专利号:WO-2005100367-A1 优先权日:2004-04-13 标 题 :Intermediates useful in the synthesis of 3-(2-substituted vinyl) cephalosporins 发明人:KUMAR YATENDRA; PRASAD MOHAN; SINGH KAPTAN; PRASAD ASHOK; RICHHARIYA SANTOSH 权利人:RANBAXY LAB LTD; KUMAR YATENDRA; PRASAD MOHAN; SINGH KAPTAN; PRASAD ASHOK; RICHHARIYA SANTOSH 摘要:The present invention relates to crystalline intermediates useful in the synthesis of 3-(2-substituted vinyl) cephalosporins and processes for their preparation. In particular, the present invention relates to crystalline ylides of Formula I, processes for their preparation, and their use as an intermediate in thepreparation of 3-(2-substituted vinyl) cephalosporins.
专利号:US-4782146-A 优先权日:1986-07-29 标题 :Process for the synthesis of penems 发明人:BRIGHTY KATHERINE E 权利人:PFIZER 摘要:A process for the synthesis of penems from azetidinones via 1-aza-4,5-dithiabicyclo[4.2.0]oct-2-en-8-one-2-carboxylate esters.
专利号:US-6924375-B2 优先权日:2003-09-03 标题:Facile synthesis of 1,9-diacyldipyrromethanes 发明人:LINDSEY JONATHAN S; TAMARU SHUN-ICHI; YU LIANHE 权利人:UNIV NORTH CAROLINA STATE 摘要:The present invention provides a method of making a metal complex. The method comprises the steps of: (a) acylating a dipyrromethane or a 1-monoacyldipyrromethane to form a mixed reaction product comprising a 1,9-diacyidipyrromethane; (b) combining the reaction product with a compound of the formula R 2 MX 2 in the presence of a base, where R is alkyl or aryl, M is Sn, Si, Ge, or Pb (preferably Sn), and X is halo, OAc, acac, or OTf, to form a product comprising a metal complex of the formula DMR 2 in the mixed reaction product, wherein D is a 1,9-diacyldipyrromethane; and then (c) separating the metal complex from the mixed reaction product. The method may be utilized for the convenient synthesis and separation of 1,9-diacyldipyrromethanes. Metal complex intermediates useful in such methods are also described.
专利号:US-4340672-A 优先权日:1979-09-19 标 题:Enzymatic synthesis of β-lactam antibacterials 发明人:KONDO EIJI; MITSUGI TAKASHI; FUJIWARA TAMIO; MUNEYUKI RYONOSUKE 权利人:SHIONOGI & CO 摘要:Penicillins and cephalosporins can be synthesized by the action of an acylase on a penicillin or cephalosporin nucleus amine as substrate and an ester (I) of the following formula as the acyl source: (I) (wherein RCO is an acyl group in penicillin or cephalosporin side chains; X is a hydrogen atom, lower alkyl group or hydroxy-lower alkyl group; Y is a hydrogen atom or a lower alkyl group; and n is a positive integer). The novel acyl source (I) is also disclosed.
专利号:US-4369312-A 优先权日:1980-07-04 标 题:Method of producing oxo-containing azetidinone compounds 发明人:HASHIMOTO MASASHI; ARATANI MATSUHIKO; HAGIWARA DAIJIRO; SAWADA KOZO; ONAMI TETSUO 权利人:FUJISAWA PHARMACEUTICAL CO 摘要:This invention relates to a novel method of producing oxo-containing azetidinone compounds, or salts thereof, or hydrates thereof, said compounds having utility as antimicrobial agents and as intermediates for the synthesis of other azetidinone compounds having antimicrobial activity.
专利号:US-4841042-A 优先权日:1985-03-19 标 题 :Process for the preparation of carbapenem intermediates 发明人:HAEBICH DIETER; HARTWIG WOLFGANG 权利人:BAYER AG 摘要:A process for the preparation of a 4-[3-carboxy-3-diazo-2-oxopropyl]azetidin-2-one of the formula ##STR1## comprising reacting a 4-acetoxy-2-azetininone of the formula ##STR2## with a compound of the formula ##STR3## in an inert solvent, in the presence of a base and of a silylating agent, in a one-pot process. n Many of the products are new. The products are useful in the synthesis of carbapenem antibiotics.
[参考文献]: Fabrizio Carta, Et Al. Carbonic Anhydrase Inhibitors. Inhibition Of The β-Class Enzymes From The Fungal Pathogens Candida Albicans And Cryptococcus Neoformans With Branched Aliphatic/aromatic Carboxylates And Their Derivatives. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2521-6.
合成参考文献
摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2025). 摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2026). 摘要:Kwiecień, H. U., Science of Synthesis: Knowledge Updates, (2024) 3, 172.