CAS: 116834-96-9; 3-Methyl-1H-Pyrazolo[3,4-B]Pyridine

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📜1-(2-氯吡啶-3-基)乙醇置于chromium(Vi) Oxide,一水合肼体系中,用 丙酮,正丁醇 用作溶剂,化学反应 3.25H,反应生成3-甲基-1H-吡唑并[3,4-B]吡啶
参考文献: 3-(1H-Imidazo[4,5-C]Pyridin-2-yl)-1H-Pyrazolo[3,4-B]Pyridine And Therapeutic Uses Thereof[fr] 3-(1H-Imidazo[4,5-C]Pyridin-2-yl)-1H-Pyrazolo[3,4-B]Pyridine Et Ses Utilisations Thérapeutiques
标题: 3-(1H-Imidazo[4,5-C]Pyridin-2-yl)-1H-Pyrazolo[3,4-B]Pyridine And Therapeutic Uses Thereof[fr] 3-(1H-Imidazo[4,5-C]Pyridin-2-yl)-1H-Pyrazolo[3,4-B]Pyridine Et Ses Utilisations Thérapeutiques
摘要:Azaindazole化合物用于治疗各种疾病和病理已被披露.更具体地,本发明涉及使用azaindazole化合物或其类似物,治疗由wnt途径信号激活所特征的疾病(例如,癌症,异常细胞增殖,血管生成,纤维化疾病,骨骼或软骨疾病和骨关节炎),调节由wnt途径信号介导的细胞事件,以及由于wnt途径和/或一个或多个wnt信号组分的突变或失调而导致的遗传疾病和神经病理条件/障碍/疾病.还提供了治疗与wnt相关疾病状态的方法.

专利信息

专利号:US-10000487-B2
优先权日:2015-11-20
标 题 :Heterocyclic compounds that inhibit the kinase activity of Mnk useful for treating various cancers
发明人：SPRENGELER PAUL A; REICH SEIGFRIED H; WEBBER STEPHEN E; ERNST JUSTIN T
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula IA or Formula IB, as well as stereoisomers, tautomers or pharmaceutically acceptable salts thereof. n nFor Formula IA and Formula IB compounds A 1 , A 2 , A 3 , A 4 , W 1 , W 2 , Y, X, R 1 , R 2 , R 3 , R 4a , R 4b , R 5a , R 5b , R 6 , R 7 , R 8 , R 9 , R 9a , R 9b , R 10 and subscript n are as defined in the specification. The inventive Formula IA and Formula IB compounds are inhibitors of Mnk and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

专利号:US-10995078-B2
优先权日:2013-03-13
标 题:Compounds and compositions for inhibition of FASN
发明人：BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J
权利人:FORMA THERAPEUTICS INC
摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:US-2024409557-A1
优先权日:2023-05-09
标 题 :5,6-fused and 6,6-fused bicyclic alcohols and ethers and compositions for use as 15-prostaglandin dehydrogenase modulators
发明人：GREENMAN KEVIN LLOYD; PICKRELL ALEXANDER J; LI KEXUE; AMEGADZIE ALBERT K; WANG HUI-LING; WEIRES NICHOLAS ANTHONY; ALLEN JOHN G; BOURBEAU MATTHEW P
权利人:AMGEN INC
摘要:The present disclosure provides novel 15-hydroxy-prostaglandin dehydrogenase inhibitors, pharmaceutical compositions comprising such compounds, and methods of using such compounds and compositions in treating 15-hydroxy-prostaglandin dehydrogenase-mediated disease. Also provided are methods of making such compounds and intermediates thereof. The compounds have a general Formula (A).Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (A).

专利号:US-7541367-B2
优先权日:2005-05-31
标 题 :3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders
发明人：CHIU GEORGE; CONNOLLY PETER J; EMANUEL STUART; HUANG SHENLIN; LI SHENGJIAN; LIN RONGHUI; LU YANHUA; MIDDLETON STEVEN A
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to novel 3-benzoimidazolyl-pyrazolopyridine compounds of formula (I): n nand pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of serine-threonine protein kinases and tyrosine protein kinases and interactions thereof.