CAS: 10226-54-7; Lomifylline
该化合物是一种纯衍生物,其结构复杂,包括纯环系统和各种替代物,其特征为净化环1和3位置的两个甲基组,有助于其疏水特性;7位置上存在5-oxexyl侧链,可加强其分子多样性,并可能影响其生物活动;作为清素类比,它可能与生物系统相互作用,可能影响核酸新陈代谢,或成为生物化学途径的前体;该化合物有可能在有机溶剂中表现出溶性,因其水中的缺水性有限;其潜在应用范围包括药物,生物化学和分子生物学,特别是在有关核糖酸的研究中或作为了解纯代谢的研究工具.然而,具体的生物活动和毒性剖面需要通过实验研究进一步调查.
- 英文名称Lomifylline
- 中文名称洛米茶碱
- IUPAC名称1,3-dimethyl-7-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione
- 其它别名Theophylline,7-(5-oxohexyl)- (7CI,8CI); 1,3-Dimethyl-7-(5-oxohexyl)xanthine; 7-(5-Oxohexyl)-1,3-dimethylxanthine; Cervilane; Lomifylline
- CAS编号10226-54-7
- MFCD编号:MFCD00867151
- EINECS号:233-547-0
- FDA UNII编号:NA91GV8GDJ
- 分子式:C13H18N4O3分子量:278.31
- 产品CID: 50328
- 产品分类有机原料→分子砌块→芳杂环类化合物→咪唑类化合物
相似化合物
1028-33-7 6493-06-7 23146-06-7物理性质
- 熔点75-77 °C
- 沸点525.3±56.0 °C at 760 mmHg
- 闪点271.5±31.8 °C
- 密度1.3±0.1 g/cm3
- pKa:0.56±0.70(预测)
- PSA:78.89
- LogP:0.193
- 折射率1.621
- 蒸汽压0.0±1.4 mmHg at 25°C
- 溶解性Chloroform (Slightly), Methanol (Slightly)
- 外观形态白色至类白色固体
- 储存条件2-8°C
- 产品应用洛米茶碱(10226-54-7)的用途:该药是周围血管扩张药.和小剂量的双氢麦角汀配方制成的复方制剂,为Cervilane,作为抗脑衰老药使用,用于因脑血管疾病,脑衰老引起的精神行为紊乱和脑外伤综合症的治疗.
- 性质描述洛米茶碱(10226-54-7)的性状:从异丙醇得白色结晶,熔点75～76°C.
MSDS等安全信息
欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
CAS号109-49-9 烯丙基丙酮 | CAS号5745-75-5 2-Methyl-1,3-di... | CAS号71280-22-3 4-(2-methyl-1,3... | CAS号53547-04-9 7-(5-hydroxyhex...合成工艺路线路线简述
📜Toluene-4-Sulfonic Acid 4-(2-Methyl-[1,3]Dioxolan-2-yl)-Butyl Ester置于盐酸,甲醇,Potassium Carbonate体系中,化学反应 1.0H,反应生成洛米茶碱
参考文献:Potentiation Of Cadpr-Induced Ca2+-Release By Methylxanthine Analogues
标题:Potentiation Of Cadpr-Induced Ca2+-Release By Methylxanthine Analogues
摘要:Caffeine And Other Methylxanthines Are Known To Induce Ca2+-Release From Intracellular Stores Via The Ryanodine Receptor. In The Present Work,A Range Of Caffeine Analogues,In Which Methyl Groups At The 1 And 7 Positions Were Replaced With Alkyl Chains Containing Different Functional Groups (Oxo,Hydroxyl,Propargyl,Ester,And Acids),Were Synthesized. These Compounds Were Then Screened For Their Ability To Potentiate Ca2+-Release Induced By Cadpr (An Endogenous Modulator Of Ryanodine Receptors) In Sea Urchin Egg Homogenates. Two Of The Synthesized Methylxanthines,1,3-Dimethyl-7-(7-Hydroxyoctyl)Xanthine (37) And 3-Methyl-7-(7-Oxooctyl)-1-Propargylxanthine (66),Were Shown To Be More Potent Than Caffeine In Potentiating Cadpr-Induced Ca2+-Release,While 1,3-Dimethyl-7-(5-Ethylcarboxypentyl)Xanthine (14) Was Shown To Be More Efficacious. The Development Of New Methylxanthine Analogues May Lead To A Better Understanding Of Ryanodine Receptor Function And Could Possibly Provide Novel Therapeutic Agents.
Doi:10.1021/jm980469T
专利信息
专利号:RU-2051918-C1
优先权日:1985-07-19
标 题 :Method of synthesis of tertiary hydroxyalkylxanthines
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Le Poncin-Lafitte M, Grosdemouge C, Billon CR, Duterte D, Pontrat P, Lespinasse P, Rapin JR. Short-term memory and cerebral ischemia: pharmacological application. Eur Neurol. 1981;20(3):265-9.
合成参考文献
参考文献:10.1021/jm980469t
摘要:Cavallaro RA, Filocamo L, Galuppi A, Galione A, Brufani M, Genazzani AA. Potentiation of cADPR-induced Ca(2+)-release by methylxanthine analogues. J Med Chem. 1999 Jul 15;42(14):2527–34. doi: 10.1021/jm980469t.
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