CAS: 13991-37-2; (E)-Pent-2-Enoic Acid

相似化合物

1576-95-0 818-59-7 1576-87-0

上下游产品

quinoline malonic acid propionaldehyde 3-hydroxyvaleric acidpropionic acid Tiglic acid butanone ethyl 2-pentenoate

1,4-二氯-2-己酮置于sodium Hydroxide,溴体系中,用 1,4-二氧六环 用作溶剂,化学反应 3.0H,以65%的收率获得反式-2-戊烯酸
参考文献:Akhmedov,M.A.; Sardarov,I.K.; Akhmedov,I.M.,Journal Of Organic Chemistry Ussr (English Translation),1991,Vol. 27,# 11.1,P. 2025-2028
标题:Akhmedov,M.A.; Sardarov,I.K.; Akhmedov,I.M.,Journal Of Organic Chemistry Ussr (English Translation),1991,Vol. 27,# 11.1,P. 2025-2028

专利信息

专利号:US-9242965-B2
优先权日:2013-12-31
标题:Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
发明人：ZHENG JUNCHENG; DENG DA; LV GUANGHUA; YAN JUN; BRANDENBURG JOERG; KROEBER JUTTA; SCHOLZ ULRICH
权利人:BOEHRINGER INGELHEIM INT
摘要:The present invention is directed to an efficient process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form of formula I n nwherein R 1 and R 2 independently denote C 1-3 -alkyl groups and X − denotes an acid anion, such as the chloride, bromide, tosylate, mesylate or trifluoroacetate anion, with high quality, and a process for synthesis of EGFR tyrosine kinase inhibitors with heterocyclic quinazoline, quinoline or pyrimidopyrimidine core structure, using the acid addition salt I and activated derivatives thereof as intermediates.

专利号:US-4910330-A
优先权日:1987-09-25
标题 :Synthesis of sulfonic acids and carboxylic acid ester derivatives thereof
发明人：MCGEE DENNIS E; HALLEN TED S
权利人:UNION OIL CO
摘要:Hydroxy sulfonic acids in general and isethionic acid (2-hydroxy ethyl sulfonic acid) in particular can be prepared at 99+% purity and good yields by the selective oxidation of a precursor hydroxy mercaptan with hydrogen peroxide. The resulting product is pure enough to be used directly in the synthesis of sulfo-acrylic esters which are finding considerable use as stabilizers in producing vinylidene chloride copolymers used for FDA approved packaging films.

专利号:US-4987250-A
优先权日:1987-09-25
标 题:Synthesis of hydroxy sulfonic acids
发明人：MCGEE DENNIS E; HALLEN TED S
权利人:UNION OIL CO
摘要:Hydroxy sulfonic acids in general and isethionic acid (2-hydroxy ethyl sulfonic acid) in particular can be prepared at 99+% purity and good yields by the selective oxidation of a precursor hydroxy mercaptan with hydrogen peroxide. The resulting product is pure enough to be used directly in the synthesis of sulfo-acrylic esters which are finding considerable use as stabilizers in producing vinylidene chloride copolymers used for FDA approved packaging films.

专利号:US-5668164-A
优先权日:1996-07-12
标 题:Process for synthesis of chiral cis-and trans-3-amino-4 substituted pyrrolidine compounds
发明人：MA ZHENKUN; COOPER CURT S; FUNG ANTHONY K L; CHU DANIEL T
权利人:ABBOTT LAB
摘要:Process for preparation of chiral cis-3,4-substituted pyrrolidine compounds having the formulas: ##STR1## and chiral 3,4-trans-substituted pyrrolidine compounds having the formulas: ##STR2## with the assistance of a streochemically directing chiral oxazolidinone moiety having the formula: ##STR3## wherein P, R and R 1 are specifically defined, by sequential reaction of the compound or subsequent intermediates with an a,b-unsaturated add chloride, reaction with N-benzyl-N-(methoxymethyl)trimethyl-silylmethylamine and separating isomers by chromatography, hydrolytic removal of the oxazolidinone moiety, reaction with diphenylphosphoryl azide and triethylamine, and debenzylating; and novel intermediates of the process.

专利号:US-12163079-B2
优先权日:2019-08-12
标 题 :Synthesis of blue-emitting ZnSe1-xTex alloy nanocrystals with low full width at half-maximum
发明人：NEWMEYER BENJAMIN; IPPEN CHRISTIAN; MA RUIQING
权利人:SHOEI CHEMICAL IND CO
摘要:The invention pertains to the field of nanotechnology. The invention provides highly luminescent nanostructures, particularly highly luminescent nanostructures comprising a ZnSe 1-x Te x core and ZnS and/or ZnSe shell layers. The nanostructures comprising a ZnSe 1-x Te x core and ZnS and/or ZnSe shell layers display a low full width at half-maximum and a high quantum yield. The invention also provides methods of producing the nanostructures.

专利号:US-11697830-B2
优先权日:2015-04-15
标 题 :Iterative platform for the synthesis of alpha functionalized products
发明人：GONZALEZ RAMON; CLOMBURG JAMES M; CHEONG SEOKJUNG
权利人:GONZALEZ RAMON; CLOMBURG JAMES M; CHEONG SEOKJUNG
摘要:The use of microorganisms to make alpha-functionalized chemicals and fuels, (e.g. alpha-functionalized carboxylic acids, alcohols, hydrocarbons, amines, and their beta-, and omega-functionalized derivatives), by utilizing an iterative carbon chain elongation pathway that uses functionalized extender units. The core enzymes in the pathway include thiolase, dehydrogenase, dehydratase and reductase. Native or engineered thiolases catalyze the condensation of either unsubstituted or functionalized acyl-CoA primers with an alpha-functionalized acetyl-CoA as the extender unit to generate alpha-functionalized β-keto acyl-CoA. Dehydrogenase converts alpha-functionalized β-keto acyl-CoA to alpha-functionalized β-hydroxy acyl-CoA. Dehydratase converts alpha-functionalized β-hydroxy acyl-CoA to alpha-functionalized enoyl-CoA. Reductase converts alpha-functionalized enoyl-CoA to alpha-functionalized acyl-CoA. The platform can be operated in an iterative manner (i.e. multiple turns) by using the resulting alpha-functionalized acyl-CoA as primer and the aforementioned alpha-functionalized extender unit in subsequent turns of the cycle. Termination pathways acting on any of the four alpha-functionalized CoA thioester intermediates terminate the platform and generate various alpha-functionalized carboxylic acids, alcohols and amines with different β-reduction degree.