CAS: 23602-78-0; Benfluorex Hydrochloride

该化合物是一种合成化合物,主要以其作为抗毒剂药物和食欲抑制剂而闻名,属于被称为氟化胺的药物类别,在结构上与苯丙胺有关;Benfluorex作为血清素受体激动剂,影响大脑中的...

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CAS号1886-26-6 Phenethylamine,... | CAS号31173-14-5 2-[[1-methyl-2-... | CAS号98-88-4 苯甲酰氯

合成工艺路线路线简述

    📜去甲氟苯丙胺 反应生成苯氟雷司
    参考文献:Fr1517587
    标题:Fr1517587

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    专利信息


    专利号:US-10925977-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
    发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
    权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
    摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

    专利号:US-6787668-B2
    优先权日:2000-04-13
    标 题 :2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
    发明人:PITZELE BARNETT S; SIKORSKI JAMES A; WEBBER RONALD KEITH
    权利人:PHARMACIA CORP
    摘要:The present invention is directed to a compound of formula I:or a pharmaceutically acceptable salt thereof, wherein:R1 is selected from the group consisting of H and methyl; andR2 is selected from the group consisting of H and methyl.The compounds possess useful nitric oxide synthetase inhibiting activity, and are expected to be useful in the treatment or prophylaxis of a disease or condition in which the synthesis or over synthesis of nitric oxide forms a contributory part.

    专利号:US-2024299311-A1
    优先权日:2022-04-05
    标题 :Ionizable cationic lipids and lipid nanoparticles
    发明人:KARMALI PRIYA PRAKASH; TANIS STEVEN
    权利人:KARMALI PRIYA PRAKASH; TANIS STEVEN; CAPSTAN THERAPEUTICS INC
    摘要:Ionizable cationic lipids, methods for synthesizing them, as well as intermediates useful in synthesis of these lipids and methods of synthesizing the intermediates are disclosed. The ionizable cationic lipids are useful as a component of lipid nanoparticles (LNP), which in turn can be used for the delivery of nucleic acids into cells in vivo or ex vivo. LNP compositions are also disclosed, including LNP comprising a functionalized lipid to enable conjugation of a binding moiety, and targeted LNP (tLNP), that is a LNP in which a binding moiety has been conjugated to the functionalized lipid and can serve as a targeting moiety to direct the tLNP to a desired tissue or cell type.

    专利号:KR-101513003-B1
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy compositions and applications

    专利号:US-10814013-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:AU-2007308022-A2
    优先权日:2006-10-05
    标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: McGee M, Whitehead N, Martin J, Collins N. Drug-associated pulmonary arterial hypertension. Clin Toxicol (Phila). 2018 Mar
    6:1-9. doi: 10.1080/15563650.2018.1447119. [Epub ahead of print] doi: 10.1007/s10695-018-0470-8. Epub 2018 Jan 19. doi: 10.1016/j.toxlet.2017.12.027. Epub 2018 Jan 4.
    5: Wang SL, Dong WB, Dong XL, Zhu WM, Wang FF, Han F, Yan X. Comparison of twelve single-drug regimens for the treatment of type 2 diabetes mellitus. Oncotarget. 2017 Aug 16;8(42):72700-72713. doi: 10.18632/oncotarget.20282. eCollection 2017 Sep 22.

    合成参考文献


    摘要:Astellas' lawsuit against Prescrire: French court rules that prescrire did not "denigrate" protopic (tacrolimus). Prescrire Int. 2011 Jul;20(118):191.
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