CAS: 1863-63-4; Ammonium Benzoate

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CAS号22415-91-4 Α-D-五苯甲酸酰葡萄糖 | CAS号55-21-0 苯甲酰胺 | CAS号446-32-2 2-氨基-4-氟苯甲酸

苯甲酸置于ammonium Hydroxide体系中,用 水 用作溶剂,化学反应生成苯甲酸铵
参考文献:Synthesis,Characterization,And Thermodynamic Study Of Ammonium Benzoate C7H5O2Nh4(S)
标题:Synthesis,Characterization,And Thermodynamic Study Of Ammonium Benzoate C7H5O2Nh4(S)
摘要:Benzoic Acid And Concentrated Ammonia Were Chosen As Reactants And A Novel Compound (Ammonium Benzoate) Was Synthesized Using The Method Of Liquid Phase Reaction. Ftir,Elemental Analysis And X-Ray Powder Diffraction Technique Were Applied To Characterize The Structure And Composition Of The Compound. Low-Temperature Heat Capacities Of The Solid Compound Were Measured By A Precision Automated Adiabatic Calorimeter Over The Temperature Range From 80 To 399K. A Polynomial Equation Of The Heat Capacities Was Fitted By The Least-Squares Method. In Accordance With Hess' Law,A Thermochemical Cycle Was Designed,The Enthalpy Change Of The Reaction Of Benzoic Acid With Ammonium Acetate Was Determined As Delta H-R(M)Degrees = (15.59 +/-0.50) Kj Mol(-1),And The Standard Molar Enthalpy Of Formation Of The Compound Was Calculated As Delta H-F(M)Degrees [c7H5O2Nh4,S] =-(472.65 +/-0.62) Kj Mol(-1) By An Isoperibol Solution-Reaction Calorimeter. (C) 2010 Elsevier B.V. All Rights Reserved.
Doi:10.1016/j.Tca.2010.01.021

专利信息

专利号:US-3979396-A
优先权日:1973-12-03
标 题 :Synthesis of biotin
发明人：CONFALONE PASQUALE NICHOLAS; USKOKOVIC MILAN RADOJE; PIZZOLATO GIACOMO
权利人:HOFFMANN LA ROCHE
摘要:Synthesis of biotin from 4-carbomethoxy-2-(4,5-dihydrothiophen-3(2H)-one)-valeric acid methyl ester, and dihydrothiophene intermediates in this synthesis.

专利号:US-5321143-A
优先权日:1988-05-26
标题 :Ruthenium-catalyzed production of cyclic sulfates
发明人：SHARPLESS K BARRY; GAO YUN
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:A ruthenium catalyzed method to synthesize cyclic sulfate compounds from the corresponding cyclic sulfites, and the cyclic sulfate reaction products obtained by this method. These cyclic sulfates further react with selected nucleophiles to give various substituted products. The method is an efficient means for the synthesis of chiral building blocks from tartaric acid enantiomers in high yields using an overall two-stage, one-pot reaction procedure. The chiral compounds can be transformed by nucleophilic reactions into chiral building blocks useful for the synthesis of natural biologically active products, such as antibiotics and pheromones.

专利号:US-8476437-B2
优先权日:2008-08-27
标题:Process for preparation of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro [1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-l-(2,4,5-trifluorophenyl)butan-2-amine and new impurities in preparation thereof
发明人：KOTHARI HIMANSHU MADHUSUDAN; DAVE MAYANK GHANSHYAMBHAI; PANDEY BIPIN; SHUKLA BHAVIN SHRIPRASAD
权利人:KOTHARI HIMANSHU MADHUSUDAN; DAVE MAYANK GHANSHYAMBHAI; PANDEY BIPIN; SHUKLA BHAVIN SHRIPRASAD; CADILA HEALTHCARE LTD
摘要:The present invention relates to synthesis of β-amino acid derivatives of formula (I) and its salts of formula (Ia) by a novel process. The process comprises the reduction of a protected or unprotected prochiral β-amino acrylic acid or derivative there of, by using borane containing reducing agents at atmospheric pressure. The resulting racemic β-amino compound is resolved to a pure stereoisomer of formula (I), specifically to (2R)-4-oxo-4-[3-Ctrifluoromethyl)-5,6-dihydrol[1,2,4]triazolo[4,3-alpyrazin-7(8H)-yl]-1-(2,4,4-trifluorophenyl)butan-2-amine. In an embodiment the invention disclosed polymorphic forms of formula (I), phosphate salt of formula (I) and also a Dibenzoyl-L-tartaric acid salt of formula (I).

专利号:US-8124372-B2
优先权日:2007-06-25
标 题:Selective enzymatic amidation of C-terminal esters or acids of peptides
发明人：EGGEN IVO FRANCI; BOERIU CARMEN GABRIELA
权利人:EGGEN IVO FRANCI; BOERIU CARMEN GABRIELA; ORGANON NV
摘要:The present invention relates to a process for the amidation of C-terminal esters or acids of peptide substrates in solution-phase synthesis of peptides, comprising amidating one or more peptide substrates comprising C-terminal esters or acids using the protease subtilisin in any suitable form in the presence of an ammonium salt derived from an acid having a pKa above 0. n This process is useful in the production of protected or unprotected peptides.

专利号:US-8133999-B2
优先权日:2003-07-30
标题 :Process for preparation of 6, 7-bis(2-methoxyethoxy) quinazolin-4-one
发明人：NISHINO SHIGEYOSHI; HIROTSU KENJI; SHIMA HIDETAKA; ODA HIROYUKI; SUZUKI SHINOBU
权利人:NISHINO SHIGEYOSHI; HIROTSU KENJI; SHIMA HIDETAKA; ODA HIROYUKI; SUZUKI SHINOBU; UBE INDUSTRIES
摘要:6,7-Bis(2-methoxyethoxy)quinazolin-4-one of formula (5) useful in synthesis of an anti-cancer drug can be prepared by a reaction of ethyl 2-amino-4,5-bis(2-methoxyethoxy)benzoate of formula (4) with an orthoformic acid in the presence of an ammonium acetate:

专利号:EP-2167673-B1
优先权日:2007-06-25
标题:Process for the conversion of c-terminal peptide esters or acids to amides employing subtilisin in the presence of ammonium salts
发明人：EGGEN IVO FRANCI; BOERIU CARMEN G
权利人:ORGANON NV
摘要:The present invention relates to a process for the amidation of C-terminal esters or acids of peptide substrates in solution-phase synthesis of peptides, comprising amidating one or more peptide substrates comprising C-terminal esters or acids using the protease subtilisin in any suitable form in the presence of an ammonium salt derived from an acid having a pKa above 0. This process is useful in the production of protected or unprotected peptides.