甲氧基-2-甲基吲哚 | CAS号96-34-4 氯乙酸甲酯 | CAS号1601-19-0 2-(1-benzoyl-5-... | CAS号3285-40-3 5-甲氧基-2-甲基吲哚-3-乙酸苄酯 | CAS号1601-18-9 2-(1-(4-氯苯甲酰基)-... | CAS号16401-76-6 2-[5-methoxy-2-... | CAS号1568-31-6 2-[5-methoxy-1-... | CAS号64160-54-9 2-[5-methoxy-2-...合成工艺路线路线简述
- 合成目标产物 Methyl 5-Methoxy-2-Methyl-1H-Indole-3-Acetate 主要起始原料 Methanol And 5-Methoxy-2-Methyl-3-Indoleacetic Acid
- (文献来源)合成步骤主要原料 Methanol 和 5-Methoxy-2-Methyl-3-Indoleacetic Acid
📜吲哚美辛置于三甲基氯硅烷,Sodium Hydroxide体系中,用 水 作为反应溶剂,化学反应生成 5-甲氧基-2-甲基-3-吲哚乙酸甲酯
参考文献:Bifunctional Conjugates With Potent Inhibitory Activity Towards Cyclooxygenase And Histone Deacetylase
标题:Bifunctional Conjugates With Potent Inhibitory Activity Towards Cyclooxygenase And Histone Deacetylase
摘要:We Herein Disclose A Series Of Compounds With Potent Inhibitory Activities Towards Histone Deacetylases (Hdac) And Cyclooxygenases (Cox). These Compounds Potently Inhibited The Growth Of Cancer Cell Lines Consistent With Their Anti-Cox And Anti-Hdac Activities. While Compound 2B Showed Comparable Level Of Cox-2 Selectivity As Celecoxib,Compound Lib Outperformed Indomethacin In Terms Of Selectivity Towards Cox-2 Relative To Cox-1. An Important Observation With Our Lead Compounds (2B,8,11B,And 17B) Is Their Enhanced Cytotoxicity Towards Androgen Dependent Prostate Cancer Cell Line (Lncap) Relative To Androgen Independent Prostate Cancer Cell Line (Du-145). Interestingly,Compounds 2B And 17B Arrested The Cell Cycle Progression Of Lncap In The S-Phase,While Compound 8 Showed A G0/g1 Arrest,Similar To Saha. Relative To Saha,These Compounds Displayed Tumor-Selective Cytotoxicity As They Have Low Anti-Proliferative Activity Towards Healthy Cells (Vero); An Attribute That Makes Them Attractive Candidates For Drug Development. (C) 2016 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmc.2016.12.032
海关参考信息
- 2912110000-甲醛
2912120000-乙醛
2915110000-甲酸
2915211900-乙酸 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).
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