CAS: 5399-44-0; 3-Methyl-1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine

相似化合物

2380-63-4 15937-69-6 1812857-11-6

上下游产品

5-amino-3-methyl-1H-pyrazole-4-carbonitrile formamide (1-ethoxyethylidene)malononitrile acetylmalonodinitrile 1-((8-chloro-2-(2-(trifluoromethyl)phenyl)-quinolin-3-yl)methyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 1-((5-chloro-2-(2-(trifluoromethyl)phenyl)quinolin-3-yl)-methyl)-3-methyl-1H-pyrazolo [3,4-d]pyrimidin-4-amine 1-((2-(2-chlorophenyl)-8-methylquinolin-3-yl)methyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 1-(1-(8-chloro-2-(3-fluorophenyl)-quinolin-3-yl)ethyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

📜2-(1-甲氧基亚乙基)丙二腈置于三乙胺体系中,化学反应生成 3-甲基-1H-吡唑并[3,4-D]嘧啶-4-胺
参考文献:1,3-二取代-4-氨基吡唑并[3,4-D]嘧啶,一类新型的磷脂酶d抑制剂
标题:1,3-二取代-4-氨基吡唑并[3,4-D]嘧啶,一类新型的磷脂酶d抑制剂
摘要:磷脂酶d酶裂解脂质底物以产生磷脂酸,磷脂酸是许多必需细胞分子的重要前体.磷脂酶d是调节癌细胞侵袭性的靶标.这项研究报告了基于1,3-二取代-4-氨基-吡唑并嘧啶核心结构的新型磷脂酶d抑制剂的合成.这些分子被合成并用于为纯化的细菌磷脂酶d的抑制,这是高度同源的人的pld执行初步筛选1.最初用细菌磷脂酶d酶进行测试,然后用重组人pld 1和pld 2酶确认,此处显示的分子表现出对磷脂酶d活性的抑制作用(ic 50)在低纳摩尔至低微摩尔范围内,同时具有单体底物dic 4 Pc和磷脂囊泡和胶束.数据强烈表明这些抑制分子直接阻断了酶/囊泡底物的结合.初步活性研究使用重组人磷脂酶ds在体内细胞测定中测量了转磷脂酰化和头部裂解,表明在生理环境中这些有效的抑制性新分子在中低纳摩尔范围内具有抑制作用.
DOI:10.1111/cbdd.12319

专利信息

专利号:WO-2022216900-A2
优先权日:2021-04-09
标题 :Synthesis of rapamycin analog compounds

专利号:US-11020399-B2
优先权日:2011-05-04
标 题:Intermediates useful in the synthesis of compounds as modulators of protein kinases

专利号:WO-2023109870-A1
优先权日:2021-12-15
标 题:Pyrazolopyrimidine compound and use thereof
发明人：YE BIN
权利人:SHANGHAI YIDI BIOTECHNOLOGY CO LTD
摘要:The present invention belongs to the field of drug synthesis, provides a pyrazolopyrimidine compound and the use thereof, and specifically relates to a pyrazolopyrimidine compound as shown in formula (I) and/or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the compound and/or the pharmaceutically acceptable salt thereof, a method for preparing the compound, and the use of the compound in the preparation of a drug for treating related diseases mediated by PI3K.