CAS: 32797-61-8; 4-(Aminomethyl)Benzene-1-Carboximidamide

上下游产品

CAS号328552-93-8 4-氨基甲基-N-羟基苯甲脒 | CAS号84466-87-5 4-Cyanobenzyl a... | CAS号10406-25-4 4-氰基苯甲胺 | CAS号17201-43-3 α-溴对甲基苯甲腈 | CAS号63914-51-2 [(4-cyanophenyl...

📜4-(叠氮甲基)苯甲腈置于palladium On Activated Charcoal 盐酸,氨,氢气体系中,用 甲醇,氯仿 作为反应溶剂,化学反应生成 4-氨甲基苄眯二盐酸盐
参考文献:Design,Synthesis,And Evaluation Of Oxyanion-Hole Selective Inhibitor Substituents For The S1 Subsite Of Factor Xa
标题:Design,Synthesis,And Evaluation Of Oxyanion-Hole Selective Inhibitor Substituents For The S1 Subsite Of Factor Xa
摘要:We Have Designed,Synthesized,And Evaluated The Factor Xa Inhibitory Activities Of P-Amidinophenyl-Sulfones,Amines,And Alcohols Intended To Take Advantage Of The Polarity And Hydrogen-Bonding Potential Of The Oxyanion Hole Region Of The S1 Specificity Pocket. We Demonstrate That Placement Of An Anionic Group Within The Oxyanion Bole Region Of The Catalytic Site Substantially Enhances Activity,With Small Flexible Groups Favored Over Bulkier Ones. Ab Initio Pk(A) Calculations Suggest That The Hydroxyl Substituent Frequently Used For Benzamidine Moieties May Be Ionized To Form An Anionic Group,Consistent With The General Trend. One Nonamidine Based Substituent Also Shows Promising Activity. (C) 2004 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2004.07.054

专利信息

专利号:US-2023160000-A1
优先权日:2015-09-28
标 题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

专利号:US-2023028388-A1
优先权日:2015-09-28
标 题 :Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

专利号:US-11085076-B2
优先权日:2015-09-28
标 题 :Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis

专利号:US-5939392-A
优先权日:1993-06-03
标 题 :Method of thrombin inhibition
发明人：ANTONSSON KARL THOMAS; BYLUND RUTH ELVY; GUSTAFSSON NILS DAVID; NILSSON NILS OLOV INGEMAR
权利人:ASTRA AB
摘要:The invention relates to new competitive tripeptide inhibitors of trypsin-like serine proteases, their synthesis, pharmaceutical compositions containing the compounds as active ingredients, and the use of the compounds as thrombin inhibitors, anticoagulants and antiinflammatory inhibitors for prophylaxis and treatment of related diseases.

专利号:US-2009215080-A1
优先权日:2005-10-13
标题:Methods for identification of inhibitors of enzyme activity
发明人：SINHA SUKANTO; CHILCOTE TAMIE JO
权利人:ACTIVESITE PHARMACEUTICALS
摘要:The invention discloses compositions and methods of synthesis to create novel ligands and drugs and identifying such compounds as inhibitors of enzyme targets for use in the treatment of clinical disorders, including cancer, infectious diseases, parasitic infestations, neurological disorders, reproductive disorders, inflammatory disorders, circulatory disorders, and metabolic disorders.

专利号:US-5723444-A
优先权日:1993-06-03
标 题:Starting materials in the synthesis of thrombin and kinogenase inhibitors