CAS: 897732-93-3; Isopropyl 4-((5-Methoxy-6-((2-Methyl-6-(Methylsulfonyl)Pyridin-3-yl)Amino)Pyrimidin-4-yl)Oxy)Piperidine-1-Carboxylate

结构式图片

物理性质

MSDS等安全信息

上下游产品

(6-Chloro-5-Methoxy-Pyrimidin-4-yl)-(6-Methanesulfonyl-2-Methyl-Pyridin-3-yl)-Amine 1224097-06-6
4-(6-Chloro-5-Methoxy-Pyrimidin-4-Yloxy)-Piperidine-1-Carboxylic Acid Isopropyl Ester 897732-25-1

合成工艺路线路线简述

    📜(6-Chloro-5-Methoxy-Pyrimidin-4-yl)-(6-Methanesulfonyl-2-Methyl-Pyridin-3-yl)-Amine,4-羟基哌啶-1-甲酸异丙酯置于4-羟基哌啶-1-甲酸异丙酯体系中,化学反应生成 4-[[6-[(6-甲基磺酰基-2-甲基吡啶-3-基)氨基]-5-甲氧基嘧啶-4-基]氧基]哌啶-1-羧酸异丙酯
    参考文献:Process For The Preparation Of Tri-Substituted Pyridine And Tri-Substituted Pyrimidine Derivatives Useful As Gdir Agonists
    标题:Process For The Preparation Of Tri-Substituted Pyridine And Tri-Substituted Pyrimidine Derivatives Useful As Gdir Agonists
    摘要:本发明涉及一种制备三取代吡啶和三取代嘧啶衍生物的新型方法,其作为葡萄糖依赖性胰岛素促进受体激动剂,用于治疗代谢相关疾病及其并发症,例如糖尿病和肥胖症.

    海关参考信息

    其他信息查阅

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    实用工具

    ⚠️全国化工行业净网倡议书
    📋制造商识别码
    📖 海关编码查询
    📝MSDS生成器

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Buzard DJ, Kim SH, Lehmann J, Han S, Calderon I, Wong A, Kawasaki A, Narayanan S, Bhat R, Gharbaoui T, Lopez L, Yue D, Whelan K, Al-Shamma H, Unett DJ, Shu HH, Tung SF, Chang S, Chuang CF, Morgan M, Sadeque A, Chu ZL, Leonard JN, Jones RM. Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4332-5. doi: 10.1016/j.bmcl.2014.06.071. Epub 2014 Jul 3. doi: 10.1016/j.bmcl.2011.12.092. Epub 2011 Dec 30. doi: 10.1517/13543770903153878. Review.

    合成参考文献


    摘要:S55 | ZINC15PHARMA | Pharmaceuticals from ZINC15 | DOI:10.5281/zenodo.3247749
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知