CAS: 61278-21-5; (S)-3-Aminopropane-1,2-Diol

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616-30-8 66211-46-9 137618-48-5

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CAS号616-30-8 3-氨基-1,2-丙二醇 | CAS号82954-65-2 (S)-(2,2-二甲基-1,... | CAS号57044-25-4 (|R|)-(+)-缩水甘油 | CAS号85820-82-2 2,2-二甲基-4(s)-4-... | CAS号41274-09-3 (R)-对甲苯磺酸-1-甘油酯 | CAS号123356-17-2 (S)-3-(benzylox... | CAS号7517-99-9 5-羟甲基噁唑烷-2-酮

(2S)-2-Hydroxy-3-Phenylmethoxypropanenitrile 反应生成 (S)-3-氨基-1,2-丙二醇
参考文献:Lipase-Catalyzed Irreversible Transesterification Using Enol Esters: Resolution Of Cyanohydrins And Syntheses Of Ethyl (R)-2-Hydroxy-4-Phenylbutyrate And (S)-Propranolol
标题:Lipase-Catalyzed Irreversible Transesterification Using Enol Esters: Resolution Of Cyanohydrins And Syntheses Of Ethyl (R)-2-Hydroxy-4-Phenylbutyrate And (S)-Propranolol
摘要:
DOI:10.1016/s0040-4039(00)99613-8

专利信息

专利号:US-12240835-B2
优先权日:2018-09-18
标题:Substituted benzamides as intermediates in the synthesis of inhibitors of tyrosine kinase enzymatic activity
发明人：ROMERO F ANTHONY; KIRSCHBERG THORSTEN A; HALCOMB RANDALL; XU YINGZI
权利人:TERNS PHARMACEUTICALS INC
摘要:Provided herein are compounds, preferably compounds inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, compositions thereof, and methods of their preparation, and methods of inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, and methods for treating diseases wherein modulation of BCR-ABL1 activity prevents, inhibits, or ameliorates the pathology and/or symptomology of the disease. Intermediates such as compounds of Formula (S23), which are useful in the synthesis of compounds inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, are also provided.

专利号:US-2024325572-A1
优先权日:2021-07-15
标 题 :N-heterocyclyl substituted 2-cyano-3-(naphthalen-2-yl)acrylamide derivatives as fluorophors for detection of amyloid and amyloid-like proteins for diagnosis of neurodegenerative disorders
发明人：SARRAF STELLA T
权利人:AMYDIS INC
摘要:Provided herein is the design and synthesis of novel molecular rotor fluorophores of formula I useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are the compounds for use in methods for diagnosis and treatment of diseases associated with an amyloid or amyloid like proteins, such as e.g. Alzheimer's disease or traumatic brain injury (TBI), Parkinson's disease, vascular dementia, amyotrophic lateral sclerosis, Down syndrome, traumatic brain injury, chronic traumatic encephalopathy, schizophrenia or depression. Exemplary compounds are e.g. N-heterocyclyl substituted 2-cyano-3-(naphthalen-2-yl)acrylamide derivatives, such as e.g. (E)-2-cyano-N-(2-(2-hydroxy)ethoxy)ethyl)-3-(6-(pyrrolidin-1-yl)naphthalen-2-yl) acrylamide (example 1): Experimental data on in-vitro binding studies with amyloid beta is provided.

专利号:US-9382194-B2
优先权日:2011-10-31
标 题:Iodination process for the preparation of 3, 5-disubstituted-2, 4, 6-triiodo aromatic amines compounds
发明人：XING HONGDENG; LI LEI; HU ZHIQI
权利人:XING HONGDENG; LI LEI; HU ZHIQI; IMAX DIAGNOSTIC IMAGING HOLDING LTD
摘要:The invention discloses a improved process for the preparation of 3,5-disubstituted-2,4,6-triiodo aromatic amines of formula (II), wherein R 1 and R 2 are defined as herein. The compounds of formula (II) are the key intermediates for the synthesis of a series of non-ionic contrast agents such as Iopamidol, Iohexol and Iodixanol. The process comprises reacting chlorine-free iodinating reagents with 3,5-disubstituted-2,4,6-triiodo aromatic amines to obtain 3,5-disubstituted-2,4,6-triiodo aromatic amines of formula (II), wherein the molar yield of the iodination reaction can reach to 89%.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-2014094605-A1
优先权日:2008-12-11
标 题 :Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates

专利号:JP-6130891-B2
优先权日:2008-12-11
标 题 :Synthesis of carbamoylpyridone HIV integrase inhibitors and their intermediates