CAS: 4429-63-4; Methyl (3Ar,3A1S,10Br)-3A-Ethyl-3A,3A1,4,6,11,12-Hexahydro-1H-Indolizino[8,1-Cd]Carbazole-5-Carboxylate

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CAS号55856-70-7 19-Iodo-tabersonine | CAS号17640-15-2 氰基甲酸甲酯 | CAS号32975-46-5 (3aR,10bR)-3aα-... | CAS号41787-54-6 16-epi-19-S-vin... | CAS号80642-07-5 5-(chloromethyl... | CAS号66859-22-1 1,2,3,4,5,6-Hex... | CAS号536-78-7 3-乙基吡啶 | CAS号23995-13-3 1-methyl-carbaz... | CAS号120202-64-4 Ervayunine

2-甲基吲哚-3-甲醛置于咪唑,盐酸,Titanium(Iv) Tetraethanolate,Potassium Tert-Butylate,Sodium Hydride,亚甲基三苯基膦烷,Lithium Hexamethyldisilazane,Lithium Diisopropyl Amide体系中,用 四氢呋喃,水,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 24.0H,反应生成 它勃宁
参考文献:芳烃融合的米歇尔.迈克尔/曼尼希反应的发展和范围:在孢霉属生物碱(-)-曲霉精,(-)-他布森碱和(-)-长春花碱的总合成中的应用
标题:芳烃融合的米歇尔.迈克尔/曼尼希反应的发展和范围:在孢霉属生物碱(-)-曲霉精,(-)-他布森碱和(-)-长春花碱的总合成中的应用
摘要:描述了芳烃融合的多米诺骨牌迈克尔/曼尼希路线的开发和应用,将其与曲霉生物碱的四氢咔唑(abe)核心结合使用.就亲核组分(即,N-亚磺酰基金属亚胺)和亲电组分(即,迈克尔受体)研究了该新型转化的范围.还讨论了该方法在10-11个步骤中分别分别成功合成简明的吲哚生物碱(-)-Aspidospermidine,(-)-Tabersonine和(-)-Vincadifformine的简明总合成方法.
DOI:10.1021/acs.Joc.6B02551

专利信息

专利号:US-2025092433-A1
优先权日:2023-09-20
标 题:Polypeptides for use in the synthesis of kratom alkaloids
发明人：CASARETTO JOSE; AKTAR TARIQ A; ROTHSTEIN STEVEN; SOUBEYRAND ERIC
权利人:MITRADYNE CORP
摘要:Described herein are polypeptides encoding enzymes for the synthesis of monoterpene indole alkaloids. For example, the polypeptide comprises or consists of the sequence of SEQ ID NO: 1-68, or a variant thereof having at least 80% sequence identity to SEQ ID NO: 1-68, or a fragment of the polypeptide, or the variant thereof.

专利号:US-4400249-A
优先权日:1980-09-30
标 题:Partial synthesis process for preparing (+) -vincamine and related indolic alkaloids
发明人：BENARDELLI GIOVANNI
权利人:LINNEA SA
摘要:A process of partial synthesis of vincamine and related indolic alkaloids for use as the active principal ingredient in drugs for treatment of diseases of the circulatory system and the central nervous system. The process includes the technique of activating oxygen in the elementary state in situ into an excited singlet state for chemical reaction by subjecting a reaction mixture to gaseous oxygen blowing under substantially ambient temperature and pressure conditions while effecting irradiation of the mixture by a light source. Operating conditions of the partial synthesis process are simplified, treatment times are reduced, and conversion yields are high.

专利号:US-2025304985-A1
优先权日:2022-04-08
标题 :Genetically Engineered Plants for Increased Production of Vindoline
发明人：LEE-PARSONS CAROLYN; COLE LAUREN F
权利人:UNIV NORTHEASTERN
摘要:Two novel transcription factors, CrDELLA1 and CrDELLA2, are described in Catharanthus roseus plants. The DELLA transcription factors have a regulatory role in the synthesis of vinblastine and vincristine, two important anti-cancer compounds that have proved difficult to obtain in sufficient quantities. The present technology provides genetically modified C. roseus plants having enhanced DELLA activity, which leads to activation of multiple enzymes in the biosynthetic pathway leading to vinblastine and vincristine. The genetic modifications can be used together with activation of plant defense mechanisms and responses to light in order to boost vinblastine and vincristine synthesis.

专利号:US-4316029-A
优先权日:1979-06-22
标 题:Synthesis of vincaminic acid derivatives
发明人：ROSSEY GUY
权利人:SYNTHELABO
摘要:Vincaminic acid derivatives of formula (A) ##STR1## useful in treating cerebral insufficiency, are prepared by reacting 1-ethyl-2,3,4,6,7,12-hexahydroindolo[2,3-a]quinolizine with the 2,4-DNP hydrazone of ethyl or methyl bromopyruvate followed by (i) reduction of the Câ•?N bond and (ii) simultaneous cyclization with removal of the ketone-protecting group in either order.

专利号:US-11072613-B2
优先权日:2016-03-02
标 题:Compositions and methods for making terpenoid indole alkaloids
发明人：DE LUCA VINCENZO; QU YANG
权利人:WILLOW BIOSCIENCES INC
摘要:Methods that may be used for the manufacture of a class of chemical compounds known as terpenoid indole alkaloids, including tabersonine and catharanthine are provided. Compositions useful for the synthesis of terpenoid indole alkaloids, including tabersonine and catharanthine are also provided. The provided compounds are useful in the manufacture of chemotherapeutic agents.

专利号:EP-4538367-A2
优先权日:2023-09-20
标 题:Polypeptides for use in the synthesis of kratom alkaloids