CAS: 47747-56-8; Talampicillin

上下游产品

3-Bromophthalide R)-2-(2-methoxycarbonyl-1-methyl-vinylamino)-2-phenyl-acetylamino]-penicillanic acid; potassium salt6β-[(R)-2-(2-methoxycarbonyl-1-methyl-vinylamino)-2-phenyl-acetylamino]-penicillanic acid; potassium salt R)-2-benzylideneamino-2-phenyl-acetylamino)-penicillanic acid (Ξ)-3-oxo-1,3-dihydro-isobenzofuran-1-yl ester6β-((R)-2-benzylideneamino-2-phenyl-acetylamino)-penicillanic acid (Ξ)-3-oxo-1,3-dihydro-isobenzofuran-1-yl ester d(-)-alpha-phenylglycine chloride hydr°Chloride

📜Penicillin G Potassium置于potassium Hydrogencarbonate体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 5.0H,反应生成 酞氨西林
参考文献:氨苄青霉素的乳酸酯.
标题:氨苄青霉素的乳酸酯.
摘要:几种d-α-氨基苄青霉素盐酸盐的乳醇酯(va-E)是通过相应的苄青霉素(iia-E)乳醇酯或d-α-氨基苄青霉素(氨苄青霉素)合成的.乳醇酯iia-E是采用苄青霉素钾盐(i)和某些乳醇的卤化物制备的.在这些化合物中,由于乳醇部分的c5'位,两个2(5H)-呋喃酮-5-基苄青霉酸盐(iib)的异构体能够很容易地从立体异构体的混合物中分离出来.我们发现,在口服给药后,这些氨苄青霉素盐酸盐的乳醇酯(va-E)在大鼠体内的血药浓度均高于氨苄青霉素本身,特别是va和ve表现得更为优越.
DOI:10.1248/cpb.24.102

专利信息

专利号:US-2007203079-A1
优先权日:2005-11-21
标题:Methods of using small molecule compounds for neuroprotection
发明人：CALDWELL GUY A; CALDWELL KIM A; CAO SONGSONG
权利人:CALDWELL GUY A; CALDWELL KIM A; CAO SONGSONG
摘要:Methods are provided for preventing neurodegeneration and neuronal loss by administering compositions comprising small molecule compounds with the effect of preventing neurodegeneration and neuronal loss. In one aspect of the invention, the methods and compositions are also useful for treating neurodegenerative diseases. Small molecule compounds provide an important treatment option because of their stability, ease of use in both manufacture and formulation, ease of administration, and patient compliance. The small molecule compound compositions of the present invention may include topoisomerase II inhibitors, bacterial transpeptidase inhibitors, calcium channel antagonists, cyclooxygenase inhibitors, folic acid synthesis inhibitors, or sodium channel blockers and functional analogues thereof that have an effect on neurodegeneration. The compositions of the present invention may be administered prophylactically before the onset of clinical symptoms or after clinical symptoms of a neurodegenerative disease have manifested.

专利号:WO-2009056955-A1
优先权日:2007-10-30
标题 :Amine-bearing phospholipids (abps), their synthesis and use
发明人：ZUMBUEHL ANDREAS
权利人:UNIV BASEL; ZUMBUEHL ANDREAS
摘要:Disclosed herein are amine-bearing phospholipids (ABP). The ABPs display many properties and functionalities of naturally occurring phospholipids, but also new properties and functionalities, such as the ability to polymerize while maintaining structural integrity, that may supplement or expand the functionalities of naturally occurring phospholipids.

专利号:US-2025002508-A1
优先权日:2020-05-05
标题 :Boronic acid derivatives and synthesis, polymorphic forms, and therapeutic uses thereof
发明人：HECKER SCOTT J; BOYER SERGE HENRI; BIO MATTHEW M; FANG YUANQING; GONZALES DE CASTRO ANGELA; LEFORT LAURENT; ZHU ZUOLIN; LINDER THOMAS
权利人:QPEX BIOPHARMA INC
摘要:Disclosed herein are antimicrobial compounds, polymorphic forms, compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs).

专利号:US-4439363-A
优先权日:1979-06-20
标题:Acetylmethyl ester of hetacyllin and/or salts of this ester
发明人：GRUSZECKI WOJCIECH A; BUSKO-OSZCZOPOWICZ IRENA M; GDULEWICZ-GRUSZECKA MARIA; CIESLAK JERZY J; BOROWSKI EDWARD; GUMIEZNA TERESA
权利人:POLITECHNIKA GDANSKA; INST PRZEMYSLU FARMACEUTYOZNEG
摘要:The acetylmethyl ester of hetacyllin and/or its salts of an organic or inorganic acid are described and methods for their synthesis wherein a tertiary amine and chloroacetone are introduced to hetacyllin in an organic solvent or chloroacetone is introduced to hetacyllin in the form of a salt with an alkali metal in an organic solvent, and then from the reaction mixture, the acetylmethyl ester of hetacyllin is isolated in free form and, if desired, a salt of the ester is obtained by reaction with an organic or inorganic acid in an organic solvent. n As tertiary amines, trialkylamine, N-methylpiperidine, N-ethylpiperidine or N-methylmorpholine are used; as organic solvents in obtaining the ester, dimethylformamide, dimethylacetamide or dimethylsulfoxide are used. In obtaining salts of the ester the organic solvents used are aliphatic alcohols of a chain length C 2 -C 5 ; ketones, preferably acetone; ethers, such as diethyl, dipropyl, diisopropyl, dibutyl ethers, or their mixtures. n The obtained compounds show an antibacterial action like ampicillin but after administration per os they show a considerably higher level of the antibiotic than that after administration of free ampicillin or its esters.

专利号:US-4072677-A
优先权日:1975-12-13
标题 :Penicillin synthesis
发明人：CALLANDER SIDNEY EDWARD
权利人:BEECHAM GROUP LTD
摘要:Process of preparing phthalidyl ampicillin or other orally absorbable penicillin ester by esterification of the parent penicillin in a two-phase system using a phase transfer catalyst which increases the solubility of a salt form of the penicillin in the water-immiscible solvent used in the process. The phase transfer catalysts are quaternary ammonium salts or tertiary amines of non-low molecular weight, or crown ethers.

专利号:US-4452796-A
优先权日:1982-06-14
标题:6-Aminoalkylpenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
发明人：BARTH WAYNE E
权利人:PFIZER
摘要:Beta-lactamase inhibitors which are 6-alpha- and 6-beta-(aminomethyl) and (1-aminoethyl)pencillanic acid 1,1-dioxides; pharmaceutically-acceptable salts thereof; conventional esters thereof which are hydrolyzable in vivo; bis-methanediol esters thereof; or mixed methanediol esters with said beta-lactamase inhibitors and sulbactam. Pharmaceutical compositions comprising said beta-lactamase inhibitors and a conventional beta-lactam antibiotic, used in the treatment of bacterial infections. Compounds useful as intermediates in the synthesis of said beta-lactamase inhibitors. Antibacterial mixed bis-methanediol esters of said aminoalkyl penicillanic acid 1,1-dioxides and ampicillin or amoxicillin, also used in the treatment of bacterial infections; and intermediates therefor.