CAS: 630-10-4; Selenourea

上下游产品

CYANAMID S-methylthiouronium iodide diethyl ether water4-phenyl-5-phenylselenazol-2-ylamine 1,7-dihydro-purine-6-selone 2-selenazolin-4-one, amino form2-amino-Δ2-selenazolin-4-one, amino form 2-amino-4-phenyl-1,3-selenazole

📜氰胺置于phosphorus Selenide,水体系中,用 乙醇 作为反应溶剂,以37%的收率获得产物硒脲
参考文献:腈与磷 (V) 硒化物反应有效合成伯硒羧酸酰胺
标题:腈与磷 (V) 硒化物反应有效合成伯硒羧酸酰胺
摘要:在 Etoh/H2O 存在下,腈与 P 2 Se 5 的反应提供了多种伯硒羧酸酰胺.
DOI:10.1055/s-2002-35604

专利信息

专利号:US-2025049736-A1
优先权日:2021-12-16
标 题 :Sulfonamide derivatives and their use as soluble epoxide hydrolase inhibitors
发明人：IYER MALLIGA R; KUNDU BISWAJIT
权利人:THE US SECRETARY DEPARTMENT OF HEALTH
摘要:The present invention relates to compounds of formulae I and II. The compounds are useful for treating hypertension, atherosclerosis, pulmonary diseases, diabetes, pain, fibrosis, addictive disorders, inflammation, and immunological disorders or a condition treatable or preventable by inhibition of soluble epoxide hydrolase. Preferred compounds are N-((adamantan-1-yl)carbamoyl)-benzenesulfonamide derivatives. Exemplary compounds are e.g. •N—(((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)carbamoyl)-4-methylbenzenesulfonamide (example 14, compound 4a) •4-(tert-butyl)-N—(((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)carbamoyl)benzenesulfonamide (example 15, compound 4b) •N—(((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)carbamoyl)-4-(trifluoromethyl)benzenesulfonamide (example 16, compound 4j). The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof.