CAS: 220899-03-6; (3-Bromo-6-Methoxy-2-Methylphenyl)(2,3,4-Trimethoxy-6-Methylphenyl)Methanone

该化合物是一种化学化合物,被归类为杀真菌剂,主要用于农业用途,以控制作物中各种真菌病;它属于被称为苯丙烯的化合物类别,并展示一种独特的行动方式,干扰真菌细胞过程,使其对诸如温素和粉状温素等病原体有效;Metrafenone的特征是它对非目标生物的毒性相对较低,与一些传统的杀真菌剂相比,它是一种更环保的选择;它通常作为一种花生喷雾使用,因其系统特性而为人所知,允许植物吸收它,并随着时间的推移提供保护;此外,Metrafenone具有有利的环境特征,在土壤和水中持久性较低,降低了污染风险;它的效力,加上对有益生物的较低风险,将Metrafenone作为农业虫害综合管理战略的宝贵工具.

结构式图片

相似化合物

252955-10-5 3046154-65-5 1094749-23-1

欧盟法规

[欧盟农药活性物质

上下游产品

CAS号6443-69-2 3,4,5-三甲氧基甲苯 | CAS号712273-62-6 5-bromo-2-metho... | CAS号15219-34-8 草酰溴 | CAS号6520-83-8 2-甲氧基-6-甲基苯甲酸乙酯

合成工艺路线路线简述

    3,4,5-三甲氧基甲苯,5-Bromo-2-Methoxy-6-Methyl-Benzoic Acid Chloride置于iron(III) Chloride体系中,用 氯苯 用作溶剂,化学反应 6.0H,以97.4%的收率获得苯菌酮
    参考文献:[de] Verfahren Zur Herstellung Von Benzophenonen Method For The Production Of Benzophenones[fr] Procede Pour Produire Des Benzophenones
    标题:[de] Verfahren Zur Herstellung Von Benzophenonen Method For The Production Of Benzophenones[fr] Procede Pour Produire Des Benzophenones
    摘要:制备化合物i的方法,其中化合物i的结构如下(化学式1),其中x代表氯,羟基,甲氧基或c1-C6-烷基羰基氧基,Y代表氯或溴,通过将化合物ii的酸氯化物(化学式2)与3,4,5-三甲氧基甲苯反应而得.该方法的特点在于,在以下条件下进行反应:A)在以下溶剂的存在下进行反应,所述溶剂选自以下组合:氯苯,三氟甲基苯和硝基苯;B)相对于酸氯化物,加入0.01至0.2摩尔%的铁催化剂;C)在温度在60oc和所述溶剂的沸点之间的范围内进行反应.

    海关参考信息

    专利信息


    专利号:WO-2025056767-A1
    优先权日:2023-09-15
    标题 :Process for the preparation of enantiomerically enriched aliphatic amines
    发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

    专利号:US-6441219-B1
    优先权日:1999-07-15
    标 题 :Process for the preparation of 5-and/or 6-substituted-2-hydroxybenzoic acid esters
    发明人:DOEHNER JR ROBERT FRANCIS
    权利人:BASF CORP
    摘要:There is provided a single-step process for the preparation of a compound of formula I. n Compounds of formula I are useful as starting materials in the synthesis of natural products and in the manufacture of benzophenone fungicidal agents.

    专利号:US-10906880-B2
    优先权日:2016-01-26
    标题:Kind of isothiazole oxime ether-containing strobilurin derivatives and its preparation methods and application
    发明人:FAN ZHIJIN; CHEN LAI; GUO XIAOFENG; ZHU YUJIE; QIAN XIAOLIN; MA LIUYONG; ZHANG NAILOU; WANG HAIXIA; ZHANG ZHIMING; XU JINGHUA; SONG YINQI
    权利人:UNIV NANKAI
    摘要:The present invention is that provided a synthesis method of a series of isothiazole oxime ether containing strobilurin derivatives IV. The present invention relates to 3,4-dichloroisothiazolyl oxime ether strobilurin derivatives, and their chemical structural formula is as shown by IV. n n n n n n n n n n The invention discloses the structural formula of the above compound, the synthesis method and the use as an insecticide, a fungicide, an anti-plant virus agent, and an agriculturally acceptable auxiliary or synergist and a commercial insecticide. The use of a fungicide, an anti-plant virus agent and an acaricide in combination for controlling agricultural, forestry, horticultural plant pests, diseases, virus diseases and preparation methods.

    专利号:US-9968097-B2
    优先权日:2012-05-30
    标题:Composition comprising a biological control agent and a fungicide selected from inhibitors of the lipid membrane synthesis, the melanine biosynthesis, the nucleic acid synthesis or the signal transduction
    发明人:WACHENDORFF-NEUMANN ULRIKE; ANDERSCH WOLFRAM; STENZEL KLAUS; SPRINGER BERND
    权利人:BAYER CROPSCIENCE AG
    摘要:The present invention relates to a composition comprising at least one biological control agent. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts.

    专利号:US-2007232495-A1
    优先权日:2006-03-24
    标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
    发明人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.

    专利号:WO-2021074309-A1
    优先权日:2019-10-16
    标 题:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives as fungicides for combating specific phytopathogens
    发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; SEN INDIRA; BIERI STEPHANE; DIGGELMANN MARTIN
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-3,4-dihydroisoquinoline derivative of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale) when spayed on plants), as well as comparative data against three prior art compounds (e.g. pages 52 to 85; formulation examples; examples A1 to A3; table E; compounds E.01 to E.187; biological examples). Exemplary compounds are e.g.: 5-bromo-1-(8-fluoro-3-quinolyl)spiro[4H-isoquinoline-3,1'- cyclopropane] (example A1) 5-bromo-1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline (example A2) 1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline-5-carbonitrile (example A3)
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    主要参考文献


    1: Kunova A, Pizzatti C, Bonaldi M, Cortesi P. Metrafenone resistance in a population of Erysiphe necator in northern Italy. Pest Manag Sci. 2016 Feb;72(2):398-404. doi: 10.1002/ps.4060. Epub 2015 Jul 14.
    2: Li J, Li Y, Xu D, Zhang J, Wang Y, Luo C. Determination of metrafenone in vegetables by matrix solid-phase dispersion and HPLC-UV method. Food Chem. 2017 Jan 1;214:77-81. doi: 10.1016/j.foodchem.2016.07.061. Epub 2016 Jul 11. doi: 10.1016/j.foodres.2018.03.058. Epub 2018 Mar 24. doi: 10.1016/j.foodchem.2015.09.019. Epub 2015 Sep 8. doi: 10.3390/molecules19068093.
    7: Noguerol-Pato R, Sieiro-Sampedro T, González-Barreiro C, Cancho-Grande B, Simal-Gándara J. Effect on the aroma profile of Graciano and Tempranillo red wines of the application of two antifungal treatments onto vines. Molecules. 2014 Aug 13;19(8):12173-93. doi: 10.3390/molecules190812173. Erratum in: Molecules. 2014;19(11):17422-3. Sieiro-Sampredro, Thais [Corrected to Sieiro-Sampedro, Thais].

    合成参考文献


    摘要:S132 | UJIGCAPCICCS | A GC-APCI-IMS-HRMS CCS Library from Izquierdo-Sandoval et al. (2022) | DOI:10.5281/zenodo.15831151
    参考文献:10.1007/s11356-022-18933-5
    摘要:Schönenberger UT, Beck B, Dax A, Vogler B, Stamm C. Pesticide concentrations in agricultural storm drainage inlets of a small Swiss catchment. Environmental Science and Pollution Research. 2022 Feb 05;29(29):43966–83. doi: 10.1007/s11356-022-18933-5.
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