CAS: 7288-28-0; 5-Methyl-2,4-Bis((Trimethylsilyl)Oxy)Pyrimidine

上下游产品

Hexamethyldisiloxane 2,4-dihydroxy-5-methylpyrimidine 1,1,1,3,3,3-hexamethyl-disilazane N,N-bis(trimethylsilyl)acetamide2',3',5'-tri-O-benzoyluridine 2',3',5'-Tri-O-benzoyl-5-methyluridine 5-methyl-2-furanone levulinic acid methyl ester

📜三甲基氯硅烷,胸腺嘧啶置于六甲基二硅氮烷体系中,用 1,2-二氯乙烷 作为反应溶剂,化学反应 1.0H,以84%的收率获得产物o,O-二(三甲基甲硅烷基)胸苷
参考文献:通过结晶态核酸碱基配对的金属配合物分子组装
标题:通过结晶态核酸碱基配对的金属配合物分子组装
摘要:发现由掺入腺嘌呤(a)或胸腺嘧啶(t)碱基的钴(II)三联吡啶配合物以结晶状态形成的分子组装体的性质受存在的碱基控制.钴(II)配合物[co(a-C6-Terpy)2](bf4)2(1)和[co(t-C6-Terpy)2](bf4)2(2)的单晶具有针状和分别阻止习惯.随后将1和2在meoh中混合,得到[co(a-C6-Terpy)1.5(t-C6-Terpy)0.5](bf4)2(3)的分离,为板状晶体.1中存在一个包含1-D链的3-D网络结构,而2则采用了由梯型组件构造的2-D堆叠结构.对于3,反应生成由[co(a-C6-Terpy)2](bf4)2和[co(a-C6-Terpy)(t-C6-Terpy)](bf4)2单元组成的"二聚环"通过a和t之间的碱基配对.值得注意的是,3显示[co(a-C6-Terpy)(t-C6-Terpy)](bf4)2的杂钴(II)配合物的第一晶体结构.这些
DOI:10.1002/chem.201700593

专利信息

专利号:US-8912319-B2
优先权日:2010-07-15
标 题 :Synthesis of 2′-deoxy-2′-[18F]fluoro-5-methyl-1-B-D-arabinofuranosyluracil (18F-FMAU)
发明人：LI ZIBO; CAI HANCHENG; CONTI PETER S
权利人:LI ZIBO; CAI HANCHENG; CONTI PETER S; UNIV SOUTHERN CALIFORNIA
摘要:The present invention relates to methods of synthesizing 18 F-FMAU. In particular, 18 F-FMAU is synthesized using one-pot reaction conditions in the presence of Friedel-Crafts catalysts. The one-pot reaction conditions are incorporated into a fully automated cGMP-compliant radiosynthesis module, which results in a reduction in synthesis time and simplifies reaction conditions. The one-pot reaction conditions are also suitable for the production of 5-substituted thymidine or cytidine analogs. The products from the one-pot reaction (e.g. the labeled thymidine or cytidine analogs) can be used as probes for imaging tumor proliferative activity. More specifically, these [ 18 F]-labeled thymidine or cytidine analogs can be used as a PET tracer for certain medical conditions, including, but not limited to, cancer disease, autoimmunity inflammation, and bone marrow transplant.

专利号:US-4914233-A
优先权日:1988-03-01
标题:Synthesis of beta-thymidine
发明人：FRESKOS JOHN N; SENARATNE K PUSHPANANDA A
权利人:ETHYL CORP
摘要:A process is provided in which a mixture of alpha- and beta-anomers is converted selectively to the desired beta-thymidine. The process involves the following steps: (a) converting a mixture of alpha- and beta-anomers of tetra-O-acylribofuranose to tri-O-acyl-β-ribothymidine; (b) converting tri-O-acyl-β-ribothymidine to β-ribothymidine; (c) converting β-ribothymidine to 2,2'-anhydro-β-thymidine; (d) converting 2,2'-anhydro-β-thymidine to 2'-halo-2'-deoxy-5-methyluridine; and (e) converting 2'-halo-2'-deoxy-5-methyluridine to beta-thymidine. The mixture of alpha- and beta-anomers of tetra-O-acylribofuranose may be produced by any suitable procedure such as by converting lower alkyl ribofuranoside to the tetra-O-acylribofuranose mixture. The lower alkyl ribofuranosides may in turn be produced by various methods. However, a desirable way of effecting this conversion involves use of D-ribose as the starting material which is converted to the lower alkyl ribofuranoside.

专利号:US-2023416293-A1
优先权日:2020-11-23
标 题:Synthesis of [18f]-labeled thymidine analogues
发明人：CHEN KAI; CONTI PETER S
权利人:UNIV SOUTHERN CALIFORNIA
摘要:Thymidine analogues, 5-substituted 2′-deoxy-2′-[18F]fluoro-arabinofuranosyluracil derivatives, are promising positron emission tomography (PET) tracers being evaluated for noninvasively imaging cancer cell proliferation and/or reporter gene expression. We report the radiosynthesis of 2′-deoxy-2′-[18F]fluoro-5-methyl-1-β-d-arabinofuranosyluracil ([18F]FMAU) and other 2′-deoxy-2′-[18F]fluoro-5-substituted-1-β-d-arabinofuranosyluracil analogues using 1,4-dioxane to replace the currently used 1,2-dichloroethane. Compared to 1,2-dichloroethane, 1,4-dioxane is analyzed as a better solvent in terms of radiosynthetic yield and toxicity concern. The use of a less toxic solvent allows for the translation of the improved approach to clinical production. The new radiolabeling method can be applied to an extensive range of uses for 18F-labeling of other nucleoside analogues.

专利号:US-4987224-A
优先权日:1988-08-02
标 题 :Method of preparation of 2',3'-dideoxynucleosides
发明人：CHU CHUNG K
权利人:UNIV GEORGIA RES FOUND
摘要:A general method of synthesis of 2',3'-dideoxynucleosides which is efficient, inexpensive and based on a readily available starting material, D-mannitol.

专利号:SU-1643553-A1
优先权日:1989-05-23
标题:1, 5-di-o-benzoyl-3-fluoro-2, 3-dideoxy-d- ribofuranose as semiproduct in stereospecific synthesis of 3- fluoro-2, 3- dideoxytimidine

专利号:US-2012053337-A1
优先权日:2010-07-15
标 题 :SYNTHESIS OF 2'-Deoxy-2'-[18F]FLUORO-5-METHYL-1-B-D-ARABINOFURANOSYLURACIL (18F-FMAU)