CAS: 83462-55-9; (2R)-2-Amino-6-[4-[(2S)-2-Amino-2-Carboxyethyl]-3-[(3S)-3-Amino-3-Carboxypropyl]-5-Hydroxypyridin-1-Ium-1-Yl]Hexanoate

该化合物是一种主要在骨骼和骨浆中发现的丙烯酸衍生物和交叉连接的碳酸酯标记,是科洛林降解的产物,经常被用作临床环境中骨吸附的生化标记;DPD的特点是它有能力在科洛林纤维之间形成稳定的交叉联系,有助于连接组织的结构完整性和机械强度;该物质通常在尿液中测量,提供对骨头代谢和循环的洞察;DPD的升高水平可以表明骨吸附增加,这可能与骨质疏松或其他代谢骨病等条件相关;DPD含有一种环,并被归类为一种血循环化合物;它的分析通常涉及高性能液色谱学或质谱学等技术.

英文名称(2R)-2-Amino-6-[4-[(2S)-2-Amino-2-Carboxyethyl]-3-[(3S)-3-Amino-3-Carboxypropyl]-5-Hydroxypyridin-1-Ium-1-Yl]Hexanoate
中文名称D-焦谷氨酸
其它别名DEOXYPYRIDINOLINE; 4-[(2S)-2-Amino-2-carboxyethyl]-1-[(5S)-5-amino-5-carboxypentyl]-3-[(3S)-3-amino-3-carboxypropyl]-5-hydroxypyridinium Inner Salt; Lysylpyridinoline; 1-[(5S)-5-Amino-5-carboxylatopentyl]-3-[(3S)-3-amino-3-carboxypropyl]-4-[(2S)-2-amino-2-carboxyethyl]-5-hydroxypyridinium; 4-[(2S)-2-Amino-2-carboxyethyl]-1-[(5S)-5-amino-5-carboxylatopentyl]-3-[(3S)-3-amino-3-carboxypropyl]-5-hydroxypyridinium; D-Pyr
CAS编号83462-55-9
MFCD编号:MFCD01074893
FDA UNII编号:GXI9WV7IP9
分子式:C18H28N4O7分子量:412.44
产品CID: 1823304
产品分类生物化工 → 常见氨基酸及蛋白质类

相似结构搜索
InChIKey: ZAHDXEIQWWLQQL-IHRRRGAJSA-N
1S/C18H28N4O7/c19-12(16(24)25)3-1-2-6-22-8-10(4-5-13(20)17(26)27)11(15(23)9-22)7-14(21)18(28)29/h8-9,12-14H,1-7,19-21H2,(H3-,23,24,25,26,27,28,29)/t12-,13-,14-/m0/s1
计算化学: 氢键受体数10.0氢键供体数6.0可旋转键数12.0

MSDS等安全信息

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海关参考信息

2905121000-正丙醇
2905130000-正丁醇
2912110000-甲醛
2912120000-乙醛
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专利信息

专利号:US-5723619-A
优先权日:1997-01-13
标题 :Method for the synthesis of deoxypyridinoline
发明人：HATCH ROBERT P
权利人:BAYER AG
摘要:Disclosed is a method for the chemical synthesis of deoxypyridinoline (DPD). The synthesis involves the preparation of a protected 3-hydroxypyridinium starting with a NÎ±-protected lysine and a 5,6-epoxy-2-N-protected-O-protected-(2S)-2-aminohexanoate with subsequent deprotection to provide the desired DPD.

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合成参考文献

参考文献:10.1515/jpem.1998.11.3.471
摘要:Fujisawa Y, Yamashita K, Nakamura Y, Kida K. Increased urinary excretion of pyridinoline and deoxypyridinoline in a girl with congenital contractural arachnodactyly. J Pediatr Endocrinol Metab. 1998;11(3):471–4. doi: 10.1515/jpem.1998.11.3.471.
参考文献:10.1210/jc.81.10.3589|10.1210/jcem.81.10.8855806
摘要:Spagnoli A, Branca F, Spadoni GL, Cianfarani S, Pasquino AM, Argirò G, Vitale S, Robins SP, Boscherini B. Urinary pyridinium collagen cross-links predict growth performance in children with idiopathic short stature and with growth hormone (GH) deficiency treated with GH. Skeletal metabolism during GH treatment. The Journal of Clinical Endocrinology & Metabolism. 1996 Oct;81(10):3589–93. doi: 10.1210/jcem.81.10.8855806.
参考文献:10.1016/s0022-5347(01)65484-3|10.1097/00005392-199611000-00040
摘要:Takeuchi S, Arai K, Saitoh H, Yoshida K, Miura M. Urinary Pyridinoline and Deoxypyridinoline as Potential Markers of Bone Metastasis in Patients with Prostate Cancer. The Journal of Urology. 1996 Nov;():1691–5. doi: 10.1097/00005392-199611000-00040.
参考文献:10.1159/000117276
摘要:Ohishi T, Kushida K, Takahashi M, Kawana K, Inoue T, Yagi K. Analysis of urinary pyridinoline and deoxypyridinoline in patients undergoing long-term anticonvulsant drug therapy. Eur Neurol. 1996;36(5):300–2. doi: 10.1159/000117276.
参考文献:10.1016/0009-8981(96)06334-6
摘要:Nawawi H, Samson D, Apperley J, Girgis S. Biochemical bone markers in patients with multiple myeloma. Clin Chim Acta. 1996 Sep 30;253(1-2):61–77. doi: 10.1016/0009-8981(96)06334-6.