CAS: 56970-78-6; 3-Bromo-2-Methylpropanoic Acid

上下游产品

poly(methacrylic acid) 3-bromo-2-methyl-propionic acid methyl ester poly(methacrylic acid) 2-methyl-3-sulfanylpropanoic acid 3-bromo-2-methylpropanoyl chloride S-(2-D,L-carboxy-n-propyl)-L-cysteine

📜甲基丙烯酸置于氢溴酸体系中,化学反应生成 2-甲基-3-溴丙酸
参考文献:卡托普利的改良合成方法.
标题:卡托普利的改良合成方法.
摘要:描述了使用甲基丙烯酸作为起始原料改进的卡托普利合成.用卤化氢处理甲基丙烯酸(i),得到3-卤代-2-甲基丙酸ii和iii,用亚硫酰氯处理得到相应的3-卤代-2-甲基丙酰氯iv和v.iv或v与l-脯氨酸一起产生n-(r,S-3-卤代-2-甲基丙酰基)-L-脯氨酸vi和vii,使用二环己胺将其分离成光学纯的r-和s-非对映异构体.用甲醇硫化氢铵处理vi或vii的卤化物得到卡托普利,收率为28%.
DOI:10.1002/jps.2600731251

专利信息

专利号:US-8178712-B2
优先权日:2006-06-23
标 题:Process for the synthesis of Ibandronate sodium
发明人：RAO DHARAMARAJ RAMCHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI GANPATI
权利人:RAO DHARAMARAJ RAMCHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI GANPATI; CIPLA LTD
摘要:The present invention relates to an improved process for the synthesis of Ibandronate sodium of formula (I). The present invention also provides novel processes for the synthesis of 3-[N-(methylpentyl)amino]propionic acid (III).

专利号:WO-2024064836-A1
优先权日:2022-09-21
标 题:Molecularly engineered brush-like graft copolymers and compositions and methods thereof
发明人：DASHITIMOGHADAM ERFAN; KEITH ANDREW; VARNOSFADERANI MOHAMMAD V; SHEIKO SERGEI; MAW MITCHELL
权利人:UNIV NORTH CAROLINA CHAPEL HILL; DASHITIMOGHADAM ERFAN; KEITH ANDREW; VARNOSFADERANI MOHAMMAD V
摘要:The subject matter described herein is directed to molecularly engineered brush-like graft copolymer elastomers and applications thereof. The developed formulation platform is based on the synthesis of brush-like graft copolymer networks with engineered macromolecular architecture composed of brush-like polymers, such as combs and bottlebrush polymers, and block copolymers composed of combinations of brush and linear blocks, with capability of bearing desired chemical functionalities, for example, brush side-chains, chain-ends, and/or brush backbone.

专利号:US-9441177-B2
优先权日:2011-05-09
标题:Lubrication with oil-compatible polymer brushes
发明人：BIELECKI ROBERT M; BENETTI EDMONDO M; SPENCER NICHOLAS D
权利人:BIELECKI ROBERT M; BENETTI EDMONDO M; SPENCER NICHOLAS D; SWATCH GROUP RES & DEV LTD
摘要:A polymer-brush-based, surface-modification strategy for friction and wear reduction in hard contact under boundary-lubrication conditions is proposed, specifically for a non-aqueous environment. Surface-initiated Atom Transfer Radical Polymerization (SI-ATRP) was employed for the synthesis of three different oil-compatible, hydrophobic polymer brushes based on alkyl methacrylates. This study presents polymerization kinetics, chemical characterization by means of Fourier transform infrared spectroscopy (FTIR) and surface morphologies observed in atomic force microscopy (AFM). The lubrication properties of the anchored polymers were evaluated macroscopically by means of ball-on-disk methods and on the nanonewton scale by lateral force microscopy (AFM/LFM) and showed significant reduction in friction up to contact pressures as high as 460 MPa. The frictional response of surface-grafted polymers is shown to depend strongly on the compatibility of the polymer with the chosen lubricating fluid. Their good tribological performances have also been proven with watchmaking lubricants. These results do make the prevent invention a suitable candidate for a watchmaking application (such as at the balance pivot or the escapement) in order to increase the efficiency and reliability of the movements.

专利号:US-9765169-B2
优先权日:2013-04-18
标题 :Functionalized polymer hybrids
发明人：DAS SUBHA RANJAN; AVERICK SAADYAH; DEY SOURAV K; MATYJASZEWSKI KRZYSZTOF
权利人:UNIV CARNEGIE MELLON
摘要:A method of synthesizing a polynucleotide composition includes attaching a compound including at least one initiator or at least one transfer agent for a reversible deactivation radical polymerization to an end of a nucleotide chain assembly immobilized upon a solid phase support during a solid phase synthesis of a polynucleotide so that the initiator or the transfer agent is attacked to the end of a nucleotide chain assembly in a manner which is stable under conditions of deprotection of the polynucleotide, and growing a polymer from the initiator of from a site of the chain transfer agent via the reversible deactivation radical polymerization to form the polynucleotide composition.

专利号:EP-2038291-B1
优先权日:2006-06-23
标 题:Process for the synthesis of ibandronate sodium

专利号:EP-2038291-A2
优先权日:2006-06-23
标 题:Process for the synthesis of ibandronate sodium