CAS: 1745-07-9; 6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline

相似化合物

2328-12-3 43207-78-9 31756-14-6

上下游产品

CAS号110098-01-6 (1S,4R)-2-(3,4-... | CAS号3382-18-1 6,7-二甲氧基-3,4-二氢异喹啉 | CAS号50-00-0 甲醛 | CAS号120-20-7 3,4-二甲氧基苯乙胺 | CAS号648910-20-7 N-[(3-methyl-2-... | CAS号2328-12-3 6,7-二甲氧基-1,2,3,... | CAS号4230-93-7 3,4-二甲氧基-β-硝基苯乙烯 | CAS号127119-08-8 N-B°C-6,7 dimet... | CAS号111631-72-2 2-氯乙酰基-6,7-二甲氧基... | CAS号52768-23-7 四氢-6,7-异喹啉二醇 | CAS号50896-90-7 R-四氢罂粟碱 | CAS号4747-98-2 S-四氢罂粟碱 | CAS号15248-39-2 6,7-二甲氧基异喹啉 | CAS号91-01-0 二苯甲醇 | CAS号464-72-2 苯频哪醇 | CAS号3382-18-1 6,7-二甲氧基-3,4-二氢异喹啉 | CAS号102395-78-8 6,7-dimethoxy-2... | CAS号24456-59-5 ,7-二甲氧基-1,2,3,4...

📜6,7-二甲氧基异喹啉置于十六羰基六铑 一氧化碳,硫酸,水体系中,用 甲醇,乙二醇甲醚 用作溶剂,25.0~150.0 °C,5.49 Mpa 条件下,反应 72.0H,反应生成6,7-二甲氧基-1,2,3,4-四氢异喹啉
参考文献:水煤气变换条件下喹啉和异喹啉的铑催化加氢
标题:水煤气变换条件下喹啉和异喹啉的铑催化加氢
摘要:在催化量的铑羰基簇的存在下,通过一氧化碳和水可以在含氮环中选择性地氢化多种喹啉和异喹啉.这些反应为制备 1,2,3,4-四氢喹啉和 1,2,3,4-四氢异喹啉提供了一种有用的方法,它们是合成异喹啉生物碱和其他生物活性氮化合物的关键中间体.
Doi:10.1246/bcsj.62.2968

专利信息

专利号:US-3875167-A
优先权日:1972-05-26
标 题 :Synthesis of thalicarpine
发明人：KUPCHAN S MORRIS; LIEPA ANDRIS J
权利人:RESEARCH CORP
摘要:There is disclosed a novel total synthesis of thalicarpine which includes inter alia a total synthesis of hernandaline. The novel process is characterised in utilizing simple and readily available starting materials to form a diaryl ether system which is then condensed with a 3,4-dihydroisoquinolinium salt which is then converted to hernandaline. Hernandaline is reacted with a bicyclic Reissert compound to yield a compound having the thalicarpine skeleton, nascent hydrogen reduction yields Nmonodesmethyl thalicarpine which is methylated.

专利号:US-6248891-B1
优先权日:1997-05-23
标题:Synthesis of acridine derivative multidrug-resistant inhibitors
发明人：SHARP MATTHEW JUDE; MADER CATHERINE J; STRACHAN CALUM
权利人:GLAXO WELLCOME INC
摘要:Synthesis of the MDRI of formula (I) from intermediates of acridone acid of formula (II) and aminophenethyl isoquinoline of formula (III), via steps including coupling and conversion to yield the MDRI of formula (I).

专利号:US-8506927-B2
优先权日:2011-01-05
标 题 :Pegylated fluorobenzamide analogues, their synthesis and use in diagnostic imaging
发明人：MACH ROBERT H; TU ZHUDE
权利人:MACH ROBERT H; TU ZHUDE; UNIV WASHINGTON
摘要:Pegylated fluoroalkoxybenzamide compounds which selectively bind Sigma-2 receptors are disclosed. These compounds, when labeled with a positron-emitting radioisotope such as 18 F, can be used as radiotracers for medical imaging such as imaging of tumors by positron emission tomography (PET). In addition, these compounds, when labeled with 123 I, can be used as radiotracers for imaging of tumors by single photon emission computed tomography (SPECT). Methods for synthesis of these compounds are also disclosed.

专利号:US-7872138-B2
优先权日:2006-08-07
标 题 :Process for the preparation of substituted-1,2,3,4-tetrahydroisoquinoline derivatives
发明人：VILLANI FRANK J; ZHONG HUA
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to a process for the synthesis of substituted-1,2,3,4-tetrahydroisoquinoline derivatives, useful as intermediates in the synthesis of pharmaceutical agents.

专利号:US-9458111-B2
优先权日:2010-07-29
标题:Process for the synthesis of substituted urea compounds
发明人：LEARMONTH DAVID ALEXANDER; BROADBELT BRIAN; WAHNON JORGE BRUNO REIS
权利人:LEARMONTH DAVID ALEXANDER; BROADBELT BRIAN; WAHNON JORGE BRUNO REIS; BIAL—PORTELA & CA S A
摘要:A process for preparing a substitute urea of Formula (II) or Formula (I), or a pharmaceutically acceptable salt or ester thereof: n nthe process comprising the reaction of a carbamate of Formula (II′): Formula (I′):n n nwith a primary or secondary amine of the formula R1R2NH, wherein ring A, and R1, R2, R5, V, W, X, Y and Z are as defined herein.

专利号:US-2015197503-A1
优先权日:2012-07-27
标题 :Process for the synthesis of substituted urea compounds
发明人：RUSSO DOMENICO; WAHNON JORGE BRUNO REIS; MATON WILLIAM; ESZENYI TIBOR
权利人:BIAL PORTELA & Cª S A
摘要:A process for preparing a substituted urea compound of Formula II or Formula I, or a pharmaceutically acceptable salt or ester thereof, Formula II, Formula I the process comprising the reaction of an intermediate of Formula II′ or Formula 1′, Formula II′, Formula I′ with a carbamoyl halide of the formula: R1R2NC(=0)Hal, in a solvent consisting essentially of pyridine, wherein Hal represents Cl, F, I or Br, and wherein ring A, and R1, R2, R5, V, W, X, Y and Z are as defined herein.