CAS: 113-78-0; Demoxytocin
该化合物是天然荷尔蒙催产素的合成类似物,其主要特征是其结构改变,以提高其稳定性和生物活动;脱氧催产素对催产素的生理影响相似,包括社会联系,生殖功能和哺乳的作用;该化合物经常用于研究和临床环境,以研究其对行为和生理的影响;从化学角度讲,脱氧酚是一种浸泡物,由一系列氨基酸组成,有助于其生物功能;其稳定性允许身体与自然对应物相比长期活动;此外,脱氧催产素在包括产科和妇科在内的各种治疗领域可能具有应用性,因为它能够诱发子宫萎缩;然而,与任何合成激素一样,认真考虑剂量和潜在副作用在其应用中至关重要.
- 英文名称Demoxytocin
- 中文名称去氨缩宫素
- IUPAC名称(S)-1-((4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-((S)-sec-butyl)-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)-N-((S)-1-((2-amino-2-oxoethyl)amino)-4-methyl-1-oxopentan-2-yl)pyrrolidine-2-carboxamide
- 其它别名demoxyt°Cin; Demossit°Cina [DCIT]; deaminooxyt°Cin; 1-(3-Mercaptopropionic acid)oxyt°Cin; Deaminoxyt°Cin; 1-[4-(2-amino-2-keto-ethyl)-7-(3-amino-3-keto-propyl)-13-(4-hydroxybenzyl)-3,6,9,12,15-pentaketo-10-sec-butyl-18,19-dithia-2,5,8,11,14-pentazacycloicosane-1-carbonyl]-N-[1-[(2-amino-2-keto-ethyl)carbamoyl]-3-methyl-butyl]pyrrolidine-2-carboxamide; N-[1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]-1-[4-(2-amino-2-oxoethyl)-7-(3-amino-3-oxopropyl)-10-butan-2-yl-13-[(4-hydroxyphenyl)methyl]-3,6,9,12,15-pentaoxo-18,19-dithia-2,5,8,11,14-pentazacycloicosane-1-carbonyl]pyrrolidine-2-carboxamide; N-[1-[(2-azanyl-2-oxo-ethyl)amino]-4-methyl-1-oxo-pentan-2-yl]-1-[[4-(2-azanyl-2-oxo-ethyl)-7-(3-azanyl-3-oxo-propyl)-10-butan-2-yl-13-[(4-hydroxyphenyl)methyl]-3,6,9,12,15-pentaoxo-18,19-dithia-2,5,8,11,14-pentazacycloicos-1-yl]carbonyl]pyrrolidine-2-carboxamide
- CAS编号113-78-0
- MFCD编号:MFCD00867797
- EINECS号:204-034-9
- FDA UNII编号:2N9HM3X95F
- 分子式:C43H65N11O12S2分子量:992.17
- 产品CID: 169582
- 产品分类原料药 → 激素及调节内分泌功能类药 → 垂体激素类药
物理性质
- 沸点1518.8 °C at 760mmHg
- 闪点872.3 °C
- 密度1.263g/cm3
- pKa:9.90±0.15(预测)
- PSA:424.11
- LogP:1.9188
- 折射率1.551
- 蒸汽压0mmHg at 25°C
- 外观形态固体-粉末
- 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
- 产品应用该化合物是一种催产催产药物,用于诱发劳动,促进哺乳,预防和治疗产后(产后)胸炎(乳腺炎);脱氧催产物是催产性类似催产酶的合成类似物,具有类似活动,但更强大,半衰期更长. 与通过静脉注射注射提供的催产毒剂不同,脱氧素作为泡泡片配方施用.
MSDS等安全信息
上下游产品
N-(fluoren-9-ylmethoxycarbonyl)glycine Fm°C-Leu-OH Fm°C-Pro-OH Fm°C-Ile-OH合成工艺路线路线简述
海关参考信息
- 2902600000-乙苯
2912110000-甲醛
2912120000-乙醛
2921211000-乙二胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-0054773-A1
优先权日:1999-03-12
标题:Dopamine agonists in combination with nitric oxide donors, compositions and methods of use
发明人：GARVEY DAVID S
权利人:NITROMED INC; GARVEY DAVID S
摘要:The present invention is directed to novel compositions comprising at least one dopamine agonist in combination with at least one nitric oxide donor (i.e. compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or are substrates for nitric oxide synthase). The novel compositions may optionally comprise at least one therapeutic agent, such as, a vasoactive agent, an antimetic agent, and mixtures thereof. The dopamine agonist is preferably apomorphine. The present invention is also directed to methods for treating and/or preventing sexual dysfunctions and/or enhancing sexual responses in patients. In other embodiments, the present invention is directed to methods treating or preventing neurodegenerative diseases, mitochondrial diseases, spinal cord injury, central or psychostimulant addiction, senile dementia, circulatory disorders, cardiovascular disorders, hyperprolactinaemia or myopia. The compounds and/or compositions of the present invention can also be provided in the form of a pharmaceutical kit.
专利号:US-3679655-A
优先权日:1968-06-28
标 题:N,n-disubstituted aminoethylcarbamyl protecting groups for cysteine
发明人：JAGER GEORG; GEIGER ROLF
权利人:HOECHST AG
摘要:A METHOD OF PROTECTING THE SULFUR ATOM OF CYSTEINE N PEPTIDE SYNTHESIS BY REACTION WITH B-(N,N-DISUBSTITUTED)AMINOETHYL ISOCYANATE IN WHICH ONE SUBSTITUENT IS METHYL OR EHTYL AND THE OTHER IS BENZYLOXYCARBONYL, T-BUTYLOXYCARBONYL, OR ADAMANTYLOXYCARBONYL. FOR REMOVAL OF THE PROTECTIVE GROUP, THE PEPTIDE IS TREATED WITH A STRONG ACID TO FORM THE ACID SALT OF THE CORRESPONDING MONOSUBSTITUTED N-ETHYL OR N-METHYL AMINO COMPOUND AND THEN MADE ALKALINE TO LIBERATE THE AMINE. THE PROTECTIVE GROUP CLEAVES INTRAMOLECULARLY WITH FORMATION OF A METHYL OR ETHYL-SUBSTITUTED IMIDAZOLONE AND THE PEPTIDE IN WHICH THE CYSTEINE SULFUR ATOM IS PRESENT AS SULFHYDRYL.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Pliska V, Jutz G. Kinetics of oxytocin and deaminooxytocin displacement from the OXTR-receptor compartment in rat uterus ex vivo. Biochem Pharmacol. 2018 Feb;148:278-287. doi: 10.1016/j.bcp.2018.01.006. Epub 2018 Jan 5. Erratum in: Philos Trans R Soc Lond Biol 1990 Jun 30;328(1251):239.
合成参考文献
摘要:Chen L, Bauerová H, Slaninová J, Barany G. Syntheses and biological activities of parallel and antiparallel homo and hetero bis-cystine dimers of oxytocin and deamino-oxytocin. Pept Res. 1996 May;9(3):114–21.
参考文献:10.1126/science.3008332
摘要:Wood SP, Tickle IJ, Treharne AM, Pitts JE, Mascarenhas Y, Li JY, Husain J, Cooper S, Blundell TL, Hruby VJ, Buku A, Fischman AJ, Wyssbrod HR. Crystal Structure Analysis of Deamino-Oxytocin: Conformational Flexibility and Receptor Binding. Science. 1986 May 02;232(4750):633–6. doi: 10.1126/science.3008332.
📝 需求与反馈
尽可能描述清楚需求与问题信息
