CAS: 53985-49-2; 3-Chloro-5-(Trifluoromethyl)Benzoic Acid

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CAS号886496-83-9 3-氯-5-(三氟甲基)苯甲酰氯

3-三氟甲基苯甲酸置于palladium 10% On Activated Carbon 亚硝酸特丁酯,硫酸,氢气,硝酸,Copper(L) Chloride体系中,用 乙醇,乙腈 作为反应溶剂,50.0 °C,101.33 Kpa 条件下,反应 11.67H,反应生成 3-氯-5-三氟甲基苯甲酸
参考文献:Piperidine Derivative And Use Thereof
标题:Piperidine Derivative And Use Thereof
摘要:本发明提供了一种新颖的哌啶衍生物和含有该衍生物的催吐肽受体拮抗剂,以及由下式表示的化合物: 其中r1为羰胺甲基,甲磺酰乙基羰基等;r2为甲基或环丙基;r3为氢原子或甲基;r4为氯原子或三氟甲基;r5为氯原子或三氟甲基;以及由下式表示的基团: 是由下式表示的基团: 其中r6为氢原子,甲基,乙基或异丙基;r7为氢原子,甲基或氯原子;r8为氢原子,氟原子,氯原子或甲基;或3-甲基噻吩-2-基,并且其盐.

专利信息

专利号:US-9782406-B2
优先权日:2011-10-25
标 题 :Kinase inhibitor and method for treatment of related diseases
发明人：PAN ZHENGYING; LI XITAO
权利人:UNIV PEKING SHENZHEN GRADUATE SCHOOL; BEIJING RECIPROCAPHARMACEUTICALS CO LTD; BEIJING RECIPROCAPHARMACEUTICALS CO LTD
摘要:Disclosed is a compound of (aminophenylamino) pyrimidyl benzamides and a synthesis method thereof. The compound has Btk-inhibition activity and can be used to treat autoimmune diseases, heteroimmune diseases, cancers or thromboembolic diseases.

专利号:US-9150522-B2
优先权日:2011-10-25
标 题:Kinase inhibitor and method for treatment of related diseases
发明人：PAN ZHENGYING; LI XITAO
权利人:UNIV PEKING SHENZHEN GRAD SCHO; BEIJING RECIPROCAPHARMACEUTICALS CO LTD
摘要:Disclosed is a compound of (aminophenylamino) pyrimidyl benzamides and a synthesis method thereof. The compound has Btk-inhibition activity and can be used to treat autoimmune diseases, heteroimmune diseases, cancers or thromboembolic diseases.